Optimal AntiOxidants
Andre Willers
25 mar 2013
Synopsis :
Recent research indicates that too much anti-oxidants is
counter productive . 33% of Recommended Daily Allowance is better in normal
cases .
Discussion :
0.This is not medical advice . See your doctor .
1.Too Much anti-oxidants .
Too much anti-oxidants decreases lifespan .
A certain concentration of oxidants are needed to trigger
the various chaperones .
But how much ?
2.For a animal not subject to an acute attack (infection ,
major deficiency disease, etc) we can use the normal Reserve Argument .
See :
The necessary reserve is 1/3 . This is the minimum necessary
sufficient amount .
(Taking 3/3 is like lying on a couch all day and expecting
to grow muscles)
4.Why ?
The cells need some stress to trigger the chaperones , TOR
systems and stem-cell production .
This is from evolutionary reasons . The body does not defend
until it is attacked . But by then it might be too late .
But even a full-scale response to an outside attacker might
be inhibited by too-enthusiastic ingestion of anti-oxidants .
The crash-manufacture of various antibodies will necessitate
some shortcuts involving oxidants . Zapping them is a bit of a no-no .
See Appendix A
5. Adding oxidant stress .
Smoking and drinking alcohol . Both stimulate mTorc1 , as
expected . It stimulates anti-aging and stem-cell production .
The worst thing you can do is take massive anti-oxidants
after the night before . Just keep on
with the normal 1/3 RDA and drink a lot of water .
6.Acute infections .
Why Linus Pauling and Vit C failed :
VitC in 7 gm per dose
killed off intestinal fauna , freeing the immune cells clustered around the
gastro-intestinal tract .
That worked .
But the megadose of
VitC also inhibited chaperone and TOR responses .
Alcohol and nicotine will work better .
A large concentration of alcohol to kill intestinal fauna ,
a nicotine patch to stimulate mTORc1 production .
Then probiotics and chewing gum to restore intestinal fortitude .
7.Personal Stress Trainers .
Well , the rich already have them . Personal exercise
trainers .
But an App can easily be written to do all this .
8.What if there is no RDA ?
Like Resveratrol and numerous other anti-oxidants . Well ,
the manufacturers have no idea either , otherwise they would have stated it . They
just a thumbsuck amount for maximum sales , never mind your health . Unless you
are under acute attack , they can be left out . Take their RDA = 0
9.Exercise :
Exercise is a fundamental stressor .
On a scale of 1-10 , 1-7 (2/3)
is good . More is bad .
A delicious conclusion : very fit people will have to add
some stressors to stay healthy .
This is usually described by a pulse system : In Form , or Out of Form .
There was none of this nonsense with our ancestors . You had
to be fit all the time . So they deliberately added some stressors .
Rotten meat , alcohol , mushrooms , love affairs , religion
, war and peace ,mathematics , novels , poetry ,games , etc
“My horse was out of form “
Ghenghis Khan on losing a battle .
Regards
Andre
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Appendix A
TOR
Andre Willers
4 Feb 2012
Synopsis :
A phene-level metacontrol of
cellular maturity definition .
Discussion :
TOR : Target Of Rapamycin
Rapamycin : a chemical isolated from
the soil of Easter Island (Rapa Nui) in 1972 as a growth inhibitor for fungi
and mammals .
Genes : TOR1 , TOR2 , etc . Genes
that encode for TOR in the form of
TORC1 , TORC2 , etc , which are
complexes of molecules .
These have meta-control functions :
TORC1 , for instance , monitors
nutrient availability and regulates insulin , growth factors , autophagy . Neat
work for a protein .
See Scientific American , Jan 2012
p22 or online .
Too neat . The decision trees are
too large for a single protein .
It is much more likely that some
sort of quorum mechanism is at work , defining the maturity point .
Located on the cell-walls : see
Phene Systems in Appendix I repeated below for your convenience .
The argument is that a very old
mechanism (pre-yeast) can and does regulate DNA and mitochondria mechanisms
(autophagy) . But the critical point is the definition at biochemical level of
maturity.
And it is not a point , but a fuzzy
locus , that can be extended in any direction .
But maturity points would be a
fairly recent invention , in evolutionary terms .
We can see it's effects in early
sexual maturity and dwarfism .
What does this mean to you and me ?
1.Eat mature mushrooms with garlic
butter .
Cooking temperature not to exceed
30C .
This will elongate fuzzy maturity
locus towards the old age direction .(Activates mTORC1)
2.Take MSM and various
micro-nutrients to prevent bottlenecks .
3.Smoke , drink . (Deactivates
mTORC1) .
Use APS and activate other
amygdala's (chakras) .
For the Conspiracy Theorists :
Why was Rapamycin found on Easter
Island ?
Because it was the furthest remove
from human quorum effects .
Their population explosion due to
longevity was due to their remoteness .
Will the same be true of space
colonies ?
The top-knots of the Easter Island
statues were originally anti-agathic suppositories , revamped by a committee of
politicians .
Andre .
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Appendix I
Phene Systems II
Andre
Willers
4 Feb 2011
Synopsis :
Cellular
meta-control mechanisms (Phenes) situated on the cell- and nucleus wall are
expanded on in more depth .
Discussion :
The article
"The Inner life of the Genome" by Tom Miseli in the Feb 2011
Scientific American (p46) pulled together a number threads previously discussed
in this blog .
Briefly , he
found that DNA is organized in the following physical arrangements in a working
cell-nucleus :
DNA ->
Wound around Histone Spools -> Histone Spools fold to form Chromatin strings
-> Heterochromatin strings (a very tightly folded Chromatin strings) (see para
6 below)
Heterochromatin
is so tightly wound that the DNA is inaccessible to transcription factors (ie
inert , switched off) . They are found mostly near the nucleus wall . The
Chromatin strings form delineated tangles , with preferred positions in the
nucleus space .
Near the
center are volumes called Transcription factories .
This is
where the rubber hits the tar .
Volumes rich
in aggregations of cellular components , polymerase enzymes and transcription
factors . How did they get there ? See point 4 below about Chaperones and
Self-organization .
Genes on the
outer Heterochromatin string , on activation from the Phene system , unwinds to
make the DNA accessible . The chromatin string simultaneously also migrates
inward to a transcription factory (presumably triggered by the phene signal)
and gets expressed .
This has
been described as the Histone Code forming the epigenetic system
From
evolutionary considerations , meta-control systems on cell-level and nucleus
level are taken to be related .
Not only are
they descended from the same ur-mechanisms , but if they were not related ,
that would add another expensive translation layer between cell-wall and
nucleus-wall , with concomitant chances of error .
Evolutionary
pressures would have elided any such mutation .
(Sounds
logical , but is it true ? I suspect it is usually true , but exceptions will
be found .
The
perversity of animate matter exceeds that of inanimate matter by orders of
magnitude)
The Histone
System can then be seen as an important subset of the Epigenetic System
But the
epigenetic system can have signals that are not relevant to cells .
See
"Tunneling nanotubes"
See the
following main threads :
Points to
note :
1;
"Distributed viruses" as theorized in "ATP as a
Neurotransmitter" can be better described as pleomorphic organisms as set
out in "Rife and the Histone code"
2;Intralipid
is important because of its ability to hide epigenetic triggers . Notice the
importance of phosphatydilserine (see "Phene Systems") . What would
be the effect of phosphatydilserine with Intralipid-type mechanisms ?
3; Switching
off genes near the cell-wall is a typical evolutionary fail-safe control .
(A process
is inhibited , unless that inhibition is inhibited in turn)
4; When a
gene in the outer-tangle of Heterochromatin strings is activated , the loop it
is in drops in nearer to a Transcription factory .
How does it
know where to go ?
One
theorizes that initially it is self-organizing (ie a hit-or-miss affair) . But
various Beth levels will force an evolution of chaperones (see http://andreswhy.blogspot.com
"Chaperones , Unpacking and Asthma" Aug 2008 )
So , one
envisages a mixture of chaperones(2/3) and self-organization (1/3) (http://andreswhy.blogspot.com
"NewTools reserves" Nov 2008 . Error arguments.)
5;
Chromosome abnormalities (like cancer) . Without a chaperone the dangling loop
is vulnerable to breaking and then joining up with an unsuitable partner . Like
in any bad marriage , the children suffer .
6.Stem Cells
:
The above
description is for a mature , functioning differentiated cell .
Things are
different just before and after divisions .
In Embryonic
stem-cells , there are no Heterochromatin strings .
All the
genes are active , but the shebang is not very robust .
On receiving
a phene-signal to differentiate the cell , lamin proteins are formed and fold
Chromatin strings -> Heterochromatin strings and also tether them to the
nucleus wall . The nucleus becomes much more robust .
Lamin
proteins can then be classified as chaperones .
But notice
how easily nearly any cell can be turned back into a pluripotent cell .
The body
does this all the time (lately , stem cells have been created out of cells
found in urine .This is very unlikely for a storage mechanism .)
From
Wikipedia :
"The nuclear lamina consists of a two-dimensional matrix of proteins located next to
the inner
nuclear membrane.
Thelamin family of proteins make up the matrix and are highly conserved in
evolution. During mitosis, the lamina matrix is reversibly disassembled
as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in
nuclear stability, chromatin structure and gene expression."
The lamins are thriftily reprocessed during
mitosis . This means there is an programmed biological pathway to reverse
differentiation (ie create stem cells) . Which why stem cells are so easily
created .
The only problem now is why the body does not do
it more frequently (ie why grow old?) It seems that the phene system has a
memory , and the new cells after mitosis are reprogrammed .
Any helpful suggestions are welcome .
(Old age sucks.)
7; Heat pulses and Timing .
From para 4
above (Self-organization) , random movement due to heat promotes
self-organization .
The
molecules creating timing mechanisms are evolutionary very old (recent
findings) . Heat pulses at harmonics of the diurnal rhythm should entrain the
self-organizing process and reduce copying errors quite drastically .
(Remember ,
a modest 10 degree Celsius rise in temperature doubles chemical activity on a
molecular level)
The Tea
Ceremony .
An existing
and proven technology .
The number
of seconds in a day = 3^3 * 2^7 * 5^2 = 86 400
Sipping a
very hot liquid every x seconds will pulse with resonances at
X=
2,3,4,5,6, 8,9,10,12.15,16,18,20,24, 25,27,30,… seconds
About 2-3
seconds per sip seems doable . The liquid must be kept hot and the sip rate
maintained . This is ok for stomach systems .
We know
long-term nerve potentiating is about 10 minutes , so if nervous system is
targeted , sip slower (but not longer than 6 seconds between sips) and the tea
must be kept at the same temperature . Eg for 6 seconds between 2.5 ml sip ,
you will drink 10*60/6*2.5 = 250 ml (about one cup .)
Will a Tea
Ceremony with iced tea have the same effect ?
If the
nervous system is targeted , yes . Entrainment is the goal . So the bigger the
temperature difference , more the body will notice . Remember the caffeine .
The maximum
effect if you want to target the nervous system (relax, etc) would be then to
do the Tea Ceremony and make each alternate sip iced tea and very hot tea as
described above . Each in a demi-tasse .
I'm afraid
Tea Ceremony purists in Japan and China will not welcome this conclusion
In other
cases , you can experiment , but I estimate that hot alone will work .
Bar flies ,
hot chocolate and hot/iced coffee I leave for enthusiastic students .
Or else you
can pulse infrared at these rates and frequencies derived from Rife's work
Or else sit
in the sun with a shade that fluctuates (old style Eastern potentate , or
rotating sun-umbrella with variable panels)
Or else
watch TV . Heat radiation on old cathode-ray TV's will resonate at 25 , 27 ,30
times per second .
Children
sitting close will be more susceptible .
Watching TV
on CRT's makes them healthier ? Some independent verification is required
here .
Computer
screens and games ditto .
That was fun
!
Andre
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Appendix A
Phene
Systems.
Andre
Willers
5 Nov 2009
Synopsis :
Cellular-wall
control systems(phenes) of epigenetic and virus systems are becoming known and
described .
Discussion :
See
NewScientist 8 Aug 2009 p 41 "Kills all known germs" by B Holmes .
Relevant
research by Philip Thorpe at University of Texas Southwestern Medical Center in
Dallas .
The argument
is simple :
self-replicating structures started on the walls of bubbles (probably clay :
Gecko life) . These developed into the present day epigenetic control
structures of processes inside the bubbles (ie cells) .
Viruses are
messengers/controls both for intra-cellular and extra-cellular use .
Which is why
they are usually wrapped in variants of the cell-wall .
Phosphatidylserine
:
From the
NewScientist article , this is a molecule mostly found sticking out of the
inner lining of the cell-wall . Virus budding entails that this molecule is
then found in particular patterns sticking out of the outside the outer
cell-wall .
We expect
such a mechanism if the cell-wall harbours the meta-controls (ie epigenetics)
of the cell and some multicellular activity (ie virus messenger generation).
Humans have
created antibodies that inactivate or target-for-destruction the bits of the
Phosphatidylserine molecule sticking out of the cell-wall .
This will
break the feedback-cycle of a large range of harmful viruses (apparently
including HIV , Flu's , some cancers) .
Bavituximab
( a name only a Pharma could love) does exactly this . Expect to see a lot of
it .
The question
is :
Why are
these antibodies not part of the body's normal immune system ?
Answer:
The virus
system is also used for information carrying .
Suppressing
the virus system completely will destroy a multicellular organism , and make it
revert to a collection of individual cells , even down to elemental chemicals
if done properly . (Cf Ebola , SuperEbola , etc)
This can be
bypassed by shining intense , quantum-entangled infra-red light through the
mess (see previous posts) .
The normal
system has to play a delicate balancing act between destruction from bad
viruses and good,communication viruses .
If the
baddies get too big an influence , intervention might be required . This is the
duty of the epigenetic system . Why is it falling down on the job ?
The Dendritic Immune sytem
This is the
connection between the synapse-type learning systems and the phene-system in
the cell walls .
The
dendritic immune system's effectiveness is magnified by at least 3 orders
of magnitude by a continuous sharp pressure-differential . The search space is
drastically reduced by stochastic resonance . (The proof is either immediately
obvious or very long).
Hence modern
music and it's prevalence .
Your chances
of survival is about 10^3 better if you listen to some semi-random rock.
Hence iPod
and others . This is a real effect .
But we can
do better than that by internal Click programming .
You know :
Clicking the tongue , beak , teeth , exoskelet .
There is no
animal with synapses or an immune system that makes no clicks at some stage .
This is
actually quite amazing .
Plants:
We would
then expect plants to be noisy . And they are , on very low frequencies . This
is how desert elephants survive : they hear the bulbous plants growing by the
low-frequency pulses sensed through their feet . A patch of bulbs would have a
signature low-frequency pulse observable from a long way off . (The bulbs would
evolve-learn to spurt growth at the same time . This would lessen the chance of
detection and eating by close-by herbivores not as smart as elephants)
Click-talking
plants .
Better than
just talking to them . But try some castanets . Tap-dancing will work too , but
the neighbours will think you're really crazy tap-dancing to the plants .
Tojours .
Grinding
your teeth .
A common
complaint , usually explained away as stress . Actually , your teeth are trying
to click together . A part of the body's housekeeping routine . Programming the
gums and intestinal tract .
Just for the
hell of it , click your teeth together 5 times together with 5 double-tongue
clicks interspersed as you feel . Count them . You will feel an immediate
stress-relief feeling . Blood pressure will drop . Be careful if medication to
lower blood pressure is taken .
I just
thought of the above , and tried it .
The teeth
(molars mostly) must click against each other . You will notice there is a
damage-control protocol hardwired in . The teeth will click , but not hard
enough to cause damage . This already tells us that this is an old system .
The natural
tendency will be for a double-teeth click , followed by a double tongue-click
with the mouth open . The process then repeats , varying the teeth , tongue and
mouth open/closed .
Be careful
of hypotension of the cardiovascular system . The stress relief is very
pronounced . Especially around the neck and upper shoulder muscles .
Teeth-grinding
should cease .
But why ?
I did not
expect this . But the effect is so pronounced that I cannot ignore it .
The neck and
shoulder muscles do not relax through an effort of will or exercise .
They just relax . (Sort of melt) .
Maybe a
double bite-bite on empty air signals the end of an aggressive episode , and
for expensive fight-or-flight mechanisms to stand down .
This would
make this fairly deep-wired , certainly deeper than psychological stress .
Phene
effects .
The
stand-down is an immediate stand-down , regardless of the number previous
stress-generating events . This must be true , since this is the epigenetic
programming system . There is no other memory system .
Phene
programming of immune-systems , bone-growth , digestion , neural growth etc
,are immediately affected . Genes are switched from crisis to maintenance .
Using the carbohydrate-energy mechanism is a short-term crisis mechanism .
Standing
down the mechanism should ameliorate conditions like Diabetes II .
Or getting
fat .
Want to get
thin ?
The
algorithm :
Double-teeth
click , followed by a double tongue-click with the mouth open . The process
then repeats , varying the teeth , tongue and mouth open/closed .
Repeat
at least ten times a month .
That’s it .
Can it be
this simple?
Yes .
Why has nobody thought of it before ?
As far as I
am aware , nobody in our recorded history has thought that the click of teeth
together can have physiological effects . Prehistoric societies were probably
aware of the effect .
Yet it does
, as you can find out for yourself .
The same for
the simplicity . Simple causes has wide effects , because they are so basic .
You must look at the whole argument .
In any case
, there is hardly any risk .
I am doing
it . Tojours!
Hasta la
vista !
Coming or
going .
Andre .
