Training the Immune

Training the Immune System.

The immune system is capable of handling most diseases , but is primarily reactive . The initiative is with diseases causing rapid changes in the targeting markers . Two new powerful techniques , which works very well in synergy , have emerged :

Method :
1. Isolate some disease causing cells (ie cancerous cells , HIV , etc)
2.Slow the activity in the cells , thereby halting cell-wall changes , by using H2S concentrations graduated from (say) 75 ppm to 80 ppm.
3. Kill the cells using hypochlorous acid ( bleach ) .

1. Inject the lot back into the organism  .


2. Repeat quickly.

Rationale :

1. The effect of H2S is well documented .
It slows the metabolism of the whole cell , including the cell-wall .

2. The effect of hypochlorous acid ( bleach ) :
Refer to
Cancer Immunology and Immunotherapy , Do1:10.007/s00262-006-0127—9
Or
New Scientist  of 4 March 2006 p17 .

Cancer cells killed by hypochlorous acid (HOCl) ( bleach ) is five times more likely to be recognized as malign by dendritic cells than those killed by other means . This is an experimental fact .
The reason seems to be that one of the main methods by which the immune systems
kills deviant cells is by an injection of hypochlorous acid ( bleach ) . The fragments of hypochlorous acid mark the fragments of target cells as enemies to the immune system .
It is interesting to note that this seems to indicate a rapidly changing cell-wall structure for cancer cells , as there is a enemy-recognition , but not a very big one . This suggests the changeable cell-wall frozen at the moment of death does not encompass a large variety of the surface-configurations the cell can assume .

Hence we suggest a H2S concentration gradient up to stasis level to halt the various cell-wall permutations at various configurations at the moment of the hypochlorous acid kill . This should increase the immune system’s  enemy recognition percentage .

The question remains why would the technique be more effective with H2S than without it ?
The answer is that these intractable diseases , by definition , has evolved anti-attack mechanisms . One of these would certainly involve rapid change in the surfaces of the cells . The cells in the treatment sample would quickly diverge from the body’s system  . The body’s system would change slower because of signaling molecules (refer to quorum effect ) .
Thus , by immediately slowing the treatment sample by a graduated H2S concentration , killing it and immediately re-injecting , the immune system gains recognition of the enemy and hopefully some degree of advance on it .

The suspicion arises that a very simple molecule like HOCl is like other similarly simple molecules (nitrogen oxides , CO2 , etc that are used by living organisms as powerful signalling molecules .

HOCl kills any cell we know of . The only defense seems to be a thick shield . Is this wholly due to it’s reactive nature , or is there also a receptor site for it ? Immune cells kill by injecting it through a synapse-like structure . Thus , the targeting mechanism and the lethal payload share a linkage . This structure can learn through evolution .

Evolutionary speaking , the immune system will first try to kill by apoptosis as this is more economical . If this fails , then it will try to kill the cell by HOCl injection . If this fails and the system is still under stress , the chances are that it is a disease that is changing cell-walls quicker than the matching changes in the synapse-like immune cells mechanism .

The immune system will evolve two strategies :
First , try to decrease the change-speed in the attacking organism (first because this is older in evolutionary terms .)
Then , increase the learning speed of the immune system . Can you see where this is heading ?

Strategy 1 . Decrease in the change-speed in the attacking organism (whether internal like cancer  or external like flu ) is handled by H2S type mechanisms . Hence the importance of sulfur ( see my previous notes ).

Strategy 2 . Increase the immune system’s learning speed.
Erk. This is a bit humbling .
On a basic level , Iodine seems to fill the requisite niche for a simple thing that has profound effects on the immune system , and thus on the nervous system .

The mechanism controlling the long-term , planet-wide distribution of sulfur and iodine is the algal organisms in the upper levels of the oceans . These are very temperature-dependant .

As the planetary temperature rises , the average concentration of sulfur and iodine falls because the algae retreat to the poles . Diseases increase . The immune systems first try the H2S route (because this is older ) , then try increasing the learning speed . We see this as intelligence .

Thus , we can see the pulse of intelligence in human affairs after the end of the last ice-age as a direct result of the increase in diseases caused by the decrease in sulfur and iodine concentrations .

An example: It is generally thought that the increased fishing off African waters caused the Africans to eat more bush-meat , thereby increasing their exposure to exotic diseases . But they have been eating the same for thousands of years . The critical lack is iodine

To sum up , human increased intelligence can be seen as an immune-system response to periods of warm inter-glacials . Since there is small evolutionary pressure to decrease intelligence , the effect ratcheted up . At present , humans can be seen as part of the planetary response to the relentless warming of the sun .

In other words , a planet like Earth which started off slightly too cool about 3 billion years ago , reached ideal life-temperature about 2 billion years ago and has gradually heated up as the sun became hotter (it is now 25% hotter than 3 billion years ago) .

The life-systems on the planet formed a complex feedback system which kept the system at livable temperatures . (Cf  Daisyworld , Gaia  and similar models) .

It is important to realize that the insolation from the sun fluctuated . The higher influx from sol left less leeway on the upper end of the boundary for living organisms on earth . A bit hotter , and living things did not as well with as a bit cooler .

So , as the sun became hotter , the earth’s thermostat evolved to be cooler (to leave room for fluctuations on the hot side). Please note that no conscious agency is necessary . Living learning mechanisms like discussed above evolved and became more intelligent with each heat-burp .

Till eventually , we get the present situation . Humans will have to cool the planet or become extinct . This can be seen to be (nearly) inevitable from the first planetary configuration . Another way of looking at it that humans are a part of the life systems on the planet ensuring its continuation .

Humans are a result of the heating of the planet , not the cause .

Intelligence is inevitable on any planet around a star on the main sequence .

Andre

Primitives_0

Primitives _0

http://andreswhy.blogspot.com 
 
Dated 7/06/2006
 
Quantity has a quality of its own (Stalin)

Background:

An example illustrates  :
The visual system works well by having multiple small , very rapid recognition centers that recognise edges , corners , curves , etc . These are then assembled into further complex images further up the line to the brain .

A single neuron one or two layers away from this first primitive can handle surprisingly sophisticated pattern recognition ( eg bees trained to recognise human faces , only one neuron activating on fMRI scan on recognising a face)

The Advantages:

1. Speed . This is all-important in a survival driven organism .

It is more important to have a 80% picture of the environment in half a second than a 98% picture in 2 seconds . By moving the eye , the recognition system is also tweaked . In other words , you get as good or even better picture of the environment by the assembly of rapid exposures at a lower definition at different viewpoints than a long exposure at a single viewpoint .

Note that the latest findings indicate that the only difference between animals and humans is the speed and capacity at which we perform tasks like planning , memory , tool usage , etc .

Also note that there is a fundamental correlation on neural-network level between speed and capacity . ( Hence the time-constraints in exams , IQ tests , sports ,ets)

1. Reduction in complexity . You need fewer neurons to do the same task . Most of the number of input data are used in the first primitive layer , which is usually hardwired (ie retina) to be very fast . The subsequent neural-network layers need orders of magnitude fewer nodes . The assembly over time of different viewpoints in these primitive snapshots ( ie the differences) will pick up the elements missing in each snapshot due to poor resolution .

Since we know that the minimum necessary sufficient number of dimensions in an Euclidean space is three , we can say that any visual system would work which has three layers . The more data is processed in each succeeding layer , the better , as long as there is a time-difference between viewpoints .





The Disadvantage
 
Definition :
A system lacking a primitive needed to recognise a new factor in the environment might not pick it up . Most primitives are learned in very early childhood and fixated by paring of neural connections on a hardware level . Eg Chinese “r” and “l” problems .

In other words , it is difficult for an adult to learn new languages , accents or to correct faulty visual systems .

Examples of Human Primitives:

Existing primitives:
1.Visual ( Retina-brain)

• Pattern recognition (lines , edges curves,etc)


• Peripheral movement (snapshot differences )


• Linear Trajectory (integration of eye and body movement in snapshot differences. Very high speed required . ) This is the ur time-binding primitive . How the past and the projected future connect .

This ability would normally evolve into intelligent planning capability if there is sufficient number of neurons . Birds were first , but are constrained by a terrible evolutionary trap : in a low density atmosphere like Earth , their maximum weight ,and hence cranial capacity , is limited . They have a ceiling . If they go flightless , without hands they will lose the trajectory primitive , since the ability to compute trajectories will have no survival value . They optimise (like smart crows ) , but generalization is constrained by cranial size .

Start Speculation
The KT impact would have made no difference in Terran civilization , except that the civilized species would have descended from tree-dwelling dinosaurs . (See argument about insolation fibrillations and Gaia driving intelligence development. ) . Alien intelligent avians would possible if the atmospheric density is high enough to support birds with big brains . An estimate would be 6 to 8 times Terran densities at the moment . A planet like Venus would always have a denser atmosphere ( no large moon) . If there is life in a solar system , it would be seeded on all the planets by meteor impacts . Hence we can speculate that intelligent life on Venus evolved first from an avian base . Since the insolation fibrillations would have hit Venus first (because of its thicker atmosphere) , intelligence would have evolved there first in the solar system . Estimated time about 600 – 1000 million years before present . So where are they now ?
They are either extinct (most likely) , or the planet-bound ones are on Saturn . The clouds of Saturn would be very attractive to an avian species .
End Speculation


Apes coming out of the trees already had hands that could throw projectiles and had to have the trajectory primitive .

Hence , the evolution of upright stance ( to keep the hands free for throwing stones ) and stone using ( leading to neolithic technology ) came first and then led to further time-binding developments like planning , language and intelligence .

Notice that any human society , present and historical , spent an inordinate percentage of resources on trajectory games ( basically ball games) . It is pure Darwinnian statistics : good ballplayers have better time-binding primitives and are better at estimating future effects .

A good ball-player is not more successful because he is a team-player . He is a better team-player because he binds time better  . Competition within co-operative boundaries .

Arrghh!

See Itarin for the nerd’s revenge .

2.Language : the primitives ( Broca’s area) are well established .
3.Fairness : Hardwired even into monkeys .
4.Math : count to 3 , rapidly and iteratively .
5.Threat avoidance : Hippocampus (Stress syndromes)
6.Balance (walking . ref vibrating soles.)
7.Creativity (not just LH/RH brain : it is a true primitive)
8.Music (inherent)
9.Risk/Reward : Profit . Making money (there has been heavy selection for this since the invention of agriculture ( ie surpluses)
10.Shapes (female hip , breast .Male buttocks , legs)
11. Pheromones
12. Immune system.
13. Religion

I’m sure there are more , but we know that these true primitives . Small , fast  , multiple (mostly hardwired) data-handling nodes feeding into more sophisticated feedback systems.

2. Primitives we would like to have .

A wish list.
Note that we might have the sensors for the desired characteristic , but not the primitive . The primitive would only evolve if there was an evolutionary pressure for it .

• Spin

Computing the flight of a ball due to aerodynamic factors . Trainable (See Itarin)

• Controlling the potentiating of hippocampus , immune system or any other primitive . A meta-primitive .


• Recognising and controlling quantum events .


• Recognising and controlling disequilibrium events


• Recognise and predict chaotic attractors.


• Sense and manipulate magnetic fields .


• Sense and manipulate nuclear fields .


• Sense and manipulate gravitational fields .

The general principle is that , if a primitive has not evolved , it can be created by using some existing structure and building on that .

Andre

-------------------------------------

Neuropathy

Diabetic Peripheral Neuropathy and Acrylamide

http://andreswhy.blogspot.com 
 
Dated 11/06/2006
 
Background:

See links at the bottom .

Acrylamide is formed by the Maillard reaction , when the Amino Acid Asparigine reacts with reducing sugars like glucose and fructose at a temperature over 120 degrees Celsius . (ie when bread , potatoes , cookies , etc begin to brown ).

Asparigine + glucose/fructose + (temp>120 Celsius) = Acrylamide

Acrylamide is a potent neurotoxin . It interferes with the internal neuronal transport in the axon . The transport of nutrients from axon nucleus to the end point of the nerve and the return of breakdown products of long nerves ( like to fingers and toes ) are first affected . The ends of the axon start to die . ( Numbness in extremities . )

Sensations of restlessness , tingling , burning , etc associated with peripheral neuropathy are probably caused by the spurious signals caused by the accumulation of debris at the interference site in the charge balance of the axon wall .
( Think train derailment in the middle of the Karoo , with the smashed up carriages messing up the signalling system )

Since many non-diabetics have peripheral neuropathy , the two diseases do not seem to be directly linked . But a synergistic link is strongly suspected .

But if you are diabetic and already have had attacks of peripheral neuropathy , ingesting high concentrations of acrylamide will surely lead to an attack of peripheral neuropathy .

Note the short half-life of acrylamide means that the concentration of acrylamide is driven by diet alone .

Asparigine , glucose/fructose , (temp>120 Celsius) are all three necessary to produce Acrylamide . Hence foods low on the first two , or cooked below 120 Celsius are safe .

The EU study found that 90% of diet derived acrylamide comes from :

French Fries (slap chips)  :  16% – 30%
Potato crisps  : 6% - 46%
Coffee (its always roasted ) : 13% -  39%
Pastries and Sweet biscuits : 10% - 20%
Bread , breadrolls , pizza and toast (especially the crust) : 10% - 30%

In general , avoid anything that used a temperature of 120 Celsius or above in it’s preparation . This includes teas .The effective concentrations of acrylamide needed to trigger the reaction is very low , especially for diabetics already sensitized .

Anything low GI microwaved submerged in water , or cooked without burning or browning should be ok .

Durum pastas should be ok , but no grills or ovens . Bye-bye toasted cheese sandwiches .

Bread.
If you have to eat bread , cut off the crusts . Mothers used to do this for their children .

Any connection to attention Deficit Disorder ?

The irritability felt in the first stages of peripheral neuropathy ( ie wandering feet , can’t keep still ) and later on , irritable aggressiveness , sleeplessness and any activity to focus attention on anything except the painful feet ) sounds like the recipe for aggressive expansion .

Remember , that only the upper and middle classes ate bread . The bottom class (99 % of the population till about 1800 AD) ate porridge morning , noon and night. Milling kernels of wheat was ( and is ) expensive in real energy terms . (cf “Roman women will not grind wheat or cook “ after the Sabine episode , or lack of white bread in WW2) . Since it is a high energy food , it would be one of the great ironies of history that Empires and Inventions were caused by bread crusts  .  There is also a positive feedback element involved , namely that the type of wheat with the highest aspargine content will be the most widespread ( spread by the restless conquerors ) .

One wonders if the political instability inherent in the Middle East and North Africa are due to the high acrylamide content of their traditionally baked (from hot rock flat bread) foods . (In poorer regions like Europe , the plebs could not afford the energy cost .)

Hah! So much for meat . The weevilly baked biscuit of the middle ages was the driving force of the mariners to populate the earth with high-asparigine wheat .

No wonder things have gotten more unstable . For every diabetic , there are at least ten with an itchy , irritable nervosity .

Will humans use aspariginase ? This is an enzyme that destroys asparigine . Dosing food to a country with this will render them relatively docile in long run . Any volunteers ?

An interesting corollary is rice vs wheat . Rice is usually cooked at 100 Celsius . As the Chinese and Indian populations shift to high-arganine western wheat types , not only will their diabetes rates rise , but their aggression will rise at a much higher rate .

Interesting times for all .


Can one bake bread at less than 120 Celsius ?



See web references on Acrylamide:

1. PIM’s (1999) : The clinical picture .
http://www.inchem.org/documents/pims/chemical/pim652.htm

Some highlights:

Chronic exposure to Acrylamide:
    
            Chronic acrylamide toxicity is characterized by local
            dermatitis, excessive sweating, fatigue, weight loss and
features of progressive CNS disturbance (especially truncal ataxia) and peripheral neuropathy.  The severity of symptoms and the rapidity of onset appears to relate to the duration of exposure to, and the daily dose of, acrylamide.  
Recovery over a period of weeks to months following removal from exposure is the usual course.

     Biological half-life by route of exposure

             In blood, acrylamide has a half-life of approximately 2
             hours. In tissues, total acrylamide (parent compound an
metabolites) exhibits biphasic elimination with an   initial
half-life of approximately 5 hours and a terminal half life of 8 days (Edwards, 1975; Miller et al., 1982).
Acrylamide does not accumulate in the body.  [Note: all data derived from animal studies].


2. On 25 April 2002 (cf New Scientist of 22 April 2006 p 8 ) , Sweden’s National Food Administration announced that acrylamide in significant concentrations was found in many common processed foods . This prompted a major clinical food study by the European Union : the results are given on the EU’s food site:
http://www.ciaa.be click on  Documents , Positions , search on acrylamides from website .

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Birdflu Survival Up

Birdflu Survival  Update –8

http://andreswhy.blogspot.com 
 
Dated 26/05/2006
 
On Your Marks!
 
The race is about to go to the starting blocks .

At the end below is a report which seems to indicate that human-human transmission has chained .

In previous human-human transmission cases , the transmission was :

Chicken -> human(1) -> many humans in contact with human(1) only .
The virus could easily be contained . Quarantine is very effective .

However , in this case the transmission was :
Chicken -> human(1) -> human(2) -> human(3) -> ? .

The virus according to report has not mutated . How can they know ? There has been no time for a full gene-sequencing . So they only looked at some markers .

This raises the spectre of Priming .

Priming .
In general :
Lethality remains switched off until triggered by the environment .
It must be emphasized that is a dynamic process driven purely by evolution .

Background:
The body contains many potentially lethal biosystems (call them the Pirates) whose predations are kept in check by the body’s counter  system (call it the Navy ) . Then there are also the legitimate activities ( call them the Merchants).

Evolution :
Merchants would be the first , with Pirates an extremely close second . The Navy would have evolved after mitochondria ( which would be Pirates turned into Merchants by symbiosis with Mitochondria .) The Merchants with Mitochondria can now afford to hire privateers (former Pirates ) . They pay them with energy and convert them into Navy .
This makes multi-cellular organisms possible .


Combinations possible:
Navy – Navy  ( Body attacks its own immune system)
Navy – Pirates (The intended function)
Navy – Merchant ( Autoimmune , etc)

Pirate – Pirate ( the baddies zap each other , privateers bribed by Merchants)
Pirate – Navy ( overwhelming , infiltrating or undermining the immune system)
Pirate – Merchant (the originating robbery :diseases)

Merchant – Merchant ( normal competition within an co-operative network)
Merchant – Pirate (bribing Pirates and converting them to privateers and then Navy)
Merchant – Navy ( paying Navy with goods , energy and information)

Flags of Convenience.
Many Pirates fly flags of convenience , and as long as they do no harm , the Navy tolerates them .

If the Navy tries to board everyone , they quickly run out of resources . They can only afford to check the known Pirates . In our polluted environment , the number of chemicals unknown to the Navy is increasingly very rapidly . An intriguing speculation is that some metabolic abnormalities like Diabetes  is an attempt by the Navy to get more resources , but hobbled by some bottleneck in resources .

Look at the super-immune systems :
Crocodiles and sharks . Crocs are the best .
The croc can hibernate : H2S mechanism . This must perfuse the whole system to be effective . Once it is switched off , the whole immune system (and selected metabolic systems) has to go into overdrive to get enough energy to the immune system to fuel the identification and blocking of any chemical . Remember , that crocs have been doing this for about 200 million years . Asteroid impacts are ho-hum . Acidification of the ocean ? Just bubble it through your teeth for Coke . Hot , cold ,dry wet ,etc

But they evolved it quite early , so the last couple of hundred million years do not count , except to show that it freezes gene , epigenetic , retro-virus and cultural systems . Mutation as well . Notice that the present croc is very similar to the one 200 MY ago . This is nearly inconceivable , except for there it is .

The only similarity in the surviving crocs is their environment : alteration between oxygen-rich and oxygen-poor .(Up and down in the water) Not much promise .

But crocs are equivalent to live-birth sharks and mammals , only slightly better : the eggs and the live young are carried in their mouths for a significant period of time . The decaying meat between its teeth generates enough H2S to kick in suspended animation in the small fry . The biggie will probably have evolved (albeit slowly) to be very sensitive to low concentrations of H2S .

The decay also generates methane (CH4) . It stashes its prey underwater , where anaerobic rotting produces more CH4 than H2S . Remember that the beastie’s mechanisms are 200 MY old and must have evolved in an oxygen rich atmosphere .

Basically , it means that something in the crocs mouth causes an epigenetic-like effect on its offspring .



What can it be ?
It must be a simple chemical . (Old). To be a signal , it must not be common . (Shannon) It must really speed up the metabolism in the same concentrations as H2S (as they evolved at the same time) .
Oxygen-type metabolisms must be switched on without upper boundaries : like what one would expect in the ur-methane atmosphere . In other words , the presence of methane stimulated ur-bacteria to utmost metabolic activity to make oxygen (standard evolutionary theory ) .The oxygen metabolism is then at max without stoppers .

Methane (CH4) springs to mind .

Crocs and sharks use a whipsaw effect between H2S and CH4 to freeze any change
( and be effectively immortal . The price is no evolution)
It only works for a multicellular organism:

How it works :
It is a cycle effect .
H2S reduces the metabolism quickly to very low levels.
CH4 supercharges the metabolism , out of the frozen state , but not all at once , since it thaws in layers . The highly energetic layers are templated on the H2S-frozen templates in the DNA and Epigenetic processes .

It is like remembering something by repeating it continuously.
The error rate is zero as long as the message is less or equal to the short-term memory.
In genetic terms , the short-term memory is the genome and epigenetic terms bound to it . But not Cultural systems.


Awesome .


The moment the Navy shows weakness or the Pirates count noses and sense that they have to attack immediately to share in the spoils (the tragedy of commons ) , they hoist the Jolly Roger and haul out the cannons .
Many Merchants might even join in .

But all Pirate captains are not equal . Some are much , much worse than others . The really evil captains’ progeny spread in a statistical fashion . The plague ones who are only one mutational jump away from lethality will display superior multiplying and spreading ability (otherwise they will not be plagues) . They will also think similarly and react similarly to the triggering situations .
They will be all over , spread by the mobility inherent in the Civilization of Cells or Nations .

This is known as Priming .

At some point , local conditions cause the last fateful mutation . The same conditions are likely to be repeated in the ambit of the contact sphere . The same mutation results in a statistically significant number of lethality  cases , as well as contagious triggering .

The resulting pandemic seems to arise from multiple sources ,  It is like a kettle coming to boil . Some bubbles do start others , but many are just from random , chaotic stimuli triggering the lethality .

Unfortunately , pandemics like these seems to be a logical consequence of connectivity (ie mobility of gene or meme markers ).

This is independent of whether the information is in genes or memes .

In other words , a lot of mobility like an Empire or Globalization will inevitably mean a plague , either bacterial/viral or meme. (Like Nazism , communism ,etc)

What to do :
Alternating (80 ppm H2S) with ( 80 ppm CH4 + mega sugar + multimineral + multivitamin ) should at least halt aging .

Stem cell effects:
The same regime effects limb regeneration in crocs and sharks .
So , getting younger is not impossible .

Eternal Youth !

Yours

Andre Willers




 --------------------------------------------------------------------------------------------

The Report. 


Bird flu team 'too late' for answers
Clara Pirani, Medical reporter
May 26, 2006
DELAYS in the investigation of the world's largest outbreak of bird flu may prevent health officials from ever knowing if human-to-human transmission of the disease killed six members of the same family in Indonesia.
A team of the world's leading avian flu experts has arrived in the remote village of Kubu Sembelang in North Sumatra to investigate the deaths, which occurred during the past three weeks.
However, the director of the World Health Organisation's Collaborating Centre for Reference and Research on Influenza in Melbourne, Ian Gust, said most of the evidence would already have been destroyed.
"We've found with the investigation of clusters in the past that by the time the investigators get there, it's too late," he said yesterday. "Any infected birds that might have been around have gone or been killed.
"You can't take the adequate samples and you'll never know the cause, and that's a problem."
Indonesian health officials were not responding quickly enough to potential cases of the disease, Dr Gust told The Australian.
"Indonesia is still struggling with it. Vietnam, which had a very serious problem with bird flu, has essentially brought it under control by very vigorous health measures, whereas Indonesia is still getting lots of outbreaks in birds and lots of cases in humans," Dr Gust said.
Vietnam reported 61 cases of bird flu last year, including 19 deaths - significantly more than any other country.
Twenty-two people have died of bird flu in Indonesia this year while Vietnam has experienced no new cases.
Peter Cordingley, spokesman for the WHO's West Pacific region, said investigators were concerned about the cluster of deaths in North Sumatra - the largest to date - and the source of the outbreak.
He said they had not found any infected poultry in the village.
"When we can't find a common outside source, we have to look at the potential for human-to-human transmission," he said.
Infected poultry has been the source of the majority of human infections worldwide. However, the WHO suspects human-to-human transmission may have caused up to half a dozen previous clusters in recent years.
Mr Cordingley said there was no effective test to confirm human-to-human transmission.
"We've had very strong evidence of human-to-human transmission before, but in the end we haven't been able to draw any further conclusions, so we just don't know," he said.
Seven members of the same family in North Sumatra contracted the disease and six have died in the past three weeks.
An eighth family member, the first to become ill, died on May 4, but no samples were taken to confirm the cause of death.
Two of the men who died spent the night of April 29 in a small room with their mother - the first family member to fall ill - who was reportedly coughing frequently. A third son has the disease and is the sole surviving family member.
Another family member, a 32-year-old father, died on Monday after caring for his sick son.
Other infected family members lived in adjacent homes.
The H5N1 virus has killed 124 people since 2003 and more than 30 countries have reported outbreaks in poultry or wild birds.
The WHO has previously warned that clusters of the disease are considerably more dangerous than isolated infections because they raise the possibility that the virus might have mutated, allowing it to spread rapidly among humans, and sparking a pandemic that could kill millions of people.
However, Mr Cordingley said there was no evidence of spread within the general community with the latest cluster.
"Nobody outside the family shows any sign of infection, so we don't have a virus on the run," he said. "The virus samples from those who died shows the virus is not mutating and it shows no new ability to mutate from chickens to humans."
-----------------------------------------------------------------------

Orion Gaia Needs Yo

Orion , Gaia Needs You !
http://andreswhy.blogspot.com
Deep background:

Gaia

Gaia is the shorthand for the feedback system whereby the living organisms on planet Earth maintain the planet’s temperature within livable ranges . The increasing insolation output from Sol ( up 25% over the last three billion years ) is pushing the adaptability envelope (Cf Lovelock).

The fibrillations  in climate at the extremes of adaptation give rise to intelligence . Intelligence can thus be seen as an inevitable consequence of a main sequence star of Sol’s mass reaching a certain age . This has two interesting corollaries:

1. Putative civilizations in the local stellar group will be of about the same level .

Note that only the increasing temperature of the Sol-type sun is a factor . Asteroid impacts , etc are immaterial . Any present contacts with local civilizations will be at about the same intelligence level . Technology levels can be measured in the log of energy utilization . In other words , the gap between nuclear-energy using civilizations cannot be as large as , say between Europeans and Amerindians/Africans in SolTerra’s history . Also , note the successful assimilation of higher technology in Russia , China , India , Japan . The key seems to prevent a massive depopulation due to plagues .

1. Intelligence can be seen as another way in which the feedback mechanism operates . Humans will have to manage the planet more pro-actively to ensure their own survival . This enevitably means the survival of the ecosphere . Shading the planet , moving off-planet to habitats , terraforming Mars, Venus et al , or colonizing other solar systems are ways of doing this .


2. Exclusion ! The one response guaranteed to lead to extinction is “Business as usual” .  The planetary system is nearing the limits of it’s adaptive capability . The evolution of intelligence is a symptom of this . Supra-planetary intervention is needed .


3. For that , the ability to use and get large masses ( ie in the millions of tons ) into orbit is necessary .

Orion

See excellent Wikkipedia summation .     en.wikipedia.org/wiki/Project_Orion

Deep background:

Any explosive reaction propulsion system is essentially like exploding a cracker  in the middle of kettle . If you leave a hole in one end of the kettle , you have a rocket or a jet engine with thrust in the direction opposite to the hole . But Newton’s laws says that no matter how fancy your tricks , the force-components at ninety-degrees to the thrust direction cannot be used for propulsion .

Propulsion and lift .
Yet nearly all our present aircrafts’ propulsion is on the horizontal (propellers or jets) . The vertical lift is by air-pressure differentials on special surfaces (wings) .

Our problem is not a gravity-well . If it was not for the atmosphere , we could simply build a long rail-gun to get any desired mass into orbit .

1 . The Original Orion :
A buffered plate with energetic series of explosions under it (nuclear if necessary ) . All lift given by propulsion . Maximum possible efficiency 50% .

2. Orion Air-Lift
The explosion is above the plate .We do not contain the sides of the explosion . The shock-wave sweeps away the air above the plate . The air-pressure differential lifts the whole contraption .
We already know that we require far less force to get aero-dynamic lift than straight-up vertical propulsion . ( Go to any airport) .

This is essentially an inverted hovercraft . The difference  is that the pressure is removed from the top of the plate in a series of pulsed explosions . Since the explosions need not be contained ( like in a jet engine) , conventional , shaped or nuclear explosives can be used . Anything with a bit of vooma .

The plate can be anything durable (concrete , granite ) . The lift is like a hovercraft : the larger the surface area , the better . 10 000 to 100 000 tons seems to be good estimates to put into orbit using conventional explosives like semtex . See tweaking .

Tweaking:
2.1 Put a hole in the center of the plate , with a cap on top .  Vertical component of thrust is added .
2.2 Fresnel type effects are possible .
2.3 The contraption will have to start falling sideways at higher altitudes . Secondary shuttles can use it for orbital launch . The whole plate can go standard Orion or Railgun Orion to go into orbit .

Orion Rail-Cannon.

For those who need to zap an incoming asteroid , missiles , or in extremis , an incoming comet .

This is a purely destructive hypervelocity bullet that can be fired from the surface of the planet with little preparation necessary . A desperation tool .

Essentially , we have to drill a tunnel of vacuum in the atmosphere for our bullet , while erecting an electromagnetic-railgun to accellarate it to a reasonable fraction of lightspeed .

The method:
Have a plate with a hole in the center . Have a wire-tube of ionized air paths (laser guides from orbit or from plate ) .

Explode pulsed nukes below the hole in the plate .

The blast through the hole blows ionized air and ablatives through the laser ionized air-paths , inducing huge currents . The currents act as a linear rail-gun . It also blows a vacuum ahead of the plate .

Repeat the pulse .

What makes it cheap , easy and quick at present is that the nuclear pulse can be delivered from outside the tube (ie cruise missiles)

Ten square miles of Canadian shield rock 3000 feet deep can be converted into a pulse of plasma moving at about 0.1 c using about 100 cruise missiles . Of course , in such a case , the atmosphere ahead of the projectile will have to blown away as well .

Do not try this at home unless you have no choice !

It will make a really ,really loud bang ! The planet will go boing! . The night-sky will be like day .

Planetary temperatures will fall , due to small particulates  degrading into the atmosphere . But this is only a short-term solution to increased Solar temperature .

A least-intervention solution is to gradually shift the Earth’s orbit outward . This is easily within present technology ( cf studies) . A series of asteroids or comets steered close to Luna when it is farthest from the sun will tug the Earth-Luna system into a wider orbit using only gravitational forces .  (Jupiter has already done this) Mining the Sun for energy will also quickly soak up the extra energy . All dependant on massive extra-Terra activity .



The singularity.

This is essentially a deus-ex-machina argument . Everybody  (or a significant fraction ) will become like gods and fix all the problems . The teensy problem is that most humans of first-world countries are already like “gods” , in terms of previous civilizations . They fly , see distantly , hear the dead , kill at the touch of a button , etc, etc . Extrapolate this forward . The hope is that there is a phase change . But the only phase change we know of on a reliable basis is Death .

But death is not what it used to be . In SF you have personality downloads . If your collection of photos and textmemories cobbled together by a AI passes the Turing test , is the person dead ? Half dead ? 80% dead ?

Can you see the problem ?

We thought there would be neat division : an event horizon . But in real life , the dead hang around long after they should have decently buggered off . And the more they are with us , the more we need to be purged . Their dead hands hang around in photos , patents , trademarks , statues ,plays , music ,novels , until a violent convulsion is needed to get rid of the past .

Weltschmertz while looking at old photographs should be firmly stamped on .
This is why Napoleon was known as the Great Disturber .

This convulsion is usually given the name of a revolution , or singularity .

So the singularity is always with us , but only more so if you are dead .

Hah! My quote!
A suitable revenge is to remember only the good parts .

Andre

Training the Immune

Training the Immune System.

The immune system is capable of handling most diseases , but is primarily reactive . The initiative is with diseases causing rapid changes in the targeting markers . Two new powerful techniques , which works very well in synergy , have emerged :

Method :
1. Isolate some disease causing cells (ie cancerous cells , HIV , etc)
2.Slow the activity in the cells , thereby halting cell-wall changes , by using H2S concentrations graduated from (say) 75 ppm to 80 ppm.
3. Kill the cells using hypochlorous acid ( bleach ) .

1. Inject the lot back into the organism  .


2. Repeat quickly.

Rationale :

1. The effect of H2S is well documented .
It slows the metabolism of the whole cell , including the cell-wall .

2. The effect of hypochlorous acid ( bleach ) :
Refer to
Cancer Immunology and Immunotherapy , Do1:10.007/s00262-006-0127—9
Or
New Scientist  of 4 March 2006 p17 .

Cancer cells killed by hypochlorous acid (HOCl) ( bleach ) is five times more likely to be recognized as malign by dendritic cells than those killed by other means . This is an experimental fact .
The reason seems to be that one of the main methods by which the immune systems
kills deviant cells is by an injection of hypochlorous acid ( bleach ) . The fragments of hypochlorous acid mark the fragments of target cells as enemies to the immune system .
It is interesting to note that this seems to indicate a rapidly changing cell-wall structure for cancer cells , as there is a enemy-recognition , but not a very big one . This suggests the changeable cell-wall frozen at the moment of death does not encompass a large variety of the surface-configurations the cell can assume .

Hence we suggest a H2S concentration gradient up to stasis level to halt the various cell-wall permutations at various configurations at the moment of the hypochlorous acid kill . This should increase the immune system’s  enemy recognition percentage .

The question remains why would the technique be more effective with H2S than without it ?
The answer is that these intractable diseases , by definition , has evolved anti-attack mechanisms . One of these would certainly involve rapid change in the surfaces of the cells . The cells in the treatment sample would quickly diverge from the body’s system  . The body’s system would change slower because of signaling molecules (refer to quorum effect ) .
Thus , by immediately slowing the treatment sample by a graduated H2S concentration , killing it and immediately re-injecting , the immune system gains recognition of the enemy and hopefully some degree of advance on it .

The suspicion arises that a very simple molecule like HOCl is like other similarly simple molecules (nitrogen oxides , CO2 , etc that are used by living organisms as powerful signalling molecules .

HOCl kills any cell we know of . The only defense seems to be a thick shield . Is this wholly due to it’s reactive nature , or is there also a receptor site for it ? Immune cells kill by injecting it through a synapse-like structure . Thus , the targeting mechanism and the lethal payload share a linkage . This structure can learn through evolution .

Evolutionary speaking , the immune system will first try to kill by apoptosis as this is more economical . If this fails , then it will try to kill the cell by HOCl injection . If this fails and the system is still under stress , the chances are that it is a disease that is changing cell-walls quicker than the matching changes in the synapse-like immune cells mechanism .

The immune system will evolve two strategies :
First , try to decrease the change-speed in the attacking organism (first because this is older in evolutionary terms .)
Then , increase the learning speed of the immune system . Can you see where this is heading ?

Strategy 1 . Decrease in the change-speed in the attacking organism (whether internal like cancer  or external like flu ) is handled by H2S type mechanisms . Hence the importance of sulfur ( see my previous notes ).

Strategy 2 . Increase the immune system’s learning speed.
Erk. This is a bit humbling .
On a basic level , Iodine seems to fill the requisite niche for a simple thing that has profound effects on the immune system , and thus on the nervous system .

The mechanism controlling the long-term , planet-wide distribution of sulfur and iodine is the algal organisms in the upper levels of the oceans . These are very temperature-dependant .

As the planetary temperature rises , the average concentration of sulfur and iodine falls because the algae retreat to the poles . Diseases increase . The immune systems first try the H2S route (because this is older ) , then try increasing the learning speed . We see this as intelligence .

Thus , we can see the pulse of intelligence in human affairs after the end of the last ice-age as a direct result of the increase in diseases caused by the decrease in sulfur and iodine concentrations .

An example: It is generally thought that the increased fishing off African waters caused the Africans to eat more bush-meat , thereby increasing their exposure to exotic diseases . But they have been eating the same for thousands of years . The critical lack is iodine

To sum up , human increased intelligence can be seen as an immune-system response to periods of warm inter-glacials . Since there is small evolutionary pressure to decrease intelligence , the effect ratcheted up . At present , humans can be seen as part of the planetary response to the relentless warming of the sun .

In other words , a planet like Earth which started off slightly too cool about 3 billion years ago , reached ideal life-temperature about 2 billion years ago and has gradually heated up as the sun became hotter (it is now 25% hotter than 3 billion years ago) .

The life-systems on the planet formed a complex feedback system which kept the system at livable temperatures . (Cf  Daisyworld , Gaia  and similar models) .

It is important to realize that the insolation from the sun fluctuated . The higher influx from sol left less leeway on the upper end of the boundary for living organisms on earth . A bit hotter , and living things did not as well with as a bit cooler .

So , as the sun became hotter , the earth’s thermostat evolved to be cooler (to leave room for fluctuations on the hot side). Please note that no conscious agency is necessary . Living learning mechanisms like discussed above evolved and became more intelligent with each heat-burp .

Till eventually , we get the present situation . Humans will have to cool the planet or become extinct . This can be seen to be (nearly) inevitable from the first planetary configuration . Another way of looking at it that humans are a part of the life systems on the planet ensuring its continuation .

Humans are a result of the heating of the planet , not the cause .

Intelligence is inevitable on any planet around a star on the main sequence .

Andre

Mouse Rage Road Rage

Mouse Rage , Road Rage , Divorce and the Amygdala

http://andreswhy.blogspot.com

Have you ever flared with visceral fury at a sticky mouse ?

The sequence of events is interesting :

1. A mental discontinuity , as the consciousness is bypassed for immediate threat countering . (the flare)


2. A hormonal flood (the visceral fury bit).


3. A closely following (milliseconds) override as the threat is assessed and dismissed.


4. A gradual relaxation of body-mind systems if the stimulus does not recur soon


5. If it recurs soon (ie about 5-10 minutes) , within the long-term potentiating learning period , the amygdale learns more and more that this is a threat . The reaction becomes stronger and more widespread with every learning repetition.

What is similar between driving a mouse and a car ?
The visual system is very alert , but body-mind is in a mild obsessive-compulsive behaviour state  ( lower serotonin and elevated dopamine ) . Eg , feeling relaxed while concentrating .

Why the flare ?
This relaxed , concentrating and visually alert mental state is found in mammals usually when the response to perceived threat is not fight-or-flight , but fight only .

Some situations:
1. Post-coital (as discussed before) (Protect your genes!)
2. While eating . (Protect your food!)
3. While or after feeding cubs. (Protect your genes!)

This was hard-wired in during mammalian evolutionary history .

The Amygdala.
This brain organ is hardwired for threats to food and genes ,  and also learns threats for which immediate response is required . (The panic button).

Its forte is immediate response , bypassing any smarter but slower data processing .

It’s drawback is that it learns wrong responses to things which are not a threat .

Fast and twitchy beats slow but sure in the survival game.

The Amygdala is not smart or complicated  , but fast . And it learns very , very quickly  ( even once can be enough in a traumatic episode )

So , hardwired in is the mental state :
( VisuallyAlert + low serotonin + high dopamine )  +  Threat  (  Aggressive Attack

Every repetition of the threat reinforces this response , especially if the repetitions fall within the nervous system’s long-term potentiation thresholds ( 5 – 10 mins ) .
Eg , in corporal punishment , there was usually waiting period of 5 mins between lashes : not sadism , but pragmatic learning in action .

A problem is that other things associated with the primary stimulus  get learned as well . Things unrelated to any threat can trigger the response .

This brings us back to road / mouse rage .
The mental state :
( VisuallyAlert + low serotonin + high dopamine )  +  Threat  (  Aggressive Attack
gets reinforced with every repetition  . The amygdala gets sensitized  to this process . You might be exposed to one or two road-rage stimuli a week , but a sticky mouse happens often inside the 10 min threshold . The system gets more and more sensitized.

Interruptions of the ( VisuallyAlert + low serotonin + high dopamine ) state starts getting treated as threats .

An example is hubby relaxing , watching TV after dinner , and wife interrupts . He snaps aggressively at her , without knowing why . The situation escalates from there  to the divorce court .

Associated items get learned as threats just as well as the primary threat . One of the reasons for the extreme bitterness of divorces : each partner triggers extreme threat and anxiety responses in each other . They don’t know why , so they rationalize ,

(Anxiety attacks can be seen as such an associational threat. )

Victims of a security system run amuck .

Reprogramming the Amygdala.

As can be seen from the above , the sensitization grows greater with age . The man might try a new wife , but the same problems surface in different guises . Learned helplessness becomes more prevalent and the system tends to paranoic catatonia . Anything new but with vaguely similar elements to previous threats triggers a threat response .

(Interestingly , this might be why the immune system forgets . Some auto-immune diseases might be due to an inability to forget . Maybe some of the techniques below might help . I refer you to the close similarity between immune-cell interactions and synapses .)

The amygdala needs to unlearn some tricks and desensitize on others . You don’t want to do without cops , but you only want the ones which are not trigger happy .

Will-power
This does not work  , as the amygdale operates through bypassing all the slow smart feedback processes .



Un-learning  and re-learning.
We have the luxury here of two experimental facts that shows that reprogramming the amygdala is possible :

1.Virtual-reality (primarily visual) cures of phobias ( fear of snakes , heights,etc .) has taken place .  So a purely visual input has an effect . This is to be expected from the “VisuallyAlert” component in the original mental state .

2. Direct chemical intervention in the long-term memories .
Re-potentialization
It has been found experimentally that long-term memories in neurons can be repotentialized by presenting the original stimulus . This is to be expected from an evolutionary viewpoint if the organism is past the infantile (neural-pruning) stage .
Use of chemicals like some of the beta-blockers then erases the long-term memory .

Of interest here is that one of the main problems with amygdala-induced anxieties is that the same chemical messengers is used in the inter-brain communication as in the brain-body communications . This means that a threat response in the amygdala is mirrored in the body , and then feeds back to the amygdala . This is then again fed back into the body : the result is an anxiety attack and/or shock . The beta-blocker was originally developed to break the loop in the body , but it seems that it works by erasing the long-term memory .

There is one teeny problem here : a neuron carrying  no memory or a duplicate memory will probably be marked for apoptosis  . We do not want this . So the therapy should include a simultaneous long-term  memory re-learning process . This should also rejuvenate the hippocampus .

What can we do now?

All this sounds like it will take a big lab , lots of white coats and meetings , government approval before some emasculated version might crawl out and cheep at the universe .

Luckily , we already know one easily duplicated stimulus : mouse rage .

We can design a program to do this and be fun too.
Boredom will be a problem , so we use a 3x3 tic-tac-toe grid to soak up the brain’s pattern recognition and counting mechanisms .

The brain’s basic numerical processor can only count to 3 (to be more precise , it can handle < , = , > ) .  The pattern recognition is much more complex , but we want to combine the two .

Basically , it is a Sudoku type grid, but each of the 3x3 elements are spread through time , instead of through space .


We only need pattern recognition , so we only need the traditional “ x” and “o” .
The algorithm:

1. Create a tic-tac-toe that is not a solution (ie no horizontal,vertical or crisscross pattern) . For evolutionary reasons , humans are much more adept at picking out interrupted patterns . And that does not get simpler than xxo .


2. Move the cursor to the nearest x or o that breaks the pattern (the Y square). As it gets near , freeze the cursor and only resume movement if the mouse is moved over it’s little square again . This is the stutter . Don’t worry if it does not cause a rage flare . We are not trying to reinforce the mechanism , but reprogram it at subliminal level . Mark the target square element programmatically


3. Immediately after the stutter ,


4. Move every element in the tic-tac-toe one right and one down in wrap-around .


5. Test if it is solution , If not , loop to 4


6. If it is no solution , try to click on what you think is the Y-square within 30 seconds .


7. If it is correct , count one CorrectY , else count CorrectN .


8. Loop to 4  until 6 minutes have passed .


9. Show score and count set .


10. Loop to 1


11. Proceed until Halt


12. Show scores and sets as a time sequence .

Any suggestions?

Andre

The revenge of Gaia

The revenge of Gaia .

http://andreswhy.blogspot.com
The revenge of Gaia

A book by James Lovelock ( ISBN 13:978-0-713-99914-3 )
This a good summary and call to arms .

He argues that an extreme sense of urgency for remedial steps is necessary , as a major discontinuity ( or tipping point )  looms in about 30 to 40 years at present projected rates of global warming . The Global temperature would rise by about 3 degrees within this time , then suddenly suddenly rise within a year or two by about 8 degrees Celsius after this threshold is reached .

This is the Algal die-off tipping point .
If the global temperature rises by  3  degrees Celsius (ie a total 500 ppm CO2 concentration) global warming causing the rapid extinction of most algae in surface temperate and tropical oceans will result . This would cause a decrease in CO2 downdrawal and decrease in cloud-cover due to lack of DMS condensation nuclei for droplets . The combined effect bounces the global temperature up by at least 8 degrees in a very short time .

Other lesser positive feedback warming effects which are already operative :

1 . Melting of Siberian and Canadian permafrost is releasing large volumes of trapped methane and CO2 . ( Methane is 24 times more powerful greenhouse gas than CO2 ) . Large peat fires is to be expected as dry-out progresses , releasing even more CO2 .

1. Melting of Arctic ice is reducing reflection of light , raising temperatures in arctic regions .


2. Melting of glaciers . Less flow-off during summer leads to less vegetation and more warming .


3. A temperature rise of 4 degrees will see the vanishing of all tropical forests ( The why is tied to the evaporation rate . Even present temperature rises are enough to cause dry-offs in marginal areas , leading to very large fires in the Amazon , Indonesia , Malaysia.) Human exploitation exacerbates this effect .


4. The slowing-down of the Gulf-Stream due to the large-scale influx of fresh water from the melting of the arctic and Greenland ice masses . Actually , the whole planetary ocean current system is affected , but nobody knows to what effect .


5. Solar dimming effect ( due to solar reflection by sulfur pollution aerosols ) decreases . The effect can be very pronounced : apparently , the week-long banning of all flights over the USA after 9/11 caused a whopping 1 degree Celsius rise in temperature over the north American continent .


6. Human activities .


7. Rising ocean levels and extreme wheather is killing vegetation , the rotting of which releases their carbon content as methane or CO2 .

Negative feedback factors:

1. Large scale volcanism : rapid melting of large volumes of ice will destabilize the tectonic balance , especially in the North Atlantic and North Pacific .


2. Lowering of oxygen concentration due to alagal die-off .

3. Humanity will have to supply the rest . All the natural restorative mechanisms seems to result in the extinction of humans .


What does this mean for humans?

The Business as usual scenario:
For about 20 years , things will get slowly worse . More extreme hurricanes , droughts , floods etc . Famines , water-famines and increasing oxygen-famines cause large-scale environmental refugees . Resource wars and genocidal wars increase in frequency and intensity .

The present resource-rich nations withdraw core-survivors to highland areas in the arctic and Antarctic regions . (Notice present fortifications in Urals and bio-banks in Norway and Sweden) The sea-level rises within a decade by at least 7 m as the Greenland ice melts at around 2050 . Antarctic melts are uncertain , but it would be prudent to relocate at least 200 m above present sea-levels .

All regions between Canada-NorthernEuropeSiberia and TierreDelFuega-NewZealand-Antartica become uninhabitable ( or at best , like the sub-sahel at present) . The Hadley-cells in the atmosphere broaden and shift the trade-wind further to the poles . Huge storms , hurricanes , floods , tornadoes . The risen sea-levels means huge expanses of shallow seas over Western-Europe , Eastern-US , Amazon , with concommittant  heating fuelling the storms .

The cooling caused by the cessation of the Gulf-stream on Western-Europe will be initially offset by the global warming ( the estimated effects cancel out : -8  by +8 degrees , but the rising sea-levels will drown most of the West-European plains (return to Tethys Sea) . The shallow seas trap heat and generate unbelievable storms .

The inevitable volcanism caused by the shifting tectonic stresses of lifting ice-masses will cause a short-term cooling , but even bigger storms . Super-volcanoes? Can anybody survive the energy fluctuations ?


Human intervention .

All this seems very pessimistic . Unless something drastic is done , it seems all too possible that no one will survive . Business as usual is not sufficient . Extinction is not only a real possibility , but a high probability .

Essentially , humans will have to increasingly manage the planet . Services supplied free and without conscious thought by the planet (call it Gaia ) ( like breathable air , potable water , edible food , safe domiciles , anti-boredom) , will have to be done by humans if they want to avoid extinction .

The Morality.

Humans have enormous power at the moment . They can easily control the problems of the planet . They have the technology and a lot of the necessary knowledge .

What they lack is a moral basis to mobilize it all .

There is a curious paralysis of the will .

They ask themselves :
“Is it the right thing to do?”
They are quite willing to sacrifice themselves if they are convinced it is the right thing to do (history is full of this) .

But they ask themselves:
Shall we loose a human disease on all the Universe ?
Will humans be like a plague ? At the moment they are contained on one planet . They think they have nearly destroyed their biosphere . Is it moral to release uncontrolled positive feedback forces ?


This is a very general way of looking at it:

The key here is variety and transformation .

Large numbers lead to variety . Variety lead to both conflict and co-operation .

Conflict and co-operation are fractal in combination . Elements have conflicts between  boundaries of co-operation , and these boundaries are in turn the elements of conflicts between bigger boundaries of co-operation , and so forth .

This gives sufficient scope for transformation .

Essentially , this means that any sufficiently large number of elements is bounded : Competitive elements are bounded by  co-operative boundaries , and co-operative boundary-elements are bounded by competitive boundaries . And so forth .

It means you can screw up big time , but you can’t destroy the universe .

Conversely , inaction in a complex situation spinning out of control is the worst possible response .

The moral thing for our society is to intervene .

That perennial problem “ Does the end justifies the means ? “ can be shown to be bounded .
You can try to analyze the effects of any decision in its competition environment until its co-operation boundary , then on all co-operation boundaries , then on all competition environments after that , etc . You will very rapidly reach reach a fuzzy boundary . Like a chaotic system into the future .
An example is climate . Climate and competitive humans is predictable (it is , after all , what we did above with global warming) . However , if co-operative humans are added , the end-result is unpredictable .You cannot say “this end justifies the means” , but only that “my striving towards these possible ends justifies some of these means “.


It is my considered opinion that the right thing to do is not to limit human numbers .

This translates into :
1.No artificial plagues .
2.Release energy technology .
3. Use present technology to the utmost , but in all areas .

Humans will have to manage the planet.

This means building up knowledge of how ecology works . Actively regulating the energy inflow to the planet , as well as the outflow .

These things Mother Earth used to do for us for free . But we’re slowly growing up . Time to stand on our own feet .

For instance , managing the energy inflow to the planet is trivial . Numerous umbrella-type plans are available . All require large masses in orbit , which can be done (and will be if things get bad ) by Orion type thrusters .
There is sufficient variety on the planet at the moment to make it inevitable .

It sounds like a lot of work , but there are a lot of hands . The terran biosphere , excluding humans , can be very closely approximated . If humans are included , decent first and second order approximations can be made .

Humans can run their biosphere .

Andre

FutureWatch Predict

FutureWatch : Prediction ranking by Google

http://andreswhy.blogspot.com

Synopsis:
Search engines like Google cannot examine and rank the future , but they can certainly rank past predictions about the future .

Benefits : the continual feedback will lead not only to the identification and ranking of predictors ,  but hopefully make existing ones take more care (eg think-tanks) . The creation of verifiable marketplace for predictors will lead to much better prediction systems , something a high-tech society desperately needs .

Existing systems:
This ranking is already done to some extent by money ( eg Warren Buffet in investments)  . This is also the only category where the accuracy of predictions is routinely measured  .

Political elections also can be seen as to a measure of the accuracy of a politician’s predictions .

There are a large number of other prediction systems : think-tanks , futurologists , science-fiction writers , scenario-planners , politicians , climatologists , astrologers , mediums , tarot , numerology , etc , etc .

The problem in a fast-changing , high-tech society is that irreversable  changes might take place before this evaluation process has caught up .

Argument for a new system:
It is clear that some individuals and organizations are better at prediction than others . The reason  why might be unclear , but some consistently outperform others .
The problem is to find them . This is the same as ranking them for accuracy above chance . A formidable undertaking .

A large statistical base with built-in feedback is required for any method .
Until now , only money was available as a reliable ranking mechanism .

A Google-type voting ranking system seems another viable method .

Google does not have to decide whether a predictor is better : superior predictors will draw more links , and poorer ones less .

Categorization :  some suggestions
By time and by type.

Scientific : Climate , population , etc
Financial
Economic
Politicians
Fashions
Happiness
Lotto
Etc , etc

Initial set-up problems:
This could be costly (if not impossible) .
Ask for help from your users .
Set up the categories .
Ask the predictors and the users to evaluate each other . This is viable only if a statistically large amount of data can be assembled .

Commercially interested predictors and users have an obvious interest in blowing their own horn and shooting down the competition .

But there is also a large class of vitally interested users in predictions : civil services , farmers , etc .

To repeat , this exercise would only be possible on a large statistical base .

But it will be very lucrative .

Andre Willers

Birdflu Survival Update 7 :CCR5 and Flu

Birdflu Survival Update -7

Dated 27/02/2006

CCR5 and Flu

I noticed that I have not established a link between the two in previous writings available to you .

The easiest way to see it is the pneumonic form of bubonic plague . It has borrowed the flu machinery for quick injection of material into the cell . This is so quickly lethal to the cell that it burns out too fast to be a serious pandemic .

Note that the 1918 Flu was preceded by a world-wide flu-like pandemic , where people got very ill with flu-like symptoms , but very few died . (March 1918) .They also recovered very rapidly , but there seems to have been no immunity response . (They died just as readily in the later November 1918 forms . ) In other words , the immune system had no chance to learn .
Yet workers in sulfur-rich environments were nearly unaffected .

This can be seen as an infection so virulent that it quickly killed the cells it penetrated.
No big problem . One intruder kills one cell , and the clean-up squad (apoptosis or immune system) removes the evidence .

But the immune system hasn’t learned much to counter the attacker in future . The cell has also not learned any handy new tricks the attacker might have . A system that allows controlled access to attackers would be much superior in competition with similar cells than those who do not .

Hence , a general learning channel to import a wide variety of genetic material under controlled conditions evolved . CCR5 seems to be one such a system . It happened a long time ago during the transition to an oxygen atmosphere . Organisms such as Flu or HIV seems to have learned to jam the learning channel open .

There seems to be a feedback element here as well . There seems to be no evolutionary advantage in HIV mutating endlessly to gain entry into an open port . The only advantage is that entry stimulates new immune system molecules configured for the new entry . The HIV uses the cells own machinery to exhaust the immune system . This also how flu works ( ie SARS overloaded immune systems ) . From evolutionary pressures , less lethal surviving varieties would evolve very quickly .

In evolutionary terms , any bug that does not kill off the whole species is a positive learning experience . An open port like CCR5 begs the question why the species is still in existence .

One view is that it is an over-population control .
Since sulfur supply is limited , too many organisms dilute the sulfur concentration per organism . Jamming open an entry-port into a cell will then quickly lead to the the evolution of predatory organisms that will reduce the population , regardless of the immune response . There has been about two billion years for this mechanism to become established.

The question is why such an obvious attack route has not been blocked . The answer is that it has . But it requires chemicals available in high concentrations at the time of the evolution of these ports . Sulfur and methane.

Note the importance of methane-type compounds in epigenetic programming . Sulfur (like in H2S) plays an equally important part .

Stem-cells can be seen as a form of suspended animation . This can be mediated by H2S . Since Sulfur is an element which is not very biologically active , shortages will be noticeable here first .

I have no guidelines on methane , since it’s importance only popped during this analysis . Methylazation as found in epigenetic programming would seem to be adaptation of methane-groups to more sophisticated usages as happened with oestrogen evolution . Still , it would happen easier if there was more methane . The body’s normal supply seems to be from gut-bacteria . A healthy intestinal flora seems more important than ever .

Sulfur concentrations and availability in the environment is still mainly determined by volcanic activity . Sulfur is sequestered into rocks , usually in the form of sulfates .Humans have put a few billion tons back into circulations via fertilizer , but it is drop in the bucket (unlike carbon , where fire does the work , sulfates has to be dug up , transported and laboriously reworked . ) Local high sulfur concentrations in rich agricultural nations might seem to be a problem , but the planetary concentration per person is decreasing .(Most food production in the East is done without artificial fertilizer).

Remember , every human being sequesters at least 15 kg of sulfur in his body . At his burial , this is interred in a grave yard and not recycled immediately . Human feces in the West is not recycled immediately ( usually washed into the sea) . All that sulfur is lost and the rate of replenishment does not keep up .

The result is a lowering of the sulfur concentration , not only in humans , but in the whole eco-system .

This leads to the worrisome conclusion that major pandemics of plant- and animal diseases are in the offing . HIV and Birdflu can be seen as ones .But an equivalent one would be diseases for wheat , corn , rice , cassava , manioc , beans , bamboo or any of the staple foods

The over-population control seems to be alive and operative .






What to do ?
Species survival seems extremely ulikely .

Individual survival:
Get off planet . Lament in your remaining time about the things you lot have been too stupid to maintain (you know , small things like air to breathe , water to drink , food to eat .)

The Terran ecology has been irrevocably disturbed . Any organisms remaining on-planet face a prolonged period of genetic instability (read extinction , retro-viral mutation , etc . )

Here is the joker:

Any humans moving successfully off-planet will need to understand genetics and ecology so well ( to create selfsustaining habitats) that they could redesign the Terran ecosystem . This is doubtful . The easier alternative would be to redesign humans .

Either way , Homo Saps is extinct . Deal with it .

Andre

Birdflu Update -6CCR5 , Sulpher and the 1918 Flu

Birdflu Survival Update -6

Dated 22/02/2006

CCR5 , Sulpher and the 1918 Flu

The 1918 flu attacked sulpher-deprived individuals through the receptor site CCR5 (see previous writings).

The 1918 flu was a direct mutation from birds to humans (ie no intermediate animal or human reactor was involved) . Hence there was no vector of the disease remaining after the human pandemic burned out . No reinfection from a animal source was possible , since there was no animal source and the burn-out happened quickly enough that the virus could not get a foothold in an animal species . So the epidemic vanished quickly .

If the same happens today , we can expect a quick , sharp pandemic involving nations that have been cutting down on sulpher emissions : USA and Europe .

A low-sulpher community (like SA) would be inclined to favour an endemic version of human bird-flu , since the African genetic diversity would be combined with bird-flu in a high-probability scenario of lower mortality ,but endemic reservoirs .

This might have already happened with HIV , since HIV uses CCR5 as well .

A testable prediction then would be that the recent (1 Jan 2006) introduction of low-sulpher diesel in SA would lead to a marked increase in the HIV/AIDS rates .

A worst case scenario would then be a sharp pandemic (50% death rate) in genetically uniform populations , with it then vanishing . However , genetically various populations (ie Africa) will have a lower initial mortality , but will then form a pool of endemic vectors .

Intriguing is the correlation between West Nile Fever and CCR5 . The mutation on CCR5 that gives a degree of immunity to 1918-flu , bubonic plague and HIV leads to a greater susceptibility to West Nile Fever .

Clearly , there is a very old correlation here . Attention is drawn to the high-sulpher content of the environment of the surviving hominins after the Toba event .

Historically , smallpox decreased bubonic plague below pandemic levels by blocking access to CCR5 . Suspicion exists that other diseases using CCR5 (like HIV) is now increasing because this blocker has been removed .

One wonders if the disruption in smallpox vaccination during WWI and the low-sulpher environment led to a random mutation of the bird-flu gaining sufficient foothold to become an epidemic .

Why should viruses be so sensitive to the sulpher concentration ? Because cells are so sensitive to sulpher concentrations . Attention is drawn to the cascade of epigenetic switches caused by a 80 ppm concentration of H2S , switching off the genes of even advanced mammals in a very precise sequence . (Suspended animation : see Scientific American) (Total anoxia does the same) . This is a partial apoptosis , since the total breakdown of the cell does not take place , but harmful oxidizing elements are apoptised .

What is even more intriguing , is that restoring oxygen leads to revivication without major support mechanisms . Ie , it is programmed in , and the program of partial apoptosis and anapoptosis is still fully operative (ie still used in routine cell operations) .

Whipsawing.
The suspicion arises that the first multi-cellular organisms evolved to be able to survive in both oxygen-rich and oxygen-poor , sulpher-rich environments . Initially , the ur-cell could do both , but not very well . Putting a cell-wall in between increased efficiency drastically . Parasites evolved for each mode , but would tend to specialize on aerobic or anaerobic after the schism got established by Darwinnian selection of more efficient phenotype preferred by a particular gene structure .

The joker here is the immune system . It places a bias on the organism , favouring the survival of positive changes , either aerobic or anaerobic .

So , breathing in succession 80 ppm H2S and pure Oxygen , while taking antibiotics should see off any cellular competitors in quick fashion .

Speculations:
The increase in asthma can be more accurately correlated to the lack of “mephitic vapours” . Ie the smells from the toilet . Note that the whipsaw effect above is a cascade , and that the process can be interrupted by the lack of a single element in the cascade . The lack of sufficient H2S concentration in developmental stages can lead to severe immune system imbalances . Note that small boys like bad smells . Why?

This leads to the irresistible conclusion that continuous washing is bad for human males , since it impairs their immune system . I always knew that !

Smell seems to have been neglected . If 80 ppm H2S triggers the organism into stasis (an experimental fact ) , smells ( or more exactly , chemical signals ) can cause huge effects . It is not the smell exactly . The chemical throws a switch in the genetic machinery of the cells . The result can be out of proportion to the concentration (will have to be , as concentrations are diluted by the volume of space .)

Epigenetic programming is obvious . Post-natal epigenetic programming using whipsawing H2S techniques might persuade some cells into becoming stem cells . Note that regenerators like crocs , tadpoles , etc seek anaerobic environments

Note that the techniques are simple and reasonably risk-free .

You can do this at home , especially as last resort .

Can it make you younger?
Whipsawing is a form of post-natal epigenetic programming . It definitely slows ageing , but regeneration might take a bit more work . Crocs and sharks keep on growing , until they cannot be supported by their ecosystem . I see no reason why humans should be different.

The only way old humans could survive is by emigrating to the outer spaces . Imagine a universe populated by concentric rings of bores . Yuck.

Andre

Blackout! The Cost of the Margin .

Blackout !
The Cost of the Margin

A quick theory overview:
For every additional dollar spent on an existing system , we get R dollars in value in return . Seen over time , R is initially much bigger than one , but decreases as the system matures and complexity increases ( ie the Law of Diminishing Returns) .

As the Return R decreases to one , risk assessment plays a bigger and bigger role . Riskier investments are not made or , more importantly , no precautions are taken against the more unlikely risks .

Simultaneously , the complexity of the system increases ( by definition , the simple and easy things get done first .) The number of things that can go wrong increase exponentially . If humans are involved , the system is non-linear as well . In other words , an unlikely outlier can feedback to affect the whole system . But no effort or expense is made to prevent the unlikelier problems . Hence , it is only a matter of time before the system is negatively affected in a major way .

It is a “ Damned if you do , damned if you don’t “ scenario .
Trying to cover the exponentially increasing number of risks must bankrupt any system .
Trying to prevent the system becoming more complex in a competitive environment will lead to such a relative disadvantage that the system (or its CEO ! ) will suffer a catastrophic drawdown .

A Civilization is composed of many systems like these , at various stages . Any individual system will eventually self-destruct , but innovation can create new systems .

Any freezing (or slow-down) will result in destruction by a competitor.
If it is a monopoly , there is no competitor . The eventual collapse will be much quicker and more devastating .

There is one out : a non-competitive environment . Note that the civilizations with the longest history of stability ( Egypt , Christian , Islam , China , Buddhist , Hindu) managed to create both real and virtual pockets of non-competitiveness inside their boundaries (ie Monasteries , Universities ) .


A case study : ESKOM in South Africa .

ESKOM (Electricity Supply Commission) was originally founded to smooth electricity supply from private and municipal electricity generators to the gold mines and their supporting industries on the Rand . It enjoyed one insuperable advantage : by Act of Parliament , it could not be sued for any losses its customers suffered due to
interruption of electricity supplies .

It used advantages of scale , cheap copper (for the wires) and legislation to become the sole supplier of electricity in South Africa . An example are the farmers: many farmers had their own generators , but were compelled by legislation to pay connection fees , even if they did not use ESKOM power . So eventually , they were forced to become ESKOM customers out of economic necessity .

The result was an enormously complex web wires strung all over South Africa to every home . After 1994 , the demand for power exploded . The cost of copper wire exceeded the revenue from any supply through them or the cost of safeguarding them All to be done without raising the cost above inflation level . An impossible task .

So the cost of power has been rising inexorably in real terms .


The Western Province Blackouts 2006

The City of Cape Town used to be self-sufficient in its power requirements . ESKOM promised cheaper and guaranteed power . The local power stations were phased out , except for the Koeberg nuclear station . Maintenance in respect of unlikely events ( like supervision to prevent a bolt being dropped into one of Koeberg’s main generators , cutting undergrowth under transmission lines , cleaning insulators on transmission lines after soot ,birdshit and dirt build-up , wear-and-tear on transformers and switchgear , etc) was not done .

Now the network is under stress , and the most fragile elements are failing first . Hence , the oldest , richest areas which first got electricity tend to be most affected as the engineers try to bring the network into stability while doing decades-needed maintenance . Newly revamped areas (like V&A , Sea Point) seems to be unfairly exempt .

Prognosis : not good.

ESKOM’s marginal return is less than one . If it remains the only electricity supplier , it’s collapse will drag down the whole sub-continent , or require exponentially increasing government subsidies / prices .

A solution is to reduce complexity voluntarily instead of waiting until outside factors does it for you .

A nice way that retains power for all is to split the big cities from the rural areas . The big cities are to be encouraged to build their own stations (eg pebble bed reactors) , while most of the complexity of the rural areas can be offset by renewable energy sources like wind or solar power . Note that central distribution of electrical power via valuable metal wires is never going to have a marginal return bigger than one (ie it will always have to be subsidized) . It is also in our civilization’s interest to keep the rural areas independent from the cities .

Will this happen?

You judge : it is your future.

Andre

Jethro Tull – Super Hero

Jethro Tull – Super Hero

In 1701 an Englishman called Jethro Tull invented the seed drill . By quickly and reliably planting seeds at the optimal spacing and depth , this invention enabled about a fourfold increase in yield within one season .

This invention created the largest pulse of wealth in history . Bigger than the invention of fire . Bigger than the invention of agriculture . Bigger than the invention of the internal combustion engine or transistor .

It kick-started the Industrial Revolution .

The reasons:
Most wealth was agricultural.
The increase in wealth was within one season . Malthusian population growth would take about 2 to 3 generations to catch up . Imagine getting a 400% raise in your salary in one year without inflation . This was the effect . This pulse of wealth propagated onwards , giving leisure and incentive to inventors . (ref Baby Boomer Pulse)

The result was a pulse of wealth stimulating other individuals to make similar inventions . The Age of Reason was born . The problem was the massive increase in population made possible by the efficient mechanized systems .

The large number of surplus males and the means to support large armies led to the First Large War (Napoleontic) . This gave the Age of Reason a knock (Nationalism), but you could still state unpopular beliefs without being killed for it . The Second Large War (WWI) destroyed the Age of Reason and ushered in the ideologies (Communism , Marxism , Fascism , Capitalism ). If you stated an unpopular belief , you stood a good chance of being heavily penalized for it . The demise of ideologies collapsed the system back to Religious Fundamentalism , where you can be killed for stating an unpopular belief . The Age of Reason is finally dead . This is the state at circa 2006 AD .

The Age of Reason only lasted a century , but gave rise to our present wealth .

When evaluating ideas like that of Huebner ( see “Waiting for the lights to go out” in Sunday Times of Oct 16 2005 ) , it is important to remember that changes come in pulses . Things might seem to be going to hell in a hand-basket (cf horse-poop in New York circa 1890’s) , but discontinuities generate pulses of change and wealth . You might as well try to explain a transistor using Newtonian mechanics . In other words , analyzing pulses of change as simple statistics of numbers of people over time is garbage .


Is Reason a Good Thing ?

The human race is trembling on the brink of extinction because of the inability of reason to resolve the problem of population and competition .

Example: China
Twice China has limited expansion:
1 Destruction of exploration fleets in 15 th century : the result was Western domination 200 years later (not very long) .
2 One child families in the 20 th century . The Result was a pulse of wealth (as more resources was devoted to education of the lone children) , but their main competitor India is exceeding their population .



Reason (ie logic) has two major drawbacks :

1 The Universum (Venn) is unbounded . This has been proven rigorously in 1906 (Principia Mathematica by Whitehead and Russell) . This means that no theory of everything is possible . ( If you think you have a TOE , you can always define items outside the delineated boundary which , by definition , do not fit inside TOE.)
2 Chaos Theory shows that that even inside a deterministic system , time-sequence predictions are only possible with varying degrees of error (cf weather) . The number of near equipotential branches grow exponentially after a finite number of time units .


This means that the End Does Not Justify The Means .
At best , a prediction must have some sort of probability margins .
This argument is only valid if no time-travel is possible .

Is there hope?
Our present locale (the sidereal Universe) can be expressed as Locale I , defined by the principle that conservation laws are possible There are rules !. Seeing Locale I as delineated , means pockets of being (particles) , space , time and curvaceous space-time. But it is unstable iro non-conservation systems (defined as Locale II). Locale I is maintained artificially by Locale II .

Locale I is maintained primarily as a nursery (try bringing up kids where there are no rules!) , but also as a holiday (going primitive) and trading/warfare locale . This is because interactions can be enforced in Locale I (ie the rules:conservation of something) , whereas in Locale II you cannot force an interaction .

The above reasons work better if there is a lot of variety .Also , the usual reasons of humanity , looking after the planet , etc , etc do not apply except as insofar they illustrate a lesson . In other words , nobody is innocent except the children , and they get the lessons they need .

What does this mean ?
There will be a variety increase soon .
This can be
1. Massive depopulation (plague , eco)
2. Aliens in space
3. Aliens in time
4. Both (most likely : there is only one singularity per universe : the first contacts from the local viewpoint will be on most similar interfaces.)
Merry Christmas
The Alien.