Kidney Repair 101
Andre Willers
30 Jun 2014
Synopsis:
We attempt to find factors that aid the body to repair
kidney damage .
This is not medical advice . Consult your doctor .
Discussion :
1.Kidneys can repair themselves . See Appendix 3 for one way
they do it .
2.The body uses Prostaglandins that are steered by
Chaperones to Receptor sites to signal and trigger various processes .
3.For kidneys , PG2 docking
to EP3 applies , mediated by cAMP and PKA
chaperones .
See Appendices 1,2 and 3
See . http://en.wikipedia.org/wiki/Protein_kinase_A
for PKA
cAMP is an ATP linked molecule (see http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphate
and http://andreswhy.blogspot.com/2010/01/atp-as-neurotransmitter.html
and
)
4.Other major organs affected by this signal are Lipids ,
Muscles ,Liver , Nervous System , Kidneys
Systems affected are sugars (diabetes) , neurotransmitters ,
especially dopamine(Parkinsons) , blood pressure(hypertension) , ulcers
(Rivenprost)
5. What to do :
Aid the body to do natural repair and regeneration until
more precise techniques are available .
6. Kidney Repair Aids .
6.1 First , Do no Harm .
Stop any prescription drugs that causes Renal failure .
Use https://www.rxisk.org/Default.aspx
for bias-free side-effects analysis of drugs .
Unfortunately , widely used bloodpressure , diabetic ,
cholesterol , gout and ACE blockers all are implicated in “Renal Failure Acute”
as a major side-effect .
6.2 Replace with friendlier alternatives , especially if
kidney damage is already present :
Eg gout or cholesterol (Pantothine) , diabetes(low-carb diet)
, ACE blockers (Rooibosch tea , aged Gouda cheese 8mths aged ,etc) , Calcium
blocker(ginger) , bloodpressure (Vit D , sesame oil)
Search on internet, test and monitor .
Revert to old drug on occasion if necessary .
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6.3 Helper Sequence (must be in this order)
6.3.1 Vit C 2000 mg
6.3.2 Sodium Bicarbonate (1 teaspoon) .This is to help
kidneys regulate ph of blood .See http://en.wikipedia.org/wiki/Base_excess
6.3.3 Eat some Jelly (Gelatine) . Major nutrient source ,
all nicely packaged. Add Wheat Grass .
6.3.4 Take Branched Chain Amino Acid supplements .(Leucine ,
Valine , Isoleucine) About 400 mg . This is for ATP formation .
6.3.5 Take Essential Fatty Acid supplements (EPA, DHA , ALA
, GLA) . About 800 mg .This is for kidney operation
6.3.6 Stimulate ATP production . This uses up Phosphor ,
which gives the kidneys a rest .The ATP is then also used as chaperones .
Exercise (aerobic , at least 5 minutes) or better , APS ATP-generator
: see http://www.apstherapy.com/ . Place electrodes over kidneys .
Hhhhhhhhhhhhhhhhhhhhhhhh
6.4 Control blood pressure .
BP after 2min exercise must be less than (Resting BP +16.1
x2 )
Eg , if Resting BP = 120 , then after 2 minutes exercise BP
should be less than 152.2
See Appendix 4 below for boundaries for strokes .
Note that kidney damage from high BP can be seen as a form of
stroke .
6.5 Sesame oil and Blood Pressure .
About 2 tablespoons of sesame oil per day should normalize
or reduce BP and triglycerides .
Take medical advice if taking BP medication .
6.6 Take the usual supplements .
6.7 Dandelion , horsetail and Green teas benefit the kidneys
.
6.8 Biofeedback .
Google it
6.9 Apps .
7. Give your kidney some help !
Andre
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Appendix 1.
http://en.wikipedia.org/wiki/Prostaglandin_receptor
Prostaglandin receptor
From Wikipedia, the free
encyclopedia
There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind
to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled
receptors.[1]
These receptors are named:
The names of these receptors correspond to the
prostaglandin that they bind (e.g., DP1-2 receptors bind
to PGD2).
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Appendix 2 .
·
PGE2:
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Appendix 3 .
The full paper about kidney repair is at
Prostaglandin E2 promotes cellular recovery from established nephrotoxic serum nephritis
in mice, prosurvival, and regenerative effects on glomerular cells
Summary :
“EP3 receptor has been identified as important in mediating
beneficial effects of PGE2 in
our system. PGE2 normalized
glomerular cell losses during nephrotoxic serum-induced nephritis, restored
synaptopodin distribution and F-actin filaments arrangement in glomeruli”
“ In conclusion, PGE2 treatment
promotes resolution of glomerular inflammation. Consistent with this
observation, the regenerative and cytoprotective effects of prostanoid on
glomerular cells in culture were observed, suggesting that PGE2 may be beneficial in
the treatment of glomerulonephritis.”
Methods to repair kidney cells, assess kidney
function on the horizon
Date:
April
16, 2013
Source:
Medical
College of Georgia at Georgia Regents University
Summary:
Researchers
may have found a way to block kidney-destroying inflammation and help damaged
kidney cells recover. In a related study, they report progress on a
non-invasive method to assess how much kidney function has survived a serious
bout of inflammation or a chronic problem like high blood pressure.
In
an effort to better protect them, researchers induced acute kidney
inflammation, or nephritis, in mice then gave them prostaglandin E2 . The
kidneys' filtering units promptly recovered. "The cells got better, the
kidneys got better," said Madaio, corresponding author of the study in
the American Journal of Physiology-Renal Physiology.
While
prostaglandins are better known as natural pro-inflammatory lipid compounds,
prostaglandin E2 has an anti-inflammatory effect. The researchers suspected --
and found -- it also had the bonus regenerative properties.
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Appendix 4 .
Systolic Blood Pressure (SBP) Response to
Exercise Stress Test and Risk of Stroke
Methods— SBP
was measured every 2 minutes during and after the exercise test. The subjects
were a population-based sample of 1026 men without clinical coronary heart
disease, antihypertensive medication, or prior stroke at baseline. During an
average follow-up of 10.4 years, there were 46 cases of stroke (38 ischemic
strokes).
Results— Men
with SBP rise >19.7 mm Hg per minute of exercise duration had a 2.3-fold
increased risk of any stroke and a 2.3-fold increased risk of ischemic stroke
compared with men whose SBP rise was <16 .1="" 2="" 4.6-fold="" 5.2-fold="" a="" after="" and="" any="" associated="" at="" by="" divided="" exercise="" hg="" highest="" increased="" ischemic="" maximum="" min.="" minutes="" mm="" o:p="" of="" percent="" recovery="" risk="" sbp="" similarly="" stroke.="" stroke="" tertile="" was="" with="">
Conclusions— SBP
rise during exercise and percent maximum SBP at 2 minutes after exercise were
directly and independently associated with the risk of all stroke and ischemic
stroke. Exercise SBP testing may be recommended as an additional tool in the
prediction of future stroke.
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Appendix 5 .
Effect of Sesame Oil on Diuretics or ß-blockers in the
Modulation of Blood Pressure, Anthropometry, Lipid Profile, and Redox Status
This article has been cited by other articles in PMC.
Abstract
The study was undertaken to investigate the effect of sesame oil in
hypertensive patients who were on antihypertensive therapy either with
diuretics (hydrochlorothiazide) or ß-blockers (atenolol). Thirty-two male and
18 female patients aged 35 to 60 years old were supplied sesame oil (Idhayam
gingelly oil) and instructed to use it as the only edible oil for 45 days.
Blood pressure, anthropometry, lipid profile, lipid peroxidation, and enzymic
and non-enzymic antioxidants were measured at baseline and after 45 days of
sesame oil substitution. Substitution of sesame oil brought down systolic and
diastolic blood pressure to normal. The same patients were asked to withdraw
sesame oil consumption for another 45 days, and the measurements were repeated
at the end of withdrawal period. Withdrawal of sesame oil substitution brought
back the initial blood pressure values. A significant reduction was noted in
body weight and body mass index (BMI) upon sesame oil substitution. No
significant alterations were observed in lipid profile except triglycerides.
Plasma levels of sodium reduced while potassium elevated upon the substitution
of sesame oil. Lipid peroxidation (thiobarbituric acid reactive substances
[TBARS]) decreased while the activities of superoxide dismutase (SOD), catalase
(CAT), and the levels of vitamin C, vitamin E, ß-carotene, and reduced
glutathione (GSH) were increased. The results suggested that sesame oil as
edible oil lowered blood pressure, decreased lipid peroxidation, and increased
antioxidant status in hypertensive patients.
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