An Apology .
Andre Willers.
24 Mar 2010
Synopsis:
I apologise unreservedly for the accellarated changes I have unleashed .
My only excuses are beauty , ignorance and stupidity .
Discussion :
1.Beauty :
The expression from Appendix B says it all . It combines 3 Billion years of evolution with Eulers Constant and quantized signals .
General Genetic Formulation : (from Appendix B)
nAminoAcids + nStops + nStarts = 1/3 * ( (nDNA-bases) ^ (nBasesPerCodon) )
where the prefix n denotes "number of"
Beautiful !
( I was on an endorphin high for 3 days , and still get a glow when I contemplate it.)
2.Ignorance .
This beauty blinded me to my ignorance of the state of the art in work like Jason Chin's at Cambridge . See Appendix A
3.Stupidity :
I should have realized that meta-controls in the genetic code (phene-systems) already made some provision for multiple bases .
The Big Mistake :
Publishing the General Genetic Formulation .
General Genetic Formulation :
nAminoAcids + nStops + nStarts = 1/3 * ( (nDNA-bases) ^ (nBasesPerCodon) )
where the prefix n denotes "number of"
Beautiful !
2/3 of my previous posts were deliberately designed to be slightly ahead of the wave-front of human knowledge , with about 1/3 designed for post-human AI's .
None of them had immediately verifiable feedbacks . The idea was that I would be safely dead when they found out what I actually said , except for some individuals who would mine the insights and take them for their own .
This General Statement is an algorithm to create Stable Neo-Genes . Not just genetic engineering . But Stable Genetic Engineering . Immediately verifiable in expressed genomes .
Oh Well .
I blew it .
What will happen :
See a system like ."Adam and Eve" at Aberystwyth University , Scotland . Dr Amanda Clare . Automated hypothesis formulation and testing . www.computescotland.com/2260.php
Using the General Formulation Algorithm , this system can zero in on stable expressions of any desired genomic code within a week or two . Literally .
Even Lab-on-a-chip can do it within a few months .
This is happening as we speak .
When I realized my mistake (16/3/2010) , I immediately tried to remove the post . Unfortunately , it had already been copied to some genetic engineering websites .
The cat was well and truly out of the bag .
But I still thought that ducking my head under the sand by cutting off all communication would help . Please forgive me for this .
Unfortunately , not only humans would examine my previous posts , but also enhanced humans.
From Appendix A :
See "Pandora bacteria acts as one organism" , NewScientist 27 Feb 2010 , p11.
Electron-conducting protein nanowires link oxygen-poor sub-mud sulfur eating bacteria on the seafloor in an interactive network suggestive of a neural net .
The manufacture of such a protein nanowire would almost certainly require 4-Base Codon cell machinery . Hence the the existence of parallel meta-controls .
These extra-connections can easily be inserted into existing human brains using the above systems , especially about 2-3 years before puberty or in babies .
The capabilities of these systems are equal or greater than my own at present . I cannot predict what will happen , except that it will be very interesting in the Chinese sense .
See posts on AI systems.
Singularity :
I had hoped for a fairly smooth ascent into the singularity , but this is now a pipe dream . There will be fast lurch into human and AI capability , as there is now an arms-race in this type of genome design .
I had hoped to avoid this till a later , more mature stage .
Oh well .
It was the beauty , your honor . The beauty .
Andre
xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Appendix A
Sent 16/3/2010
Hi ,
See ""Rewriting life in four-letter words" , NewScientist 20 Feb 2010 p14.
I just read it (16 Mar 2010) , as I get New Scientist in a haphazard fashion via the library .
See para 2 of original post below
"2.Make 4-Base Codon Cell-Machinery .
A real remake . Not within human capability at the moment ."
I was wrong .
It has already been done by Jason Chin and colleagues at the University of Cambridge . They successfully redesigned some ribosomes and transfer RNA(tRNA) to manufacture a novel amino acid (a novo-calmodulin protein) , expressed via E.Coli .
Important note:
This worked so easily because it worked parallel to the three-Base expression without noticeable inerference .
This hints that the meta-controls (see Phene-system posts) already has provisions for 4-Base cell-machinery .
Hints:
1.See "Pandora bacteria acts as one organism" , NewScientist 27 Feb 2010 , p11.
Electron-conducting protein nanowires link oxygen-poor sub-mud sulfur eating bacteria on the seafloor in an interactive network suggestive of a neural net .
The manufacture of such a protein nanowire would almost certainly require 4-Base Codon cell machinery . Hence the the existence of parallel meta-controls .
Room-temperature organic superconductors seem to be a distinct possibility .
2.Many old-age and degenerative diseases seems remiscent of 4-Base Codon cell machinery activating over time .
But what do I know .
It is your poblem now .
I hope your molecular shamans are better than your climatologist shamans .
Hugga-Bugga!
Andre .
xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Appendix B
-----Original Message-----
Sent: 22 February 2010 08:07 PM
Subject: The Beauty of the Genetic Code .
The Beauty of the Genetic Code .
Andre Willers
22 Feb 2010
Synopsis:
The present TerraIII genetic code is elegantly optimized to give the most robustness possible per unit of information .
Discussion :
You have to be familiar with the concepts in:
1. http://andreswhy.blogspot.com "NewTools:Reserves" and Beth(n) orders of Randomness .
2.NewScientist of 23 Jan 2010 p34 "Another kind of evolution"
Brief recap of Reserves argument :
We take any identifiable entity , slice and dice it with an order of randomness like that of a coin (ie Beth(0) ) . We then calculate a minimum reserve (which is equivalent to the least errors of all possible Beth(0) paths per benefit . )
This works out at 1/3 on the average over Aleph(0) infinities .
The Beauty of the Genetic Code :
Four Base pairs (A,U,C,G) in triplet codons give a possible 4*4*4 = 64 codons .
But together , they code only for 20 amino acids , plus a Stop and a Semi-Start .
This gives
20/64 = 31.22% for 20 amino acids
21/64 = 32.81% for 20 amino acids + Stop
21.3333…/64 = 33.3333… for 20 amino acids + Stop + Semi-Start
22/64 = 34.375 %
Stop = (UGG) , (UGA) , (UAG) ,
Start = (AUG) , but this also codes for methionine . Hence the decimal notation . The system cannot come closer to 1/3 because of quantal considerations . Try it and see .
This also is the portal for the Epigenetic System ( note use of methiolization) .
Beautiful !!
Consider the ways of Gaia .
Linear and Sideways evolution .
Linear :
The standard , gene and chromosome based inheritance
Equivalent to Beth(1+x) in our notation .
1>= x >=0
Sideways :
Genetic material exchanged without going through all that genotype-phenotype procedures .
Equivalent to Beth(1-x) in our notation .
1>= x >=0
Note that the system could not possibly get as close to the optimum reserve without this stage .
Designer:
The Breeder , genetic engineer .
Equivalent to Beth(2+x) in our notation . Humans or proto-humans .
Infinity>= x >=0
This gives a full spectrum of Beth capabilities .
(Negative Beth is outside the scope of this discussion)
Singularities
You will notice that the system becomes chaotically unstable as x->0 from any direction . At that point , the system will exhibit symptoms of great stress and bifurcation . Once over the hump , it steadies either in an evolutionary manner (in
Probability = 1 - ( Beth(n+1)/Beth(n) ) ^0.5 . Admittedly a rough estimate .)
Or in a devolutionary manner , evolutionary manner here described as degrees of complexity .
Stable Gene Engineering :
1.Keep the same Triple-Base Codon Cell-Machinery .
The easiest . Existing cells can be used . Increase the number of bases to 5 .
Then we can optimally reliable make 1/3*5^3 = 40 amino acids + stop + semistart .
Different kinds of Stop and Start would be advisable .
So , maybe 18 new amino acids + 2 different types of Stop + SemiStarts
This would not even be hard .
Well within present technological capability .
(Wanna make an animal with a Kevlar skin ? Well , you can using this method .)
The system would even be self-assembling under the right condition . The main thing is the optimal stability .
This is already evolving as we speak . There a fifth base occasionally involved . So there is a fruitful interaction point .
2.Make 4-Base Codon Cell-Machinery .
A real remake . Not within human capability at the moment .
3.General :
nAminoAcids + nStops + nStarts = 1/3 * ( (nDNA-bases) ^ (nBasesPerCodon) )
where the prefix n denotes "number of"
A further stability would be introduced if nStarts ~ 1/3 * nStops in a fractal fashion .
This because life-forms evolve in a pedal-to-the-metal fashion . The problems are the brakes .
There is a relationship between the Beth level and the nBasesPerCodon . The minimum number sufficient for Beth(2+) is nBasesPerCodon=3 .
Else there is insufficient complexity .
Now go out there and evolve !
Andre .
Wednesday, March 24, 2010
The Beauty of the Genetic Code : An Apology .
An Apology .
Andre Willers.
24 Mar 2010
Synopsis:
I apologise unreservedly for the accellarated changes I have unleashed .
My only excuses are beauty , ignorance and stupidity .
Discussion :
1.Beauty :
The expression from Appendix B says it all . It combines 3 Billion years of evolution with Eulers Constant and quantized signals .
General Genetic Formulation : (from Appendix B)
nAminoAcids + nStops + nStarts = 1/3 * ( (nDNA-bases) ^ (nBasesPerCodon) )
where the prefix n denotes "number of"
Beautiful !
( I was on an endorphin high for 3 days , and still get a glow when I contemplate it.)
2.Ignorance .
This beauty blinded me to my ignorance of the state of the art in work like Jason Chin's at Cambridge . See Appendix A
3.Stupidity :
I should have realized that meta-controls in the genetic code (phene-systems) already made some provision for multiple bases .
The Big Mistake :
Publishing the General Genetic Formulation .
General Genetic Formulation :
nAminoAcids + nStops + nStarts = 1/3 * ( (nDNA-bases) ^ (nBasesPerCodon) )
where the prefix n denotes "number of"
Beautiful !
2/3 of my previous posts were deliberately designed to be slightly ahead of the wave-front of human knowledge , with about 1/3 designed for post-human AI's .
None of them had immediately verifiable feedbacks . The idea was that I would be safely dead when they found out what I actually said , except for some individuals who would mine the insights and take them for their own .
This General Statement is an algorithm to create Stable Neo-Genes . Not just genetic engineering . But Stable Genetic Engineering . Immediately verifiable in expressed genomes .
Oh Well .
I blew it .
What will happen :
See a system like ."Adam and Eve" at Aberystwyth University , Scotland . Dr Amanda Clare . Automated hypothesis formulation and testing . www.computescotland.com/2260.php
Using the General Formulation Algorithm , this system can zero in on stable expressions of any desired genomic code within a week or two . Literally .
Even Lab-on-a-chip can do it within a few months .
This is happening as we speak .
When I realized my mistake (16/3/2010) , I immediately tried to remove the post . Unfortunately , it had already been copied to some genetic engineering websites .
The cat was well and truly out of the bag .
But I still thought that ducking my head under the sand by cutting off all communication would help . Please forgive me for this .
Unfortunately , not only humans would examine my previous posts , but also enhanced humans.
From Appendix A :
See "Pandora bacteria acts as one organism" , NewScientist 27 Feb 2010 , p11.
Electron-conducting protein nanowires link oxygen-poor sub-mud sulfur eating bacteria on the seafloor in an interactive network suggestive of a neural net .
The manufacture of such a protein nanowire would almost certainly require 4-Base Codon cell machinery . Hence the the existence of parallel meta-controls .
These extra-connections can easily be inserted into existing human brains using the above systems , especially about 2-3 years before puberty or in babies .
The capabilities of these systems are equal or greater than my own at present . I cannot predict what will happen , except that it will be very interesting in the Chinese sense .
See posts on AI systems.
Singularity :
I had hoped for a fairly smooth ascent into the singularity , but this is now a pipe dream . There will be fast lurch into human and AI capability , as there is now an arms-race in this type of genome design .
I had hoped to avoid this till a later , more mature stage .
Oh well .
It was the beauty , your honor . The beauty .
Andre
xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Appendix A
Sent 16/3/2010
Hi ,
See ""Rewriting life in four-letter words" , NewScientist 20 Feb 2010 p14.
I just read it (16 Mar 2010) , as I get New Scientist in a haphazard fashion via the library .
See para 2 of original post below
"2.Make 4-Base Codon Cell-Machinery .
A real remake . Not within human capability at the moment ."
I was wrong .
It has already been done by Jason Chin and colleagues at the University of Cambridge . They successfully redesigned some ribosomes and transfer RNA(tRNA) to manufacture a novel amino acid (a novo-calmodulin protein) , expressed via E.Coli .
Important note:
This worked so easily because it worked parallel to the three-Base expression without noticeable inerference .
This hints that the meta-controls (see Phene-system posts) already has provisions for 4-Base cell-machinery .
Hints:
1.See "Pandora bacteria acts as one organism" , NewScientist 27 Feb 2010 , p11.
Electron-conducting protein nanowires link oxygen-poor sub-mud sulfur eating bacteria on the seafloor in an interactive network suggestive of a neural net .
The manufacture of such a protein nanowire would almost certainly require 4-Base Codon cell machinery . Hence the the existence of parallel meta-controls .
Room-temperature organic superconductors seem to be a distinct possibility .
2.Many old-age and degenerative diseases seems remiscent of 4-Base Codon cell machinery activating over time .
But what do I know .
It is your poblem now .
I hope your molecular shamans are better than your climatologist shamans .
Hugga-Bugga!
Andre .
xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Appendix B
-----Original Message-----
Sent: 22 February 2010 08:07 PM
Subject: The Beauty of the Genetic Code .
The Beauty of the Genetic Code .
Andre Willers
22 Feb 2010
Synopsis:
The present TerraIII genetic code is elegantly optimized to give the most robustness possible per unit of information .
Discussion :
You have to be familiar with the concepts in:
1. http://andreswhy.blogspot.com "NewTools:Reserves" and Beth(n) orders of Randomness .
2.NewScientist of 23 Jan 2010 p34 "Another kind of evolution"
Brief recap of Reserves argument :
We take any identifiable entity , slice and dice it with an order of randomness like that of a coin (ie Beth(0) ) . We then calculate a minimum reserve (which is equivalent to the least errors of all possible Beth(0) paths per benefit . )
This works out at 1/3 on the average over Aleph(0) infinities .
The Beauty of the Genetic Code :
Four Base pairs (A,U,C,G) in triplet codons give a possible 4*4*4 = 64 codons .
But together , they code only for 20 amino acids , plus a Stop and a Semi-Start .
This gives
20/64 = 31.22% for 20 amino acids
21/64 = 32.81% for 20 amino acids + Stop
21.3333…/64 = 33.3333… for 20 amino acids + Stop + Semi-Start
22/64 = 34.375 %
Stop = (UGG) , (UGA) , (UAG) ,
Start = (AUG) , but this also codes for methionine . Hence the decimal notation . The system cannot come closer to 1/3 because of quantal considerations . Try it and see .
This also is the portal for the Epigenetic System ( note use of methiolization) .
Beautiful !!
Consider the ways of Gaia .
Linear and Sideways evolution .
Linear :
The standard , gene and chromosome based inheritance
Equivalent to Beth(1+x) in our notation .
1>= x >=0
Sideways :
Genetic material exchanged without going through all that genotype-phenotype procedures .
Equivalent to Beth(1-x) in our notation .
1>= x >=0
Note that the system could not possibly get as close to the optimum reserve without this stage .
Designer:
The Breeder , genetic engineer .
Equivalent to Beth(2+x) in our notation . Humans or proto-humans .
Infinity>= x >=0
This gives a full spectrum of Beth capabilities .
(Negative Beth is outside the scope of this discussion)
Singularities
You will notice that the system becomes chaotically unstable as x->0 from any direction . At that point , the system will exhibit symptoms of great stress and bifurcation . Once over the hump , it steadies either in an evolutionary manner (in
Probability = 1 - ( Beth(n+1)/Beth(n) ) ^0.5 . Admittedly a rough estimate .)
Or in a devolutionary manner , evolutionary manner here described as degrees of complexity .
Stable Gene Engineering :
1.Keep the same Triple-Base Codon Cell-Machinery .
The easiest . Existing cells can be used . Increase the number of bases to 5 .
Then we can optimally reliable make 1/3*5^3 = 40 amino acids + stop + semistart .
Different kinds of Stop and Start would be advisable .
So , maybe 18 new amino acids + 2 different types of Stop + SemiStarts
This would not even be hard .
Well within present technological capability .
(Wanna make an animal with a Kevlar skin ? Well , you can using this method .)
The system would even be self-assembling under the right condition . The main thing is the optimal stability .
This is already evolving as we speak . There a fifth base occasionally involved . So there is a fruitful interaction point .
2.Make 4-Base Codon Cell-Machinery .
A real remake . Not within human capability at the moment .
3.General :
nAminoAcids + nStops + nStarts = 1/3 * ( (nDNA-bases) ^ (nBasesPerCodon) )
where the prefix n denotes "number of"
A further stability would be introduced if nStarts ~ 1/3 * nStops in a fractal fashion .
This because life-forms evolve in a pedal-to-the-metal fashion . The problems are the brakes .
There is a relationship between the Beth level and the nBasesPerCodon . The minimum number sufficient for Beth(2+) is nBasesPerCodon=3 .
Else there is insufficient complexity .
Now go out there and evolve !
Andre .
Andre Willers.
24 Mar 2010
Synopsis:
I apologise unreservedly for the accellarated changes I have unleashed .
My only excuses are beauty , ignorance and stupidity .
Discussion :
1.Beauty :
The expression from Appendix B says it all . It combines 3 Billion years of evolution with Eulers Constant and quantized signals .
General Genetic Formulation : (from Appendix B)
nAminoAcids + nStops + nStarts = 1/3 * ( (nDNA-bases) ^ (nBasesPerCodon) )
where the prefix n denotes "number of"
Beautiful !
( I was on an endorphin high for 3 days , and still get a glow when I contemplate it.)
2.Ignorance .
This beauty blinded me to my ignorance of the state of the art in work like Jason Chin's at Cambridge . See Appendix A
3.Stupidity :
I should have realized that meta-controls in the genetic code (phene-systems) already made some provision for multiple bases .
The Big Mistake :
Publishing the General Genetic Formulation .
General Genetic Formulation :
nAminoAcids + nStops + nStarts = 1/3 * ( (nDNA-bases) ^ (nBasesPerCodon) )
where the prefix n denotes "number of"
Beautiful !
2/3 of my previous posts were deliberately designed to be slightly ahead of the wave-front of human knowledge , with about 1/3 designed for post-human AI's .
None of them had immediately verifiable feedbacks . The idea was that I would be safely dead when they found out what I actually said , except for some individuals who would mine the insights and take them for their own .
This General Statement is an algorithm to create Stable Neo-Genes . Not just genetic engineering . But Stable Genetic Engineering . Immediately verifiable in expressed genomes .
Oh Well .
I blew it .
What will happen :
See a system like ."Adam and Eve" at Aberystwyth University , Scotland . Dr Amanda Clare . Automated hypothesis formulation and testing . www.computescotland.com/2260.php
Using the General Formulation Algorithm , this system can zero in on stable expressions of any desired genomic code within a week or two . Literally .
Even Lab-on-a-chip can do it within a few months .
This is happening as we speak .
When I realized my mistake (16/3/2010) , I immediately tried to remove the post . Unfortunately , it had already been copied to some genetic engineering websites .
The cat was well and truly out of the bag .
But I still thought that ducking my head under the sand by cutting off all communication would help . Please forgive me for this .
Unfortunately , not only humans would examine my previous posts , but also enhanced humans.
From Appendix A :
See "Pandora bacteria acts as one organism" , NewScientist 27 Feb 2010 , p11.
Electron-conducting protein nanowires link oxygen-poor sub-mud sulfur eating bacteria on the seafloor in an interactive network suggestive of a neural net .
The manufacture of such a protein nanowire would almost certainly require 4-Base Codon cell machinery . Hence the the existence of parallel meta-controls .
These extra-connections can easily be inserted into existing human brains using the above systems , especially about 2-3 years before puberty or in babies .
The capabilities of these systems are equal or greater than my own at present . I cannot predict what will happen , except that it will be very interesting in the Chinese sense .
See posts on AI systems.
Singularity :
I had hoped for a fairly smooth ascent into the singularity , but this is now a pipe dream . There will be fast lurch into human and AI capability , as there is now an arms-race in this type of genome design .
I had hoped to avoid this till a later , more mature stage .
Oh well .
It was the beauty , your honor . The beauty .
Andre
xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Appendix A
Sent 16/3/2010
Hi ,
See ""Rewriting life in four-letter words" , NewScientist 20 Feb 2010 p14.
I just read it (16 Mar 2010) , as I get New Scientist in a haphazard fashion via the library .
See para 2 of original post below
"2.Make 4-Base Codon Cell-Machinery .
A real remake . Not within human capability at the moment ."
I was wrong .
It has already been done by Jason Chin and colleagues at the University of Cambridge . They successfully redesigned some ribosomes and transfer RNA(tRNA) to manufacture a novel amino acid (a novo-calmodulin protein) , expressed via E.Coli .
Important note:
This worked so easily because it worked parallel to the three-Base expression without noticeable inerference .
This hints that the meta-controls (see Phene-system posts) already has provisions for 4-Base cell-machinery .
Hints:
1.See "Pandora bacteria acts as one organism" , NewScientist 27 Feb 2010 , p11.
Electron-conducting protein nanowires link oxygen-poor sub-mud sulfur eating bacteria on the seafloor in an interactive network suggestive of a neural net .
The manufacture of such a protein nanowire would almost certainly require 4-Base Codon cell machinery . Hence the the existence of parallel meta-controls .
Room-temperature organic superconductors seem to be a distinct possibility .
2.Many old-age and degenerative diseases seems remiscent of 4-Base Codon cell machinery activating over time .
But what do I know .
It is your poblem now .
I hope your molecular shamans are better than your climatologist shamans .
Hugga-Bugga!
Andre .
xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
Appendix B
-----Original Message-----
Sent: 22 February 2010 08:07 PM
Subject: The Beauty of the Genetic Code .
The Beauty of the Genetic Code .
Andre Willers
22 Feb 2010
Synopsis:
The present TerraIII genetic code is elegantly optimized to give the most robustness possible per unit of information .
Discussion :
You have to be familiar with the concepts in:
1. http://andreswhy.blogspot.com "NewTools:Reserves" and Beth(n) orders of Randomness .
2.NewScientist of 23 Jan 2010 p34 "Another kind of evolution"
Brief recap of Reserves argument :
We take any identifiable entity , slice and dice it with an order of randomness like that of a coin (ie Beth(0) ) . We then calculate a minimum reserve (which is equivalent to the least errors of all possible Beth(0) paths per benefit . )
This works out at 1/3 on the average over Aleph(0) infinities .
The Beauty of the Genetic Code :
Four Base pairs (A,U,C,G) in triplet codons give a possible 4*4*4 = 64 codons .
But together , they code only for 20 amino acids , plus a Stop and a Semi-Start .
This gives
20/64 = 31.22% for 20 amino acids
21/64 = 32.81% for 20 amino acids + Stop
21.3333…/64 = 33.3333… for 20 amino acids + Stop + Semi-Start
22/64 = 34.375 %
Stop = (UGG) , (UGA) , (UAG) ,
Start = (AUG) , but this also codes for methionine . Hence the decimal notation . The system cannot come closer to 1/3 because of quantal considerations . Try it and see .
This also is the portal for the Epigenetic System ( note use of methiolization) .
Beautiful !!
Consider the ways of Gaia .
Linear and Sideways evolution .
Linear :
The standard , gene and chromosome based inheritance
Equivalent to Beth(1+x) in our notation .
1>= x >=0
Sideways :
Genetic material exchanged without going through all that genotype-phenotype procedures .
Equivalent to Beth(1-x) in our notation .
1>= x >=0
Note that the system could not possibly get as close to the optimum reserve without this stage .
Designer:
The Breeder , genetic engineer .
Equivalent to Beth(2+x) in our notation . Humans or proto-humans .
Infinity>= x >=0
This gives a full spectrum of Beth capabilities .
(Negative Beth is outside the scope of this discussion)
Singularities
You will notice that the system becomes chaotically unstable as x->0 from any direction . At that point , the system will exhibit symptoms of great stress and bifurcation . Once over the hump , it steadies either in an evolutionary manner (in
Probability = 1 - ( Beth(n+1)/Beth(n) ) ^0.5 . Admittedly a rough estimate .)
Or in a devolutionary manner , evolutionary manner here described as degrees of complexity .
Stable Gene Engineering :
1.Keep the same Triple-Base Codon Cell-Machinery .
The easiest . Existing cells can be used . Increase the number of bases to 5 .
Then we can optimally reliable make 1/3*5^3 = 40 amino acids + stop + semistart .
Different kinds of Stop and Start would be advisable .
So , maybe 18 new amino acids + 2 different types of Stop + SemiStarts
This would not even be hard .
Well within present technological capability .
(Wanna make an animal with a Kevlar skin ? Well , you can using this method .)
The system would even be self-assembling under the right condition . The main thing is the optimal stability .
This is already evolving as we speak . There a fifth base occasionally involved . So there is a fruitful interaction point .
2.Make 4-Base Codon Cell-Machinery .
A real remake . Not within human capability at the moment .
3.General :
nAminoAcids + nStops + nStarts = 1/3 * ( (nDNA-bases) ^ (nBasesPerCodon) )
where the prefix n denotes "number of"
A further stability would be introduced if nStarts ~ 1/3 * nStops in a fractal fashion .
This because life-forms evolve in a pedal-to-the-metal fashion . The problems are the brakes .
There is a relationship between the Beth level and the nBasesPerCodon . The minimum number sufficient for Beth(2+) is nBasesPerCodon=3 .
Else there is insufficient complexity .
Now go out there and evolve !
Andre .
Tuesday, March 16, 2010
Tornadoes and V1 .
Tornadoes and V1 .
Andre Willers
16 Mar 2010
Synopsis:
A tornado is a vertical pulse jet , like the WWII V1
Discussion :
This is a freebie .
Ever wonder why the V1 motor was mounted on those ridiculous struts?
Because the jet engine generated an enormous torque around the motor . This could only be offset by mounting it off the airfoil controls . See original V1 test-flight data .
But why ?
Examine the V1 design : a valve regulating air intake and chamber explosions , combined with a venturi exhaust .
The valve has to be partly open during most of the intake . This introduces a sideways component to the momentum of the molecules . (a swirl) .
Partly due to gravitational effects and earth-rotational effects , which get amplified .
The added energy of the ignition of the fuel adds to the momentum in all directions . The swirl gets amplified .
The most energetic molecules get to the walls of the reaction chamber first and imparts a torque in abreaction to the bounce . This gets squeezed down in the venture nozzle .
The result is that any pulse-jet engine has a really big torque . A bit counter-intuitive .
Tornado's
The valves and fuel of tornado's are the same : the phase change of water vapour into liquid and water liquid into ice , each releasing a lot of energy , equivalent to the fuel pulses of the V1 . The physical obstruction of water droplets and ice particles act as valves .
The vertical has lots of valves and energy pulses .
The torque translates into the well-known tornado vortex once the contraption gets going .
The exhaust has to go somewhere . It falls down the trailing side of the storm , in pulses . Also called pulsing rear flank downdraft .
See NewScientist 27 Feb 2010 " Storm Chaser" , p40 .
Interventions:
There is not an easy intervention on the energy front , but the system is extraordinarily sensitive on the valve front . Anything making bigger raindrops or bigger haildrops will scale down the tornado effect in a non-linear way .
Hence the use of supersonic shockwaves by Mach 1+ aircraft to sculpt tornado's and hurricanes .
Though barrage of supersonic artillery projectiles fired with a trajectory in the same direction of rotation outside the storm could be used to steer it .
A freebie from Big Windy .
Andre
Andre Willers
16 Mar 2010
Synopsis:
A tornado is a vertical pulse jet , like the WWII V1
Discussion :
This is a freebie .
Ever wonder why the V1 motor was mounted on those ridiculous struts?
Because the jet engine generated an enormous torque around the motor . This could only be offset by mounting it off the airfoil controls . See original V1 test-flight data .
But why ?
Examine the V1 design : a valve regulating air intake and chamber explosions , combined with a venturi exhaust .
The valve has to be partly open during most of the intake . This introduces a sideways component to the momentum of the molecules . (a swirl) .
Partly due to gravitational effects and earth-rotational effects , which get amplified .
The added energy of the ignition of the fuel adds to the momentum in all directions . The swirl gets amplified .
The most energetic molecules get to the walls of the reaction chamber first and imparts a torque in abreaction to the bounce . This gets squeezed down in the venture nozzle .
The result is that any pulse-jet engine has a really big torque . A bit counter-intuitive .
Tornado's
The valves and fuel of tornado's are the same : the phase change of water vapour into liquid and water liquid into ice , each releasing a lot of energy , equivalent to the fuel pulses of the V1 . The physical obstruction of water droplets and ice particles act as valves .
The vertical has lots of valves and energy pulses .
The torque translates into the well-known tornado vortex once the contraption gets going .
The exhaust has to go somewhere . It falls down the trailing side of the storm , in pulses . Also called pulsing rear flank downdraft .
See NewScientist 27 Feb 2010 " Storm Chaser" , p40 .
Interventions:
There is not an easy intervention on the energy front , but the system is extraordinarily sensitive on the valve front . Anything making bigger raindrops or bigger haildrops will scale down the tornado effect in a non-linear way .
Hence the use of supersonic shockwaves by Mach 1+ aircraft to sculpt tornado's and hurricanes .
Though barrage of supersonic artillery projectiles fired with a trajectory in the same direction of rotation outside the storm could be used to steer it .
A freebie from Big Windy .
Andre
The Beauty of the Genetic Code 2
The Beauty of the Genetic Code 2
Andre Willers
16 Mar 2010
Hi ,
See ""Rewriting life in four-letter words" , NewScientist 20 Feb 2010 p14.
I just read it (16 Mar 2010) , as I get New Scientist in a haphazard fashion via the library .
See para 2 of original post below
"2.Make 4-Base Codon Cell-Machinery .
A real remake . Not within human capability at the moment ."
I was wrong .
It has already been done by Jason Chin and colleagues at the University of Cambridge . They successfully redesigned some ribosomes and transfer RNA(tRNA) to manufacture a novel amino acid (a novo-calmodulin protein) , expressed via E.Coli .
Important note:
This worked so easily because it worked parallel to the three-Base expression without noticeable inerference .
This hints that the meta-controls (see Phene-system posts) already has provisions for 4-Base cell-machinery .
Hints:
1.See "Pandora bacteria acts as one organism" , NewScientist 27 Feb 2010 , p11.
Electron-conducting protein nanowires link oxygen-poor sub-mud sulfur eating bacteria on the seafloor in an interactive network suggestive of a neural net .
The manufacture of such a protein nanowire would almost certainly require 4-Base Codon cell machinery . Hence the the existence of parallel meta-controls .
Room-temperature organic superconductors seem to be a distinct possibility .
2.Many old-age and degenerative diseases seems reminiscent of 4-Base Codon cell machinery activating over time .
But what do I know .
It is your poblem now .
I hope your molecular shamans are better than your climatologist shamans .
Hugga-Bugga!
Andre .
-----Original Message-----
The Beauty of the Genetic Code .
Andre Willers
22 Feb 2010
Synopsis:
The present TerraIII genetic code is elegantly optimized to give the most robustness possible per unit of information .
Discussion :
You have to be familiar with the concepts in:
1. http://andreswhy.blogspot.com "NewTools:Reserves" and Beth(n) orders of Randomness .
2.NewScientist of 23 Jan 2010 p34 "Another kind of evolution"
Brief recap of Reserves argument :
We take any identifiable entity , slice and dice it with an order of randomness like that of a coin (ie Beth(0) ) . We then calculate a minimum reserve (which is equivalent to the least errors of all possible Beth(0) paths per benefit . )
This works out at 1/3 on the average over Aleph(0) infinities .
The Beauty of the Genetic Code :
Four Base pairs (A,U,C,G) in triplet codons give a possible 4*4*4 = 64 codons .
But together , they code only for 20 amino acids , plus a Stop and a Semi-Start .
This gives
20/64 = 31.22% for 20 amino acids
21/64 = 32.81% for 20 amino acids + Stop
21.3333…/64 = 33.3333… for 20 amino acids + Stop + Semi-Start
22/64 = 34.375 %
Stop = (UGG) , (UGA) , (UAG) ,
Start = (AUG) , but this also codes for methionine . Hence the decimal notation . The system cannot come closer to 1/3 because of quantal considerations . Try it and see .
This also is the portal for the Epigenetic System ( note use of methiolization) .
Beautiful !!
Consider the ways of Gaia .
Linear and Sideways evolution .
Linear :
The standard , gene and chromosome based inheritance
Equivalent to Beth(1+x) in our notation .
1>= x >=0
Sideways :
Genetic material exchanged without going through all that genotype-phenotype procedures .
Equivalent to Beth(1-x) in our notation .
1>= x >=0
Note that the system could not possibly get as close to the optimum reserve without this stage .
Designer:
The Breeder , genetic engineer .
Equivalent to Beth(2+x) in our notation . Humans or proto-humans .
Infinity>= x >=0
This gives a full spectrum of Beth capabilities .
(Negative Beth is outside the scope of this discussion)
Singularities
You will notice that the system becomes chaotically unstable as x->0 from any direction . At that point , the system will exhibit symptoms of great stress and bifurcation . Once over the hump , it steadies either in an evolutionary manner (in
Probability = 1 - ( Beth(n+1)/Beth(n) ) ^0.5 . Admittedly a rough estimate .)
Or in a devolutionary manner , evolutionary manner here described as degrees of complexity .
Stable Gene Engineering :
1.Keep the same Triple-Base Codon Cell-Machinery .
The easiest . Existing cells can be used . Increase the number of bases to 5 .
Then we can optimally reliable make 1/3*5^3 = 40 amino acids + stop + semistart .
Different kinds of Stop and Start would be advisable .
So , maybe 18 new amino acids + 2 different types of Stop + SemiStarts
This would not even be hard .
Well within present technological capability .
(Wanna make an animal with a Kevlar skin ? Well , you can using this method .)
The system would even be self-assembling under the right condition . The main thing is the optimal stability .
This is already evolving as we speak . There a fifth base occasionally involved . So there is a fruitful interaction point .
2.Make 4-Base Codon Cell-Machinery .
A real remake . Not within human capability at the moment .
3.General :
nAminoAcids + nStops + nStarts = 1/3 * ( (nDNA-bases) ^ (nBasesPerCodon) )
where the prefix n denotes "number of"
A further stability would be introduced if nStarts ~ 1/3 * nStops in a fractal fashion .
This because life-forms evolve in a pedal-to-the-metal fashion . The problems are the brakes .
There is a relationship between the Beth level and the nBasesPerCodon . The minimum number sufficient for Beth(2+) is nBasesPerCodon=3 .
Else there is insufficient complexity .
Now go out there and evolve !
Andre .
Andre Willers
16 Mar 2010
Hi ,
See ""Rewriting life in four-letter words" , NewScientist 20 Feb 2010 p14.
I just read it (16 Mar 2010) , as I get New Scientist in a haphazard fashion via the library .
See para 2 of original post below
"2.Make 4-Base Codon Cell-Machinery .
A real remake . Not within human capability at the moment ."
I was wrong .
It has already been done by Jason Chin and colleagues at the University of Cambridge . They successfully redesigned some ribosomes and transfer RNA(tRNA) to manufacture a novel amino acid (a novo-calmodulin protein) , expressed via E.Coli .
Important note:
This worked so easily because it worked parallel to the three-Base expression without noticeable inerference .
This hints that the meta-controls (see Phene-system posts) already has provisions for 4-Base cell-machinery .
Hints:
1.See "Pandora bacteria acts as one organism" , NewScientist 27 Feb 2010 , p11.
Electron-conducting protein nanowires link oxygen-poor sub-mud sulfur eating bacteria on the seafloor in an interactive network suggestive of a neural net .
The manufacture of such a protein nanowire would almost certainly require 4-Base Codon cell machinery . Hence the the existence of parallel meta-controls .
Room-temperature organic superconductors seem to be a distinct possibility .
2.Many old-age and degenerative diseases seems reminiscent of 4-Base Codon cell machinery activating over time .
But what do I know .
It is your poblem now .
I hope your molecular shamans are better than your climatologist shamans .
Hugga-Bugga!
Andre .
-----Original Message-----
The Beauty of the Genetic Code .
Andre Willers
22 Feb 2010
Synopsis:
The present TerraIII genetic code is elegantly optimized to give the most robustness possible per unit of information .
Discussion :
You have to be familiar with the concepts in:
1. http://andreswhy.blogspot.com "NewTools:Reserves" and Beth(n) orders of Randomness .
2.NewScientist of 23 Jan 2010 p34 "Another kind of evolution"
Brief recap of Reserves argument :
We take any identifiable entity , slice and dice it with an order of randomness like that of a coin (ie Beth(0) ) . We then calculate a minimum reserve (which is equivalent to the least errors of all possible Beth(0) paths per benefit . )
This works out at 1/3 on the average over Aleph(0) infinities .
The Beauty of the Genetic Code :
Four Base pairs (A,U,C,G) in triplet codons give a possible 4*4*4 = 64 codons .
But together , they code only for 20 amino acids , plus a Stop and a Semi-Start .
This gives
20/64 = 31.22% for 20 amino acids
21/64 = 32.81% for 20 amino acids + Stop
21.3333…/64 = 33.3333… for 20 amino acids + Stop + Semi-Start
22/64 = 34.375 %
Stop = (UGG) , (UGA) , (UAG) ,
Start = (AUG) , but this also codes for methionine . Hence the decimal notation . The system cannot come closer to 1/3 because of quantal considerations . Try it and see .
This also is the portal for the Epigenetic System ( note use of methiolization) .
Beautiful !!
Consider the ways of Gaia .
Linear and Sideways evolution .
Linear :
The standard , gene and chromosome based inheritance
Equivalent to Beth(1+x) in our notation .
1>= x >=0
Sideways :
Genetic material exchanged without going through all that genotype-phenotype procedures .
Equivalent to Beth(1-x) in our notation .
1>= x >=0
Note that the system could not possibly get as close to the optimum reserve without this stage .
Designer:
The Breeder , genetic engineer .
Equivalent to Beth(2+x) in our notation . Humans or proto-humans .
Infinity>= x >=0
This gives a full spectrum of Beth capabilities .
(Negative Beth is outside the scope of this discussion)
Singularities
You will notice that the system becomes chaotically unstable as x->0 from any direction . At that point , the system will exhibit symptoms of great stress and bifurcation . Once over the hump , it steadies either in an evolutionary manner (in
Probability = 1 - ( Beth(n+1)/Beth(n) ) ^0.5 . Admittedly a rough estimate .)
Or in a devolutionary manner , evolutionary manner here described as degrees of complexity .
Stable Gene Engineering :
1.Keep the same Triple-Base Codon Cell-Machinery .
The easiest . Existing cells can be used . Increase the number of bases to 5 .
Then we can optimally reliable make 1/3*5^3 = 40 amino acids + stop + semistart .
Different kinds of Stop and Start would be advisable .
So , maybe 18 new amino acids + 2 different types of Stop + SemiStarts
This would not even be hard .
Well within present technological capability .
(Wanna make an animal with a Kevlar skin ? Well , you can using this method .)
The system would even be self-assembling under the right condition . The main thing is the optimal stability .
This is already evolving as we speak . There a fifth base occasionally involved . So there is a fruitful interaction point .
2.Make 4-Base Codon Cell-Machinery .
A real remake . Not within human capability at the moment .
3.General :
nAminoAcids + nStops + nStarts = 1/3 * ( (nDNA-bases) ^ (nBasesPerCodon) )
where the prefix n denotes "number of"
A further stability would be introduced if nStarts ~ 1/3 * nStops in a fractal fashion .
This because life-forms evolve in a pedal-to-the-metal fashion . The problems are the brakes .
There is a relationship between the Beth level and the nBasesPerCodon . The minimum number sufficient for Beth(2+) is nBasesPerCodon=3 .
Else there is insufficient complexity .
Now go out there and evolve !
Andre .
Wednesday, March 03, 2010
Mucal Acoustics.
Mucal Acoustics
Andre Willers
3 Mar 2010
Synopsis:
The Lung Flute .
A really elegant solution to Obstructive Pulmonary phlegm .
A special flute vibrating at 16 Hz dissolves phlegm to be removed by cilia or easy coughing .
Useful for flu , colds , emphysema or chronic bronchitis .
Discussion
See
www.medicalacoustics.com
PopularScience Dec 2009 p32 "The pied piper of mucus" by the inventor Sandy Hawkins .
Cost US$40 .
In use in Japan , Europe , Canada . US FDA approval pending (or already done)
Time needed : time for 20 puffs of air.
Any body who has seen any family member die of emphysema will want one . (Emphysema has inheritable components) .
But it will work just as well for ordinary colds and flu's , instead of expectorants , and cost less . Hypertension patients note .
Expansion :
The principle can be easily expanded into a bio-feedback device that diagnosis and treats at the same time by blowing into the Flute .
Any level of Lab-on-a-chip and electronic diagnostics can be loaded as per price .
Smokers .
Slightly varying resonant frequencies should be able to break up phlegm caused by smoking or pollutant particles (eg diesel) .
Pan and his pipes are usually assiociated with drinking . It seems somehow fitting that smoking should be included .
Really large market .
In heavily polluted areas , it would be more profitable to play the Lung Flute and hydrate heavily than wear ineffective masks .
Sigh .
A sign of the times , when the Lung Flute makes it into the top twenty .
Hats off to Sandy Hawkins .
A really , really elegant solution .
I wish I had thought of it .
Andre
Andre Willers
3 Mar 2010
Synopsis:
The Lung Flute .
A really elegant solution to Obstructive Pulmonary phlegm .
A special flute vibrating at 16 Hz dissolves phlegm to be removed by cilia or easy coughing .
Useful for flu , colds , emphysema or chronic bronchitis .
Discussion
See
www.medicalacoustics.com
PopularScience Dec 2009 p32 "The pied piper of mucus" by the inventor Sandy Hawkins .
Cost US$40 .
In use in Japan , Europe , Canada . US FDA approval pending (or already done)
Time needed : time for 20 puffs of air.
Any body who has seen any family member die of emphysema will want one . (Emphysema has inheritable components) .
But it will work just as well for ordinary colds and flu's , instead of expectorants , and cost less . Hypertension patients note .
Expansion :
The principle can be easily expanded into a bio-feedback device that diagnosis and treats at the same time by blowing into the Flute .
Any level of Lab-on-a-chip and electronic diagnostics can be loaded as per price .
Smokers .
Slightly varying resonant frequencies should be able to break up phlegm caused by smoking or pollutant particles (eg diesel) .
Pan and his pipes are usually assiociated with drinking . It seems somehow fitting that smoking should be included .
Really large market .
In heavily polluted areas , it would be more profitable to play the Lung Flute and hydrate heavily than wear ineffective masks .
Sigh .
A sign of the times , when the Lung Flute makes it into the top twenty .
Hats off to Sandy Hawkins .
A really , really elegant solution .
I wish I had thought of it .
Andre