Immortality Update 5 : ExRad
Andre Willers
25 Dec 2013
“I love it when a plan comes together!” Hannibal Smith , A-Team .
Synopsis:
A simple molecule that stimulates the repair of radiation
and free-radical damage . Actual DNA and bone marrow repair .
Discussion :
A simple molecule to trigger old-age repair .
A more complicated molecule to repair DNA and free-radical damage
Ex-Rad (or Ex-RAD),
also known by the code name ON 01210.Na, is a drug developed by
Onconova Therapeutics and the U.S.
Department of Defense.[1][2] This newly developed compound
is said to be a potent radiation protection agent. Chemically, it is the sodium
salt of 4-carboxystyryl-4-chlorobenzylsulfone.[3]
The results of two Phase I clinical
studies in healthy human volunteers indicate that subcutaneously injected
Ex-Rad is safe and well tolerated, with "no evidence of systemic side
effects".[4] A study in mice demonstrated
the efficacy of Ex-Rad by increasing the survival rate of mice exposed to
typically lethal whole-body irradiation. The study tested oral and parenteral administration of Ex-Rad for
both pre- and post-exposure radiomitigation.[1]
Research on Ex-Rad has involved collaboration with the Armed
Forces Radiobiology Research Institute (AFRRI), the Department
of Biochemistry and Molecular & Cellular Biology at Georgetown University, Long Island
University's Arnold & Marie Schwartz College of Pharmacy, and
the Department of Oncological Sciences at the Mt. Sinai
School of Medicine.[1]
Onconova suggests that Ex-Rad protects cells exposed to radiation
against DNA damage, and that the drug's mechanism of action does not involve
scavenging free radicals or
arresting the cell cycle. Instead,
they claim it employs a "novel mechanism" involving
"intracellular signaling, damage sensing, and DNA repair pathways".[4] Ex-RAD is a chlorobenzylsulfone
derivative that works after free radicals have damaged DNA. Onconova CEO Ramesh
Kumar believes this is a better approach than trying to scavenge free radicals.
“Free radicals are very short-lived, and so the window of opportunity to give a
drug is very narrow,” he says. In cell and animal models, Ex-RAD protectshematopoietic and gastrointestinal tissues from radiation
injury when given either before or after exposure.[5]
3.Combine NAD and Ex-Rad .
A potent combination of DNA and Epigenetic signalling
molecules , triggering self-repair and roll-back .
Note the Sulfur atom in ExRad : a tie-in to the H2S
hibernation systems . See http://andreswhy.blogspot.com/2008/11/hibernation-and-cryogenics.html
4.The trigger seems to involve access and/or creation of pockets
of DNA specially saved for roll-back operations .
Reasonable , as pockets of cancers can be seen as high-risk
bio-labs evaluating risky chemicals on fast-forward .
As discussed previously .
5. If something still goes wrong :
Then use CRISPR to correct DNA , then use Ex-Rad and Nad .
6.The tools now exist for a serious attempt at anti-agathics
.
7. Will this cause serious social problems ?
Ie will the old keep a death grip on resources ?
8.Ho-ho-ho !
I used to think so too . But think it through .
The bottleneck is memory . The human sensorium is simply too
small to remember everything .
What did you have for breakfast 60 years ago ?
Memory , and the mirror of personality is a travelling wave
, dropping old stuff and assimilating new experiences .
For societies , they compensated with Families , Gens ,
Clans , Dynasties , tribes , Nations , etc . Group memory structures .
You know what happened to them .
Unstable as hell . (See what happened to Standard Oil)
Enhanced humans (ie longevity + AI extensions ).
They don’t remain human for very long . Lose interest in
childish games .
9.Food for all these long-lived ones .
9.1 Present decision makers will have to channel much
greater resources into fundamental research and space travel , as they
themselves will survive to need it .
9.2 There is another semi-stable point : drastic
depopulation and an Old-Egyptian style Eco-Religion trying to keep the lid on .
This solution is unstable because of chaotic influences
outside control of anybody .
Merry Xmas to all .
Andre
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