Low grade Botulism Poisoning : Alpha Lipoic Acid
(ALA) and Huperzine A as simple amelioratives .
Andre Willers
30 Apr 2013
This is definitely not medical advice . Consult your health
professional .
Synopsis :
Peripheral Neuropathy and Botulism Poisoning both involve
killing the butons in the nerve . Alpha Lipoic Acid and Huperzine A helps to
repair these structures .
Discussion :
1.
Prevent further damage : Huperzine A . See
Appendix B , C and D .
2.
Repair damage already caused : See Appendix A .
3.
Tamoxifen might help : see Appendix E
4.Argument :
ALA definitely helps with Peripheral Neuropathy . (Appendix
A) . The mechanism is still a bit black box .
Botulism poisoning involves the same mechanism (buton
killing) . (Appendix D , E)
This involves the acetylcholinesterase - acetylcholine balance . (Appendix C)
Huperzine A shifts the balance to acetylcholine .
(Appendix B)
When things have gone to hell in a handbasket ,
tamoxifen might help (Appendix E)
5.Low-Grade Nerve-Poisoning from Technology :
(NerveZap)
5.1 Peripheral Neuropathy
.
See Appendix F .
Acrylamide is the main
culprit . Caused by heating food ever 120C . Fire technology .
5.2 Low-grade botulism poisoning
:
A low grade technological
epidemic caused by microwaves and fridges .
Spotty heating by
microwaves , then halting of further botox production by refrigeration .
But every time the food
is taken out of the fridge , a few bugs start multiplying again .
There would be
cross-contamination via utensils as well .
But why doesn’t the
oxygen kill the anaerobic botulism bacteria ?
Because the little bugs don’t kill that easily .
Because little pockets
(micro-droplets) of water of de-oxygenated water shrink-wraps around spores and
even bacteria if the temperature does not destroy them .
Especially in fractal
veggies like cauliflower or broccoli . Unpeeled potato surface micropits .
Even worse , they
re-evolve the ability to switch between anaerobic and aerobic respiration .
The result is a massive , low-grade epidemic of
nerve damage .
6. Personal anecdotal :
My symptoms of low-grade
botox poisoning cleared up dramatically after I chucked
out all suspect foods (we
had trouble with our fridge , but I thought the veggies would be safe) and took
ALA .
Dosage 2X250 ALA per day
.
The effects were dramatic
. 90% of the muscular weakness cleared up in 24 hours .
I did know about Huperzine A then , but will
try it . If it works for Alzheimers , it might help for Parkinsons and Restless
Leg Syndrome .
Tamoxifen I will leave to
the professionals .
7. An interesting aside :
There is a proven
biomedical device for Peripheral Neuropathy
amelioration .
This is a well-known and clinically proven
machine usually touted for pain-relief .
It
should be interesting to see whether it would work with Botox .
If so ,
it would add another very useful chisel to the BioSculptor’s Toolbox.
Between
Botox , ALA , Huperzine A and APS , who needs plastic surgery ?
The
Shapeshifters of Terra strike again !
The
mind boggles.
Regards
Andre
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Appendix A
Mostly about Peripheral Neuropathy (PN) , but ALA helps for
botulinum toxin too .
19246421 In a double blind crossover study in
Taipei of botulinum toxin type A
for diabetic neuropathy, there was significant improvement at 3 months
post-injection.
About US$ 0.14 per 250 mg capsule .
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Appendix B
“Nature also provides nerve gas antitoxins.
Nerve gas interrupts the normal transmission of nerve impulses by altering
levels of acetycholinesterase, the enzyme that degrades the nerve transmitter
acetycholine. Huperzine A, a derivative of Chinese club moss, has been
suggested as a pre-treatment against nerve gases. [Annals Pharmacology France Defense Technical Information Center
“Huperzine A is also an acetylcholinesterase inhibitor, which has a mechanism of action similar to donepezil, rivastigmine, and galantamine. A pro-drug form of huperzine A (ZT-1) is under development
as a treatment for Alzheimer's disease.[3]”
About US$ 0.14 per 200mcg
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Appendix C
Botulinum inhibits the body's production of
acetylcholine within the nervous system, the chemical that produces a bridge
across synapses, where nerve cell axons and dendrites connect with each other.
All forms lead to paralysis that typically
starts with the muscles of the face and then spreads towards the limbs.[10] In severe forms,
it leads to paralysis of the breathing muscles and causesrespiratory failure. In light of this
life-threatening complication, all suspected cases of botulism are treated as medical emergencies, andpublic health officials are
usually involved to prevent further cases from the same source.[10]
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Appendix D
Buton’s :
where Botox and Peripheral Neuronal damage occurs
.
Botox causes destruction (not just paralysis)
of the butons of the peripheral motor nerves. They grown back slowly, which is
why repeated injections 6-18 months later are usually required as well.
What is a buton ?
“Figure 3.1: When the axon arrives at a target
cell it encounters one of the cells
extruded processes - a dendrite- where it makes
a connection. To help things
along the connection is made at a buton, a
micro-extrusion that provides a
site for the connection. As shown, the
collection of dendrites is peppered with
butons, to accommodate the many tens of
thousands of incoming signals.”
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Appendix E
An extreme case . Tamoxifen ?
See http://jnnp.bmj.com/content/55/1/71.full.pdf
. Full blown buton die-off ?
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Appendix F
Peripheral Neuropathy of Legs. A Cure.
Andre
Willers
20 Apr 2010
My Birthday Present to fellow sufferers .
Synopsis:
A
methodology for reducing chronic symptoms (95%)
and repairing nerves .
Summary:
Data
from my personal experience .
1.Use APS
as for lower back pain once a day (8 min) . Unease relief 80%-85% .
2.Use
capsaicum on upper thighs . Before sleep . Unease relief 10% . The need for
this will decrease after about 5-7 usages of APS usage .
3. Keep
blood-glucose concentration <=6.5
4. Do not
eat high acrylamide foods
5.Take
alpha-lipoic acid . 250 mg (1+2+1) per
day initially .Taper .
Beware
reflux . An amusing side effect . Rejection reflexes of crap food are repaired
.
Not beloved
by the fast-food industry .
(Pregnant
women should not take this in large doses. )
Discussion :
The
pathology is caused by damage to the nerves , (especially the long leg-nerves)
by high glucose concentrations in DiabetesII and Acrylamide from diet .
How it works:
The
pain-pulses of damaged nerve A arrive at the synapses in the lower back (spine)
. Here , certain specialized glial cells count the frequency and duration . To
prevent the gate-effect of pain impulses to mask further pain signals of
further tissue damage from other nerves , these cells take on the function of
automatically pulsing pain signals as if from nerve A , while inhibiting the
damaged nerve A's signal .
This
enables other damage signals to come through , preventing further damage .
This has
obvious evolutionary advantages in preventing cascading damages .
The problem
is that , even if damage to nerve A has been repaired , the off-switch of this
mechanism may not work . Or the damage to nerve A might remain .
See http://andreswhy.blogspot.com
"Peripheral Neuropathy" et al .
Chronic
neuropathy results from the inability to activate the "Off" switch in
microglial and astrocyte bodies in the dorsal root ganglion .
See
Scientific American Nov 2009 p 33 .
A further
teensy problem is that , even if there was a temporary repair , if the chronic
condition (like too high glucose or acrylamide concentrations) the microglial
and astrocyte bodies get re-triggered . And they would be sensitized as well .
The Methodology :
1.Drastically
reduce the pain impulses from the microglial and astrocyte bodies in the dorsal
root ganglion . For this we use the APS technology , with electrodes configured
for "Back Pain" .
See http://andreswhy.blogspot.com
"ATP as Neurotransmitter"
I
originally bought this machine in 2001 for Neuropathy leg pains , but put the
electrodes on the legs . This had little or no effect . Only after reading the
article :
See
Scientific American Nov 2009 p 33 did I
realize that the chronic pain is generated in the lower back .
Putting the
electrodes on the sides of the lower hip as recommended for lower back pain led
to a reduction of that chronic burning unease sensation of 80-85 percent.
After about
4-7 days .
Some of the
remainder of unease could be ameliorated by using gate-theory : capsaicum .
Just smear it on the thighs . This generates pain signals that compete at the
lowest spine ganglia , but unfortunately the system habituates easily . .
This brings
us to about 95% of unease .
At least I
could sleep without analgesics .
But there
are still twinges .
The damage
to the nerves still exist . The neuropathic pain will quickly re-establish
itself . We are just managing the condition , not curing it .
The Cure :
Repair the
nerves , while keeping the damaging agents under control .
The
damaging agents are too high concentrations of glucose and acrylamide .
Keep them
under control via diet or insulin .
The repair
is enhanced by alpha-lipoic acid (evening primrose oil).
Take
supplements .
Desensitizing the system :
A really
permanent , buffered system . I do not have that .
Working
,working ….
A promising
lead is propranolol . Reprogramming memories at synapse level (ie the microglial
and astrocyte bodies in the dorsal root ganglion .)
Google
"propranolol PTSD"
Happy
Birthday !
Andre
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