Wednesday, April 17, 2013

Infinite Clones - Never Age


Infinite Clones – Never Age


Andre Willers
17 Apr 2013
Synopsis :
All your cells are but clones of your embryonic cells . The ability to make error-free clones means an anti-ageing system .
Discussion :
1.See Appendix A  and Appendix C . The secret seems to be in the histone , the disruption of the cell membrane when new cell-nucleus is implanted and trichostatin .
2. See appendix D . “However, cloned embryos had more acetyl groups on their histones than normal embryos” . Trichostatin removes acetyl groups on the histone . In other words , it is an epigenetic factor . And a vital one .
3.Disruption of the cell wall . See Appendix E . The control systems for the histone systems sits in the cell-walls . Disrupting them by cutting and implanting a new cell nucleus disrupts the normal counting apparatus . The bath of trichostatin resets it . The histones rewind and move back to near the cell wall . The Pucker-up effect .
4.Nanotech that does this surgery on every cell seems rather crude .
5. We need a lesion on every cell on the body , concomitant with a infusion of trichostatin  , preferably close to cell-division .
6. Luckily we know something that might fit the bill : Bavituximab .
“Phosphatidylserine :
From the NewScientist article , this is a molecule mostly found sticking out of the inner lining of the cell-wall . Virus budding entails that this molecule is then found in particular patterns sticking out of the outside the outer cell-wall .
We expect such a mechanism if the cell-wall harbours the meta-controls (ie epigenetics) of the cell and some multicellular activity (ie virus messenger generation).
Humans have created antibodies that inactivate or target-for-destruction the bits of the Phosphatidylserine molecule sticking out of the cell-wall .
This will break the feedback-cycle of a large range of harmful viruses (apparently including HIV , Flu's , some cancers) .
Bavituximab ( a name only a Pharma could love) does exactly this . Expect to see a lot of it .”
 
7. We can now design a simple anti-agathic .
 Bavituximab plus trichostatin . Dosages to be determined . Hint : use Avogrado’s number . The number of molecules matter .
8. Well , now we can make an error-free copy . But we would really like to stabilize on an optimal physiological age like 26 years .
9. That is why Appendix B is there . Breast milk from a relative is best , but in a pinch any ethnic relative should do .
10 . A true anti-agathic (albeit still simple )
The Recipe :
Bavituximab plus trichostatin plus breast milk stem cells from a relative .
11. Don’t overdo it . I have no idea what will happen if you try to go below ages when brain matter gets reorganised . Does anyone ever want to be a teenager again ?
12. Can this be done into the genes? I really doubt it . This intervention is Beth(1+) . Trying to build it into DNA-Epigenetic-Histone structure will run into some very deep-seated  Gaiean feedback systems . You really don’t want to see an Apoptotic Plague .
13 How green is it ? Very Green .
Green with envy .
 
14. A few thousand years of soapies or scrabbling for food will prepare you for Heaven or Hell , take your pick . Humans will , off course  , alternate .
 
15 . “ No more ducats , but plenty of daughters.” The Merchant of Venice after 10 000 years .
Shakespeare would have loved it .
 
Andre

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Appendix A
Cloning record broken – next up clones from faeces
·         11:54 12 March 2013 by Andy Coghlan and Robert Gilhooly
·         For similar stories, visit the Stem Cells Topic Guide
A mouse has smashed the record for sequential cloning – the ability to make clones of clones of clones. Now the laboratory behind the feat will attempt to make clones from cells extracted from mouse fur, stuffed bodies and excrement.
Teruhiko Wakayama at the RIKEN Center for Developmental Biology in Kobe, Japan, who carried out the work, says the technique could help in producing high-quality animals for farms and conservation purposes. "If a 'super cow' that could produce a lot of milk or Kobe beef could be cloned at low cost, then not only consumers but also farmers would be happy," he says.
Twenty-five generations of clones have come from the mouse, and all 580 of them were healthy, lived normal lifespans and could have healthy pups through normal mating.
In 2008, Wakayama's team produced clones from dead mice that had been frozen for 16 years. "My lab is now trying to make cloned mice from fur, stuffed bodies, and excrement," says Wakayama.
Third-generation clone
Enthusiasm for therapeutic cloning, as the technique that led to Dolly the sheep is knownwaned in the mid-2000s following scientific fraud scandals in South Korea and the difficulty of producing animals without abnormalities. Researchers struggled to produce cloned cattle, pigs, cats and dogs beyond two or three generations.
Now Wakayama's team has emphatically broken through this barrier thanks to a chemical which more faithfully resets the cell nucleus to be cloned back to an embryonic state.
First, the team emptied a mouse egg cell of its nucleus. Then they inserted a nucleus from the adult mouse to be cloned before putting this cell into a bath of an enzyme blocker called trichostatin. The resulting embryos – all females – had fewer abnormalities in their histones, the packing materials for chromosomes.
Previous studies had identified faulty histones in cloned embryos as a possible reason for the poor success rate of cloning, as well as clone abnormalities. A possible explanation for the previous limit on the number of "reclones" is a build up of such abnormalities over successive generations.
Game changer
"So far, nobody has been able to explain the reason for this," says Wakayama. "We thought that this limitation was caused by the accumulation of genetic or epigenetic abnormalities."
"This is very impressive work. If this translates to other mammalian species – including humans – it could be a major game changer," says Robert Lanza, chief medical officer at Advanced Cell Technology, a company based in Marlborough, Massachusetts, that is developing treatments based on stem cells.
Wakayama says he doesn't know if his technique will make it easier to clone primates, let alone humans, and has no plans to try. "I am a mouse researcher and have no experience with other species. I will not even attempt to use rats, because male rats are extremely difficult to clone."
One application of cloning is to preserve endangered species, as advocated late last year by Brazil. The ability to make clones from fur, specimens preserved in museums and excrement would potentially allow the "resurrection" of extinct animals.
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Appendix B
Are breast milk stem cells the real deal for medicine?
·         14 March 2013 by Douglas Heaven
·         Magazine issue 2908Subscribe and save
·         For similar stories, visit the Stem Cells Topic Guide
PROTEINS, carbohydrates and vitamins are all on the menu for a breastfed baby. Now it seems you can add stem cells to that list. Evidence is piling up that both breast milk and breast tissue contain embryonic-like stem cells.
That might mean we will soon have access to a source of stem cells without destroying embryos. This would be a boon as stem cells can turn into any type of human tissue, making them useful for treating degenerative diseases like Alzheimer's or for regrowing damaged heart muscle.
In 2011 Foteini Hassiotou at the University of Western Australia in Crawley and colleagues found stem cells in lactating breast tissue and breast milk. When they grew the breast milk cells they turned into the three types of cells from which all tissues and organs develop – just like human embryonic stem cells (hESCs) do.
Hassiotou has since found this "pluripotency" in many more breast milk samples and thinks that breast milk stem cells could one day replace those from embryos. In one study, her team looked at fresh breast milk from more than 70 healthy breastfeeding women. They found that BMSCs expressed several genes that are also found in hESCs and help them replicate. Cultured samples also grew into different tissues including bone, neuron, heart and pancreatic cells (Human Lactation, DOI: 10.1177/0890334413477242).
In some cases, the team found that 30 per cent of all cells in breast milk were stem cells. In studies with monkeys and mice the cells were shown to pass into the bloodstream.
"One can speculate wildly about what they do in the baby," says Hassiotou. But she thinks that breastfed infants could be getting a developmental head start, with stem cells from the mother contributing to organ development in the newborn.
However, BMSCs fail one widely accepted test for embryonic cells: when injected into mice, they don't form a type of tumour called a teratoma. For many this failure is a deal-breaker.
But BMSCs are not alone. Mari Dezawa at Tohuku University in Sendai, Japan, and colleagues have found pluripotent cells called MUSE cells in bone marrow and connective tissue that do not form teratomas.
"The best stem cells might not make tumours," says Hassiotou. Dezawa agrees, and says that MUSE and BMSCs could be superior if they turn into a wide variety of cells without the risk of forming tumours.
Thea Tlsty at the University of California in San Francisco says she can imagine that there are pluripotent cells that do not make tumours. Her team recently identified pluripotent stem cells in breast tissue from non-lactating women and men (PNASdoi.org/krn). Although her cells do form tumours, she agrees that the standard test needs revisiting.
Tlsty is not convinced that BMSCs are truly pluripotent, since they have yet to be shown to differentiate fully into living tissue. Nevertheless, she is open-minded. It used to be thought that these cells were restricted to the testes or ovaries, "now we're finding them all over the body".
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Appendix C
Trichostatin A (TSA) is an organic compound that serves as an antifungal antibiotic and selectively inhibits the class I and II mammalian histone deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., Sirtuins).[1] TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage. TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones (histone deacetylases, HDAC) and therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin. It is a member of a larger class ofhistone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Thus, TSA has some potential as an anti-cancerdrug.[2] One suggested mechanism is that TSA promotes the expression of apoptosis-related genes, leading to cancerous cells surviving at lower rates, thus slowing the progression of cancer.[3] Other mechanisms may include the activity of HDIs to induce cell differentiation, thus acting to "mature" some of the de-differentiated cells found in tumors. HDIs have multiple effects on non-histone effector molecules, so the anti-cancer mechanisms are truly not understood at this time.
TSA inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.[4]
TSA represses IL (interleukin)-1β/LPS (lipopolysaccharide)/IFNγ (interferon γ)-induced nitric oxide synthase (NOS)2 expression in murine macrophage-like cells but increases LPS-stimulated NOS2 expression in murine N9 and primary rat microglial cells.[5]
However, there are few if any clinical trials of TSA.[6]
[edit]See also
·         Histone deacetylase inhibitor
·         Vorinostat (SAHA)
·         Moon C, Kim SH (June 2009). "Use of epigenetic modification to induce FOXP3 expression in naïve T cells". Transplant Proc. 41 (5): 1848–54.doi:10.1016/j.transproceed.2009.02.101PMID 19545742.
[edit]

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Appendix D
Glimpse into cloned embryos reveals problems
·         16:46 30 June 2004 by Claire Ainsworth, Berlin
A glimpse of what happens to the DNA in a cell nucleus during cloning has been revealed by US researchers. They hope their work will shed light on why cloning creates abnormalities and whether fears about IVF techniques causing abnormalities in children are justified.
Cloned animals are often born with birth defects, such as "large offspring syndrome" where the animals are born much bigger than normal. These defects are linked to problems with imprinting, the chemical marks on chromosomes that govern the activity of genes.
Recently, a number of reports have claimed that the rates of human imprinting disorders are higher in children conceived using artificial methods, such as IVF and ICSI. One of these disorders, Beckwith-Wiedemann Syndrome, results in babies being born abnormally large.
Takumi Takeuchi and Gianpiero Palermo from Cornell University in New York decided to investigate what happens to the DNA of mouse embryos produced via artificial methods and cloning.
They compared mouse embryos conceived naturally with ICSI embryos, parthenogenetic embryos - created by stimulating an egg to divide without being fertilised by sperm - and embryos made by cloning, i.e. adding an adult cell nucleus to an egg that has had its DNA removed.
Modified behaviour
The team looked at the structure of proteins called histones in all these embryos. Histones help package DNA into chromosomes, and also influence the activity of genes. Cells add or remove different chemical groups to these histones to modify the behaviour of their genes. Histones in adult cells have very different patterns of chemical groups to those in embryonic ones.
Takeuchi and his colleagues looked at these chemical groups with the help of antibodies attached to fluorescent dyes. They found that the chemical marks on the histones of the nucleus in the cloned embryos was initially completely re-set, resembling the pattern seen in a mature egg nucleus.
This means that mature eggs have the ability to reprogram this aspect of an adult nucleus's behaviour, he told the annual conference of the European Society for Human Reproduction and Embryology in Berlin, Germany, on Wednesday.
"We don't know what it means yet," Palermo told New Scientist. Clearly, the egg has taken the nucleus back towards a more immature state, but the extent of the re-setting is unclear. "Whether it is correctly reprogrammed, we don't know."
Abnormal activity
Takeuchi also found that at a later stage of development, the histones of ICSI and parthenogenetic embryos behaved in the same way as naturally conceived embryos.
However, cloned embryos had more acetyl groups on their histones than normal embryos, suggesting that the activity of their genes was abnormal.
This correlated well with the team's finding that only 30 per cent of the cloned embryos reached a later stage of development called a blastocyst. The parthenogenetic and ICSI embryos achieved that stage at a similar rate to naturally conceived embryos.
"We found significantly impaired development in the cloned embryos compared with those derived from more conventional assisted reproductive technologies," said Takeuchi. "And this has made us more convinced that reproductive cloning is unsafe and should not be applied to humans."
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Appendix E

Phene Systems II

Andre Willers
4 Feb 2011

Synopsis :
Cellular meta-control mechanisms (Phenes) situated on the cell- and nucleus wall are expanded on in more depth .

Discussion :

The article "The Inner life of the Genome" by Tom Miseli in the Feb 2011 Scientific American (p46) pulled together a number threads previously discussed in this blog .

Briefly , he found that DNA is organized in the following physical arrangements in a working cell-nucleus :
DNA -> Wound around Histone Spools -> Histone Spools fold to form Chromatin strings -> Heterochromatin strings (a very tightly folded Chromatin strings) (see para 6 below)

Heterochromatin is so tightly wound that the DNA is inaccessible to transcription factors (ie inert , switched off) . They are found mostly near the nucleus wall . The Chromatin strings form delineated tangles , with preferred positions in the nucleus space .

Near the center are volumes called Transcription factories .
This is where the rubber hits the tar .
Volumes rich in aggregations of cellular components , polymerase enzymes and transcription factors . How did they get there ? See point 4 below about Chaperones and Self-organization .

Genes on the outer Heterochromatin string , on activation from the Phene system , unwinds to make the DNA accessible . The chromatin string simultaneously also migrates inward to a transcription factory (presumably triggered by the phene signal) and gets expressed .
This has been described as the Histone Code forming the epigenetic system

From evolutionary considerations , meta-control systems on cell-level and nucleus level are taken to be related .
Not only are they descended from the same ur-mechanisms , but if they were not related , that would add another expensive translation layer between cell-wall and nucleus-wall , with concomitant chances of error .
Evolutionary pressures would have elided any such mutation .

(Sounds logical , but is it true ? I suspect it is usually true , but exceptions will be found .
The perversity of animate matter exceeds that of inanimate matter by orders of magnitude)

The Histone System can then be seen as an important subset of the Epigenetic System
But the epigenetic system can have signals that are not relevant to cells .
See "Tunneling nanotubes"

See the following main threads :
http://andreswhy.blogspot.com "Rife and the Histone Code" Jan 2011
http://andreswhy.blogspot.com "Phene System" Nov 2009 (reproduced in Appendix A below for convenience .)
http://andreswhy.blogspot.com "ATP as a neurotransmitter" Jan 2010
http://andreswhy.blogspot.com "Tunneling nanotubes" Nov 2010
http://andreswhy.blogspot.com "Coffee foam" Aug 2009
http://andreswhy.blogspot.com "Intralipid II" Feb 2011
http://andreswhy.blogspot.com "Chaperones , Unpacking and Asthma" Aug 2008

Points to note :
1; "Distributed viruses" as theorized in "ATP as a Neurotransmitter" can be better described as pleomorphic organisms as set out in "Rife and the Histone code"

2;Intralipid is important because of its ability to hide epigenetic triggers . Notice the importance of phosphatydilserine (see "Phene Systems") . What would be the effect of  phosphatydilserine with Intralipid-type mechanisms ?

3; Switching off genes near the cell-wall is a typical evolutionary fail-safe control .
(A process is inhibited , unless that inhibition is inhibited in turn)

4; When a gene in the outer-tangle of Heterochromatin strings is activated , the loop it is in drops in nearer to a Transcription factory .
How does it know where to go ?
One theorizes that initially it is self-organizing (ie a hit-or-miss affair) . But various Beth levels will force an evolution of chaperones (see http://andreswhy.blogspot.com "Chaperones , Unpacking and Asthma" Aug 2008 )
So , one envisages a mixture of chaperones(2/3) and self-organization (1/3) (http://andreswhy.blogspot.com "NewTools reserves" Nov 2008 . Error arguments.)

5; Chromosome abnormalities (like cancer) . Without a chaperone the dangling loop is vulnerable to breaking and then joining up with an unsuitable partner . Like in any bad marriage , the children suffer .

6.Stem Cells :
The above description is for a mature , functioning differentiated cell .
Things are different just before and after divisions .
In Embryonic stem-cells , there are no Heterochromatin strings .
All the genes are active , but the shebang is not very robust .

On receiving a phene-signal to differentiate the cell , lamin proteins are formed and fold Chromatin strings -> Heterochromatin strings and also tether them to the nucleus wall . The nucleus becomes much more robust .
Lamin proteins can then be classified as chaperones .
But notice how easily nearly any cell can be turned back into a pluripotent cell .
The body does this all the time (lately , stem cells have been created out of cells found in  urine .This is very unlikely for a storage mechanism .)

From Wikipedia :
"The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. Thelamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression."

The lamins are thriftily reprocessed during mitosis . This means there is an programmed biological pathway to reverse differentiation (ie create stem cells) . Which why stem cells are so easily created .

The only problem now is why the body does not do it more frequently (ie why grow old?) It seems that the phene system has a memory , and the new cells after mitosis are reprogrammed .

Any helpful suggestions are welcome .
(Old age sucks.)

7; Heat pulses and Timing .
From para 4 above (Self-organization) , random movement due to heat promotes self-organization .
The molecules creating timing mechanisms are evolutionary very old (recent findings) . Heat pulses at harmonics of the diurnal rhythm should entrain the self-organizing process and reduce copying errors quite drastically .
(Remember , a modest 10 degree Celsius rise in temperature doubles chemical activity on a molecular level)

The Tea Ceremony .
An existing and proven technology .

The number of seconds in a day = 3^3 * 2^7 * 5^2 = 86 400
Sipping a very hot liquid every x seconds will pulse with resonances at
X= 2,3,4,5,6, 8,9,10,12.15,16,18,20,24, 25,27,30,… seconds
About 2-3 seconds per sip seems doable . The liquid must be kept hot and the sip rate maintained . This is ok for stomach systems .

We know long-term nerve potentiating is about 10 minutes , so if nervous system is targeted , sip slower (but not longer than 6 seconds between sips) and the tea must be kept at the same temperature . Eg for 6 seconds between 2.5 ml sip , you will drink 10*60/6*2.5 = 250 ml (about one cup .) 

Will a Tea Ceremony with iced tea have the same effect ?
If the nervous system is targeted , yes . Entrainment is the goal . So the bigger the temperature difference , more the body will notice . Remember the caffeine .

The maximum effect if you want to target the nervous system (relax, etc) would be then to do the Tea Ceremony and make each alternate sip iced tea and very hot tea as described above . Each in a demi-tasse .

I'm afraid Tea Ceremony purists in Japan and China will not welcome this conclusion


In other cases , you can experiment , but I estimate that hot alone will work .

Bar flies , hot chocolate and hot/iced coffee I leave for enthusiastic students .

Or else you can pulse infrared at these rates and frequencies derived from Rife's work

Or else sit in the sun with a shade that fluctuates (old style Eastern potentate , or rotating sun-umbrella with variable panels)

Or else watch TV . Heat radiation on old cathode-ray TV's will resonate at 25 , 27 ,30 times per second .
Children sitting close will be more susceptible .
Watching TV on CRT's makes them healthier ?  Some independent verification is required here .
Computer screens and games ditto .

That was fun !

Andre

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Appendix A

Phene Systems.
Andre Willers
5 Nov 2009

Synopsis :
Cellular-wall control systems(phenes) of epigenetic and virus systems are becoming known and described .

Discussion :
See NewScientist 8 Aug 2009 p 41 "Kills all known germs" by B Holmes .
Relevant research by Philip Thorpe at University of Texas Southwestern Medical Center in Dallas .

See also  http://andreswhy.blogspot.com "Coffee Foam" 2 Aug 2009 and later .

The argument is simple : self-replicating structures started on the walls of bubbles (probably clay : Gecko life) . These developed into the present day epigenetic control structures of processes inside the bubbles (ie cells) .
Viruses are messengers/controls both for intra-cellular and extra-cellular use .
Which is why they are usually wrapped in variants of the cell-wall .

Phosphatidylserine :
From the NewScientist article , this is a molecule mostly found sticking out of the inner lining of the cell-wall . Virus budding entails that this molecule is then found in particular patterns sticking out of the outside the outer cell-wall .

We expect such a mechanism if the cell-wall harbours the meta-controls (ie epigenetics) of the cell and some multicellular activity (ie virus messenger generation).

Humans have created antibodies that inactivate or target-for-destruction the bits of the Phosphatidylserine molecule sticking out of the cell-wall .

This will break the feedback-cycle of a large range of harmful viruses (apparently including HIV , Flu's , some cancers) .
Bavituximab ( a name only a Pharma could love) does exactly this . Expect to see a lot of it .

The question is :
Why are these antibodies not part of the body's normal immune system ?
Answer:
The virus system is also used for information carrying .

Suppressing the virus system completely will destroy a multicellular organism , and make it revert to a collection of individual cells , even down to elemental chemicals if done properly . (Cf Ebola , SuperEbola ,  etc)

This can be bypassed by shining intense , quantum-entangled infra-red light through the mess (see previous posts) .

The normal system has to play a delicate balancing act between destruction from bad viruses and good,communication viruses .

If the baddies get too big an influence , intervention might be required . This is the duty of the epigenetic system . Why is it falling down on the job ?

The Dendritic Immune sytem

This is the connection between the synapse-type learning systems and the phene-system in the cell walls .

The dendritic immune  system's effectiveness is magnified by at least 3 orders of magnitude by a continuous sharp pressure-differential . The search space is drastically reduced by stochastic resonance . (The proof is either immediately obvious or very long).

Hence modern music and it's prevalence .

Your chances of survival is about 10^3 better if you listen to some semi-random rock.
Hence iPod and others . This is a real effect .

But we can do better than that by internal Click programming .
You know : Clicking the tongue , beak , teeth , exoskelet .

There is no animal with synapses or an immune system that makes no clicks at some stage .
This is actually quite amazing .

Plants:
We would then expect plants to be noisy . And they are , on very low frequencies . This is how desert elephants survive : they hear the bulbous plants growing by the low-frequency pulses sensed through their feet . A patch of bulbs would have a signature low-frequency pulse observable from a long way off . (The bulbs would evolve-learn to spurt growth at the same time . This would lessen the chance of detection and eating by close-by herbivores not as smart as elephants)

Click-talking plants .
Better than just talking to them . But try some castanets . Tap-dancing will work too , but the neighbours will think you're really crazy tap-dancing to the plants . Tojours .

Grinding your teeth .
A common complaint , usually explained away as stress . Actually , your teeth are trying to click together . A part of the body's housekeeping routine . Programming the gums and intestinal tract .

Just for the hell of it , click your teeth together 5 times together with 5 double-tongue clicks interspersed as you feel . Count them . You will feel an immediate stress-relief feeling . Blood pressure will drop . Be careful if medication to lower blood pressure is taken .

I just thought of the above , and tried it .
The teeth (molars mostly) must click against each other . You will notice there is a damage-control protocol hardwired in . The teeth will click , but not hard enough to cause damage . This already tells us that this is an old system .

The natural tendency will be for a double-teeth click , followed by a double tongue-click with the mouth open . The process then repeats , varying the teeth , tongue and mouth open/closed .

Be careful of hypotension of the cardiovascular system . The stress relief is very pronounced . Especially around the neck and upper shoulder muscles .

Teeth-grinding should cease .

But why ?

I did not expect this . But the effect is so pronounced that I cannot ignore it .
The neck and shoulder muscles do not relax through  an effort of will or exercise . They just relax . (Sort of melt) .

Maybe a double bite-bite on empty air signals the end of an aggressive episode , and for expensive fight-or-flight mechanisms to stand down .

This would make this fairly deep-wired , certainly deeper than psychological stress .

Phene effects .
The stand-down is an immediate stand-down , regardless of the number previous stress-generating events . This must be true , since this is the epigenetic programming system . There is no other memory system .

Phene programming of immune-systems , bone-growth , digestion , neural growth etc ,are immediately affected . Genes are switched from crisis to maintenance . Using the carbohydrate-energy mechanism is a short-term crisis mechanism .

Standing down the mechanism should ameliorate conditions like Diabetes II .

Or getting fat .

Want to get thin ?
The algorithm :
Double-teeth click , followed by a double tongue-click with the mouth open . The process then repeats , varying the teeth , tongue and mouth open/closed .
Repeat  at least ten times a month .
That’s it .


Can it be this simple?
Yes .

Why has nobody thought of it before ?

As far as I am aware , nobody in our recorded history has thought that the click of teeth together can have physiological effects . Prehistoric societies were probably aware of the effect .

Yet it does , as you can find out for yourself .
The same for the simplicity . Simple causes has wide effects , because they are so basic . You must look at the whole argument .

In any case , there is hardly any risk .
I am doing it . Tojours!

Hasta la vista !
Coming or going .

Andre .
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