6 Oct 2011
A mild selective stasis generator.Good for anti-depressants .
See http://andreswhy.blogspot.com “Melatonin and dinosaurs” Jun 2011
Repeated in Appendix A for ease of reference.
Valdoxane is simply melatonin crippled in very specific ways .The limitation on possible receptor sites enhances some effects like anti-depressants .
Remember , melatonin is the Great Disruptor of feedback effects . That is it's function .
Valdoxane does this , but more effectively .
Rather ho-hum .
Melatonin and Dinosaurs .
14 Jun 2011
"Sleep that knits up the ravell'd sleave of care " Shakespeare
Melatonin ended up in various evolutionary roles because of it's powerful , terminal antioxidant effect . Many neurotransmitters (especially NO classes) can be seen as free radicals . (See Appendix A)
Melatonin is Nature's Terminator . (See Appendix C)
A handy Terminator got roped into being the Enforcer for various feedback systems that had to be kept from repeating .
1.Cancers (eg breast , prostate cancers)
Interruption of signaling molecules .
2.Circadian rhythms of the brain (sleep)
Dismantling runaway feedback systems before they corrupt long-term memory irreparably (sense of self) See Appendix C
3.Gut rhythms :
A separate system Melatonin excretion by various cells and bacteria .
Funnily enough , a separate system . Why ?
Tied to the energy system and things like diabetes .
A sophisticated auto-governor on rates of activity relative to intra-cell position .
Really simple . Really cool . (Think a steam engine's governor) See Appendix B.
As expected , such a powerful terminal antioxidant will also be on the ramparts against foreign invaders (like in the gut)
7 Immune system
Basically a memory system , with potentially unlimited feedback .
Melatonin will terminate this as well , especially in localized , concentrated doses .
But note the correlation between blue-light and HIV .
Very high-intensity pulses of blue light (484 nanometers) or UV should disable the HIV virus .
This is only seven usages .There are probably more . The same concentrations of melatonin cannot serve all .
Hence , melatonin receptors evolved to meter and control cellular responses .
As well as dopsin receptors in the visual systems .
Loss of UV Dopsins
About 100 MYA for mammals . Remnants (melanopsins) are still responsible for nervous system entrainment , but some biological adaptability (ie getting melatonin from diet) was lost .
It also means that humans are especially vulnerable to depression of melatonin production by light in the Blue Wavelengths (484 nanometers) . CFL and LED lights .
This means that you should only use blue lights if you want to be alert . The effect is very strong (about 100 times) .
Interesting , this should be able to be hyperreal . Diffraction patterns (as with insect , bird and reptile scales) could give blue-to UV light that the mammalian optical systems will interpret as hyperreal .And hyperactive .
Mammalian loss of these dopsins are thought to be the result of low level of light on the forest floor .
But what if the scaly animals had evolved to use Blue and UV as a weapon ?
It would have reduced melatonin production even in darkness .
Imagine huge , impregnable Dinosaur behemoths with a skin ecology of luminescent bacteria , the light diffracting from their scales into the blue and UV .
A magnificent sight !
Birds with brilliant UV plumages should have DNA of the lumenifages in suppressed state . Or you can do it the hard way from the skins of late-stage dinosaurs .
Light-flash Extinction :
An amusing thought . The extremely bright flashes of the meteors would have burned out the skin ecology of the dinosaurs , the subsequent darkness sending them into a terminal melatonin deep sleep . See FireFall .
This can be tested . Since melatonin is a terminal antioxidant , the breakdown products should be measurable even after 65 MY .
Chickens and flu's
The diseases can be seen as stripped-down versions of skin-symbiotes of the old dinosaurs . The worst thing you can do is subject them to UV Like in brooders . Self-assembly of old sequences will follow . A very old revenge .
What is a poor mammal to do ?
Because of the very many uses of melatonin , there is no single solution .
Sometimes you need more , sometimes less . The trick is to know when .
Also , the sources depend on light (especially blue light or UV) , gut , immune system , brain , pills(slow release or fast release) etc .
The basic principle is that it stops things dead . Slowly or quickly .
There is a tie-in with the sulfur mechanism that is responsible for the immobilization of all molecular cellular activity (concentrations of H2S about 80 ppm)
Melatonin stops the H2S blockage . At extremely low concentrations .
Look at the molecule .
This is a typical life-system . Blockages of blockages of blockages leading to a system with graduated responses .
Too little melatonin , and H2S is not sufficiently blocked and the organism goes into stasis . Sleep .
Evolved into hibernation . The long light periods led to depletion of melatonin , leading to H2S hibernation . Neat .
SAD is a direct consequence . Too much melatonin leads to neurotransmitter depletion (especially serotonin)
A berserker has to generate high levels of neurotransmitters internally .
Take a pill !
As seen above , the system has many variants . Endo- and exo- just to start with . There are adjuvants (valerian is one) . Epigenetic variants are possible , but this system is so basic that I think adjuvants would give better results .
So , take a pill with timing and accompanying chemicals .
Each one should target a separate system .
The H2S system freezes things . The melatonin system unfreezes it .Pulsing the system enables living and repairing . Sleep with very carefully metered SO2 will enable a very long life for those interested .
Who wants to live forever ?
Besides its function as synchronizer of the biological clock, melatonin also exerts a powerful antioxidant activity. The discovery of melatonin as an antioxidant was made in 1993. In many less complex life forms, this is its only known function. Melatonin is an antioxidantthat can easily cross cell membranes and the blood-brain barrier. Melatonin is a direct scavenger of OH, O2−, and NO. Unlike other antioxidants, melatonin does not undergoredox cycling, the ability of a molecule to undergo reduction and oxidation repeatedly. Redox cycling may allow other antioxidants (such as vitamin C) to act as pro-oxidants, counterintuitively promoting free radical formation. Melatonin, on the other hand, once oxidized, cannot be reduced to its former state because it forms several stable end-products upon reacting with free radicals. Therefore, it has been referred to as a terminal (or suicidal) antioxidant. "
" A potential mechanism is that melatonin promotes the recruitment of brown adipose tissue (BAT) as well as enhances its activity. This effect would raise the basal metabolic rate by stimulating thermogenesis, heat generation through uncoupling oxidative phosphorylation in mitochondria."
"PRC in neurons
Phase response curve analysis can be used to understand the intrinsic properties and oscillatory behavior of regular-spiking neurons. The neuronal PRCs can be classified as being purely positive (PRC type I) or as having negative parts (PRC type II). Importantly, the PRC type exhibited by a neuron is indicative of its input–output function (excitability) as well as synchronization behavior: networks of PRC type II neurons can synchronize their activity via mutual excitatory connections, but those of PRC type I can not.
Experimental estimation of PRC in living, regular-spiking neurons involves measuring the changes in inter-spike interval in response to a small perturbation, such as a transient pulse of current. Notably, the PRC of a neuron is not fixed but may change when firing frequency or neuromodulatory state of the neuron is changed."