Immortality Update 6
: IGF-1
Andre Willers
31 May 2014
“Hope is always desperate.”
Synopsis :
We stimulate liver production of IGF-1 directly via random
secretagogue production, bypassing the HGH mechanism . We hope that functional
selectivity keeps the contraption within survivable boundaries .
Discussion :
1.HGH (Human Growth Hormone) regulates cellular division and
apoptosis . How you live , grow and die .
2. The major tool is IGF-1 (Insulin Like Factor- 1) ,
produced in the liver .
See Appendix BB
Notice the Grandmother (age 75) and Grandfather (age 65) effects .
3.HGH secretagogues are very expensive and not all that
effective . Ditto actual HGH .
Because all the control factors are absent .
4. So we simply
shotgun it .
We use the technique (psyllium husk reaction chambers and
microwaves) as set out in Appendix CC to produce a very large range of
bio-reactive materials from known liver
activators .
We simply semi-randomly create a large variety of HGH
related molecules and let God sort them out .
An adult dosage for about male age 65 should do . ( 400 mg
in powder and/or extract form .)
5. There must be deleterious materials in them . So ,we rely
on selective receptor modulators to weed out the
dangerous ones . See Appendix AA .
These also serve as innoculators .
6. Precise targeting :
Simply spit into the original sample . DNA and epigenetics
serve as templates for amplification in reaction chambers . (The Gothic
inclined can use a drop a blood )
7. Will PCR techniques help ?
If a DNA sample is included , it probably would .
8. The Kitchen Recipe :
8.1 Mix a ½ teaspoon of Psyllium husks with the 400 gm milk
thistle extract with 100 ml water .
8.2 Spit in it (If you are doing DNA targeting) . Mix .
Stand for 10 minutes to allow population of reaction chambers . Then PCR it .
This is but a primitive sketch , suitable for a kitchen .
8.3 PCR Start cycle:
8.3.1 Microwave till 95 C
8.3.2 Cool till 60 C
8.3.3 Microwave till 72 C
End cycle .
8.4 Number of cycles:
For this sort of purpose , 3-8 cycles should suffice .
8. How safe is this ?
Not very .
From Appendix BB , there seems to be a reasonable
expectation of something happening .
But the odds favour that it would be bad , except for functional
selectivity .
A sort of Darwin’s Daemon
, that lets only beneficial mutagens pass . Also known as the immune
system .
Well , you certainly will stimulate your immune system out
of its torpor .
9.You have to be desperate , or trying for the Darwin award
to do this in your kitchen without proper safeguards .
10 . But , if you are terminal from cancer , old age , etc ,
you might as well go out fighting .
Who knows ?
Your immune system might learn to sing . Just like the horse
.
And this a real Picasso sketch . Alien envy .
Have fun !
Andre
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Appendix AA
New findings that broaden the conventional
definition of pharmacology demonstrate that ligands can concurrently behave as
agonist andantagonists at the same receptor, depending on effector
pathways or tissue type. Terms that describe this phenomenon are "functional
selectivity", "protean agonism",[4][5] or selective receptor modulators.[6]
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Appendix BB
Notice Grandmother Effect after age 75 for females .
Notice new lease on life after age 65 for males (this was
not expected) .Grandfather Effect ?
|
Max 5
|
Max IGF-1
|
IGF-1
|
Max 5
|
Max IGF-1
|
IGF-1
|
|
|
Age male
|
ng/mL
|
Extra
|
Age female
|
ng/mL
|
Extra
|
|
|
25
|
344
|
0
|
25
|
323
|
21
|
|
|
30
|
275
|
69
|
30
|
271
|
73
|
|
|
35
|
241
|
103
|
35
|
244
|
100
|
|
|
40
|
226
|
118
|
40
|
225
|
119
|
|
|
45
|
210
|
134
|
45
|
205
|
139
|
|
|
50
|
201
|
143
|
50
|
194
|
150
|
|
|
55
|
201
|
143
|
55
|
191
|
153
|
|
|
60
|
194
|
150
|
60
|
173
|
171
|
|
|
65
|
191
|
153
|
65
|
168
|
176
|
|
|
70
|
195
|
149
|
70
|
168
|
176
|
|
|
75
|
187
|
157
|
75
|
166
|
178
|
|
|
80
|
184
|
160
|
80
|
168
|
176
|
|
|
85
|
182
|
162
|
85
|
179
|
165
|
|
|
90
|
182
|
162
|
90
|
179
|
165
|
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Appendix CC
Friday, May 30, 2014
Stability of Water .
Andre Willers
30 May 2014
Synopsis :
Water and doped water has many discontinuous metastability
regions . There are many economic applications .
Discussion :
1.Concept of metastability : http://en.wikipedia.org/wiki/Metastability
Note that metastable states then have finite
boundary levels .
Lower entropy is maintained in a domain because of
lack of a triggering mechanism .
Well known example : leave a cup of water in a
microwave too long . If you disturb it , it boils over .
The water was in a metastable state .
2. What does this mean ?
It means that we can lock in higher energy states
(like a battery) or information (like molecule shapes) by using the
metastability of water .
3. There are three factors that affect the stability
states : Pressure , temperature and time .
4.Shockwaves :
These manipulate all three .
A shockwave increases/decreases pressure , and
temperature , more rapidly than normal .
5. During this , as the shockwave passes , many
different stability states are created .
6. Repeated shockwaves at the correct frequency
increases the chosen stability state .
Stability bubbles will coalesce .
(A quantum effect . Might even be resonance at a
distance . FTL communication ?)
7. Doped water .
Plain H2O then has memory of a limited kind , and
duration (about 256 bits per phase transition)
But if it contains matter , especially deliciously
resonant organic molecules , the number of metastable states increase by at
least 3^(3^3) ~ 7.625 x 10^12 times .
This is about 1.952 x 10^15 bits .
The human mind is estimated to contain about 8.796
x 10^14 bits .
Doped water in a neuronal cell then contains an
order of magnitude greater computational ability than the whole organism .
Does this make sense ?
Yes .
Also called the unconscious mind .
Distributed hierarchical computing .
And you are the pinnacle of that achievement !
8. These states are discontinuous with finite
boundaries . They might be close , but not continuous .
9. This means that even small discontinuous
influences (the sound of a truck going by , somebody dropping a pencil ,
playing rock music , etc) will affect the outcome of the experiment . Just
compensate for them , like sound-cancellation . Well within our tech
capabilities .
10 . Applications of the humorous kind :
Barely failures :
10.1 Cold fusion :
Worked sometimes , sometimes not . Cancel outside
vibrations and vroom off .
10.2 Homeopathic medicine :
So close ! But so far !
The trick is in the succussion . https://www.youtube.com/watch?v=vMK_wLYKpF0
They ignored the only active element !
And that is the single element they did not
standardise .
The hidden assumption strikes again !
The baby is thrown out with the bathwater .
11.Industrial applications :
Well , the above discussion described chaotic
assembly of chemical compounds , which is used in a third of chemical
engineering .
The only difference is that more complex pressure
differentials are used .
12. Speeding things up .
From Appendix A , you will notice that most
mathematical analyses are done on 1/(r^2) basis , ie unconstrained pressure
wave . But in real life that never happens .
We constrain things by putting them in reaction
chambers and stirring the hell out of them .
A simple way is Psyllium Husks and Microwaves .
The constraints are random , but that just makes
it more interesting .
Many new compounds will be generated . (Hopefully
, none will kill you – Darwin)
If you want to go the homeopathic route , simply
take a drop , add psyllium , microwave , etc .
Note that you have the same problem with water as
mathematicians have with randomness .
Can you exclude meaning ?
Of course you can’t .
Meaning spontaneously assembles out of finite
random choices from an infinite smorgasbord .
13. Kitchen proof :
13.1 Coffee : 1 tsp instant coffee , ½ tsp
psyllium husks ,add water , mix well , wait 10 minutes , microwave .
It tastes like a high end coffee .
Many of the aromatics have been randomly recreated
in the psyllium reaction chambers .
13.2 Second Level coffee :
Take a ½ tsp of coffee from above para 13.1 ,
repeat . What does it taste like ?
I tried it . It tasted like very refined coffee .
The lighter aromatics .
I presume after a few more refinings it
will be fit only for angels , since only they could taste it .
14. Major applications :
14.1 Perfume . Create new perfumes . Revitalize
old ones .
Brew new potent sex pheromones in your kitchen !
(Beware of roach contamination)
14.2 Tastes .New tastes . Can’t wait to try this
on curry . Or any spice .
14.3 Antibiotics . Put new discoveries on
fast-forward . Kill them all!
15.Interesting things should be going on in
galactic water clouds near supernova’s .
Kilonovas might be stellar engineering .
Cloud intelligences are a real possibility .
Imagine if every waterdrop falling is smarter than
you . What a worldview !
Every teardrop contains your multiplicities .
Andre
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Appendix A
References for the faint of heart . Just ignore
them .
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