Fast train to Longevity
Andre Willers
9 Jan 2015
Synopsis :
We use Ravioli to deliver H2S and adjuvants indistinguishable from endogenous H2S . 3D
Printers are advisable . Endurance athletes will benefit greatly .
Discussion :
1.See Slow Train to Longevity in Appendix AA or http://andreswhy.blogspot.com/2014/12/slow-train-to-longevity.html
The longevity effect is because of the hibernation effect of
H2S .
It slows down metabolisms of different systems like immune
system , inflammation systems , sugar , etc at different rates .
2.Endogenous and exogenous H2S .
There seems to be little difference , except concentration
and whether introduction is extra-cellular(exogenous) or intra-cellular
(endogenous)
3.We want to introduce 80 ppm H2S from the outside that is
indistinguishable from endogenous H2S .
We make Ravioli filled with 80 ppm H2S (dissolved) and
formic acid .
Cook (boil) for about 5 minutes (not too long) .
Eat with any sauce , but hold the melatonin .
4.How H2S works .
“Hydrogen sulfide under high pressure has
recently been demonstrated to undergo superconducting
transition at 190K, the highest temperature
superconductor known to date. “
Only -83 Celsius . Liquid
nitrogen freezes at 63 K (−210 °C) .
The lowest natural temperature ever directly recorded at
ground level on Earth is −89.2 °C (−128.6 °F; 184.0 K), which was at the Soviet
Vostok Station in Antarctica, on July 21, 1983. Thus , H2S can be
superconductive (but at high pressure) on the Earth’s surface .
Wow ! That is weird for such a simple molecule . I have no
idea whether it is relevant .
“Hydrogen sulfide is slightly soluble in water
and acts as a weak
acid, giving the hydrosulfide ion HS− (pKa = 6.9 in
0.01-0.1 mol/litre solutions at 18 °C). A solution of hydrogen
sulfide in water, known as sulfhydric acid or hydrosulfuric
acid, is initially clear but over time turns cloudy. This is due to the
slow reaction of hydrogen sulfide with the oxygen dissolved in water, yielding
elemental sulfur, which precipitates out.”
It has limited shelf life .
5 How .Formic Acid works .
This is to penetrate the cell walls and make the H2S like
endogenous H2S . The concentration will have to be determined , but about the
same as a nettle .
Use nettle tea if formic acid hard to obtain . See http://www.webmd.com/vitamins-supplements/ingredientmono-664-stinging%20nettle.aspx?activeingredientid=664&activeingredientname=stinging%20nettle
See Appendix BB or http://andreswhy.blogspot.com/2013/07/rabies-alzheimers-and-formic-acid.html
6. Inflammation example
“Conclusions and implications:
Whereas exogenous H2S delivered to the knee
joint can produce a significant anti-inflammatory and anti-nociceptive effect,
locally produced H2S exerts little immunomodulatory effect. These
data further support the development and use of H2S donors as potential alternatives (or complementary therapies) to
the available anti-inflammatory compounds used for treatment of joint
inflammation or relief of its symptoms.”
Bon Appetit for life
Andre
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Appendix AA
Slow train to longevity
Andre willers
28 Dec 2014
Synopsis:
Endogenous H2S increases lifespan .
Discussion :
1.H2S is back !
H2S and the molecular mechanics of
freezing metabolisms .
See Appendix A below for latest
findings . Endogenous H2S creation increases lifespan . A sort of fast
hibernation .
2.Why endogenous H2S?
Safety switch . Organisms without it
simply goes into hibernation at the first volcanic eruption , and gets eaten by
those with the safety switch .
3. How it works .
http://www.jneurosci.org/content/16/3/1066.short
(1) an H2S-producing
enzyme, cystathionine beta-synthase (CBS), is highly expressed in the
hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the
production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine,
enhances H2S production, indicating that CBS contributes to the production of
endogenous H2S. We also show that physiological concentrations of H2S
selectively enhance NMDA receptor-mediated responses and facilitate the
induction of hippocampal long-term potentiation. These observations suggest
that endogenous H2S functions as a neuromodulator in the brain.
4.Also the general
metabolism .
Supplements
http://nccam.nih.gov/health/supplements/SAMe
This gives all the foods to avoid
.
CBS activator,
S-adenosyl-L-methionine, enhances H2S production
5.Fasting every third day will then
work . But stop MSM addititives during fasting.
6. Intermittent fasting
Eat your heart out .
Andre
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Molecular mechanism behind health benefits
of dietary restriction identified
Increasing endogenous hydrogen sulfide production during dietary
restriction plays a major role in delivering the benefits of longevity and
stress resistance.
Credit: Image courtesy of Harvard
School of Public Health
A new study led by Harvard School of Public Health (HSPH)
researchers identifies a key molecular mechanism behind the health benefits of
dietary restriction, or reduced food intake without malnutrition. Also known as
calorie restriction, dietary restriction is best known for its ability to slow
aging in laboratory animals. The findings here show that restricting two amino
acids, methionine and cysteine, results in increased hydrogen sulfide (H2S)
production and protection against ischemia reperfusion injury, damage to tissue
that occurs following the interruption of blood flow as during organ
transplantation and stroke. Increased H2S production upon dietary restriction
was also associated with lifespan extension in worms, flies, and yeast.
Although H2S gas is extremely toxic in high amounts, low levels
present in naturally occurring sulfur springs have long been associated with
health benefits. Mammalian cells also produce low levels of H2S, but this is
the first time that this molecule has been linked directly to the health
benefits of dietary restriction.
"This finding suggests that H2S is one of the key molecules
responsible for the benefits of dietary restriction in mammals and lower
organisms as well," said senior author James Mitchell, associate professor
of genetics and complex diseases. "While more experiments are required to
understand how H2S exerts its beneficial effects, it does give us a new perspective
on which molecular players to target therapeutically in our efforts to combat
human disease and aging."
The study appears online December 23, 2014 in Cell.
Dietary restriction is a type of intervention that can include
reduced overall food intake, decreased consumption of particular macronutrients
such as protein, or intermittent bouts of fasting. It is known to have
beneficial health effects, including protection from tissue injury and improved
metabolism. It has also been shown to extend the lifespan of multiple model
organisms, ranging from yeast to primates. The molecular explanations for these
effects are not completely understood, but were thought to require protective
antioxidant responses activated by the mild oxidative stress caused by dietary
restriction itself.
First author Christopher Hine, research fellow in the Department
of Genetics and Complex Diseases, and colleagues demonstrated that one week of
dietary restriction increased antioxidant responses and protected mice from
liver ischemia reperfusion injury, but surprisingly, this protective effect was
intact even in animals that could not mount such an antioxidant response.
Instead, the researchers found that the protection required increased
production of H2S, which occurred upon reduction of dietary intake of the two
sulfur-containing amino acids, methionine and cysteine. When the diet was
supplemented with these two amino acids, increased H2S production and dietary
restriction benefits were both lost.
The investigators also found that genes involved in H2S
production were also required for longevity benefits of dietary restriction in
other organisms, including yeast, worms, and flies.
"These findings give us a better understanding of how
dietary interventions extend lifespan and protect against injury. More
immediately, they could have important implications for what to eat and not to
eat before a planned acute stress like surgery, when the risk of ischemic
injury can be relatively high," said Hine.
Journal Reference:
1.
Christopher Hine, Eylul Harputlugil,
Yue Zhang, Christoph Ruckenstuhl, Byung Cheon Lee, Lear Brace, Alban
Longchamp, Jose H. Treviño-Villarreal, Pedro Mejia, C. Keith Ozaki,
Rui Wang, Vadim N. Gladyshev, Frank Madeo, William B. Mair,
James R. Mitchell. Endogenous Hydrogen Sulfide Production Is
Essential for Dietary Restriction Benefits. Cell, 2014;
DOI: 10.1016/j.cell.2014.11.048
Appendix BB
Tuesday, July 16, 2013
Rabies , Alzheimers
and Formic acid
Andre Willers
17 Jul 2013
Synopsis :
Formic acid opens the
Blood Brain Barrier(BBB) . This enables the immune system to interact with
brain cells . Only to be used in very controlled circumstances .
Discussion :
1.The Blood Brain
Barrier evolved from skin . See Appendix A.
2.Formic acid bypasses
skin . See Appendix B
3.In extremis :
If somebody is dying
in convulsions from rabies , an infusion of formic acid might help .
Under more controlled
conditions , it might help for some forms of brain cancers and plaques . (Eg
alzheimers)
The immune system is
quite capable of seeing these pests off , but is prevented by the Blood Brain
Barrier .
4.Creating a portal in
the BloodBrainBarrier .
4.1 A pulse of formic
acid to open the barrier .
4.2 A pulse of botox
to freeze it open .
4.3 Can be done in one
capsule with hydrophilic and hydrophobic ends .
5.The cost :
Memories . The BBB
evolved as a safeguard for the identity-complex . The immune system will scrub
this .
The person won’t die
physically , but the personality won’t survive .
6.Pain , etc
Long nerve damage (eg
peripheral neuropathy) .
Micro-injections of
formic acid is analogous to botox . It enables the body’s repair mechanisms .
Should help with
auto-immune diseases like arthritis .
Maybe even
degenerative diseases like Alzheimers .
7. Or ants
.
8.A bit of Formic acid
with the Botox will make it permanent . But also reduce brain degeneration .
Beauty and Brains in
Old age.
This would be a
disaster if not for the rapid mutation rate in mental processes and memory
caused by formic acid .
Live forever , but
better keep a diary .
Andre
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Appendix A
Rabies[edit]
During lethal rabies
infection of mice, the blood–brain barrier (BBB) does not allow anti-viral
immune cells to enter the brain, the primary site of rabies virus replication.
This aspect contributes to the pathogenicity of the virus and artificially
increasing BBB permeability promotes viral clearance. Opening the BBB during
rabies infection has been suggested as a possible novel approach to treating
the disease, even though no attempts have yet been made to determine whether or
not this treatment could be successful.[original r
This post was
published to Andre's Why at 05:05:06 PM 2013/01/12
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Appendix B
Appendix B
Training the Immune
System
Andre Willers
12 Jan 2012
Synopsis:
Commercially available
desensitization technologies are now available for Milk , Peanut and DustMite
allergies .
Discussion :
1.This involves
skin-patches , exposing the organism to prolonged exposure to the
allergy-producing chemicals , but at such low levels that anaphylactic shock is
not induced .
2.But , the learning
systems of the Immune system are engaged (Dentritic cells)
See Appendix I
3.At least , some
clinical testing of the three products available (milk , peanuts , dustmite
asthma) is being done .
See
http://www.dbv-technologies.com/en/ .
4.This is but a
high-tech approach to the old-age approach to test for poisons . Put a sample
of the material to be tested on the skin . Watch what happens .
Used from
Neolithic times . And present day doctors for allergies .
5.The Trick :
The skin usually
prevents deleterious amounts of the allergy –producing chemical from passing through
.
6.Plant-Herbivore Wars
:
Some plants have
developed ways of bypassing this barrier . Contact poisons . Like itching
thistles , stinging nettles , etc.
Do not use the patches
if you might be exposed to stinging nettles or their ilk .
7.Opportunity :
Instant safe reprogramming .
These poisons can be
used to deliver nano-levels of active allergens directly to the dendritic cells
. Shortening the training period to fractions of a second .
8.This opens a whole
new can of worms .
Near-instantaneous
reprogramming of the immune system will have obvious shock effects . But this
can be quite useful in things like melanoma’s .
See Appendix II .
Since only nanograms
of the allergen is required , addition of the nettle-bypass chemicals will
flood the dentritic cells with maybe too much information . (It is not a smart
system).
But in the case of
overproduction of particular allergens , these will train the immune system .
Like cancers .
Note that the
gut-system is but internal skin .
9.The buccal interface
:
This will take place
mostly in the mouth .
Very little survives
the stomach acid-bath .
So swirl the
nettle-soup in the mouth .
See Appendix III A
Your mother was right
. Don’t gulp it down .
10 . Nettle-active
capsules
Nettle-active Capsules
that only dissolve past the stomach will need some thorough testing .
Buccal systems have
some strong safeguards (they handle garlic (Allicin) , after all .
One of the most proficient cell-killers)
But something like
this would of great use in Crohn’s Disease and other intestinal auto-immune
diseases .
For the active
chemicals , see Appendix V A
11.Auto-immune
Diseases :
These are obvious
candidates . Especially that nasty Arthritis . A nettle-system patch combined
with an alternate target like dust-mites (available) can make short work of
arthritis .
12.Diabetes II
See Appendix III for a
cure
You will also need
Phene Systems : see Appendix IV
The exact molecular
mechanism of Insulin docking to the Cell-wall has recently been worked out . It
is an active system .
Portions of the
Insulin molecule folds out to match portions of the cell-wall that also
outfolds to latch together .
Which is why you need
phene-systems .
The trigger seems to
be formic acid .
See Appendix V A .
Formic acid is used
extensively by insects and plants to bypass phene barriers . A simple molecule
(as expected . It is very old-about 3 billion years)
It is an azeotrope
(See http://en.wikipedia.org/wiki/Azeotrope
Azeotrope
From Wikipedia, the
free encyclopedia
Vapor-liquid
equilibrium of 2-propanol/water showing azeotropic behavior
An azeotrope (pron.: /əˈziːətroʊp/ ə-zee-ə-trohp or pron.: /ˈeɪziətroʊp/ ay-zee-ə-trohp)
is a mixture of two or more liquids in such a way that its components cannot be
altered by simple distillation.[1] This happens because, when an
azeotrope is boiled, the vapor it produces has proportionate constituents as
the original mixture.
These chemicals are
favoured by evolution because they are invariant to phase change . They keep on
working at any state.
Used extensively in
hibernation systems to bypass cellular barriers . See Appendix VI A .
The molecule seems to
have only five nexi , yet it seems able to collapse quantum – wavefronts ( see
http://andreswhy.blogspot.com/search?updated-min=2012-01-01T00:00:00-08:00&updated-max=2013-01-01T00:00:00-08:00&max-results=50
)
Can it be simpler ? I
don’t know . Four nexi will have to be designed , but I might be wrong .
Formic acid seems to
be a sine-qua-non for multicellular organisms .
Quite surprising .
13, To get back to
Diabetes II
We use the Buccal
Transform :
Make a solution of
Formic Acid < 2% , with a dash of serotonin and histamine . Add the active
thingie you want the immune system to learn about .
13.1 Diabetes II
Add about 1 teaspoon
of sugar/20 ml of lukewarm water . Stir and rinse the mouth extensively . See
Appendix II A .Spit it out .
The spitting out is
vital . The pulse of sugars must not reach the descending duodenal .
What is happening ?
The preparation system
is notifying the descending duodenal system (see Appendix III A ) . A lot of
sugar is coming . Then it does not arrive .
This is a pretty
stupid system . After 3+1 iterations it stops believing the incoming signals
and stands down .
Ordinary phene systems
apply . A quick cure .
13.2 Other intestinal
problems can be handled in an analogous fashion .
14.Outer-Skin problems
.
Use Formic acid ,
serotonin and histamine patches(in correct proportion) plus target chemical .
Simple . Quick , too ,
with the Formic Acid .
14. Who would have
thought ?
Ants are caught in a
terrible cellular trap . They are forced into a communal mind by formic acid .
An interesting aside :
Bioengineering ants
not to excrete formic will have interesting results . I would recommend
Biolevel 5 Controls
15. Oxytocin and
Formic Acid
Oxytocin is an
expanded version of formic acid . Compare the molecular structures
See http://en.wikipedia.org/wiki/Oxytocin
and http://en.wikipedia.org/wiki/Formic_acid
Oxytocin has only one
ring , so is topologically equivalent to dopamine .
16 .Does any molecule
not collapse quantum-wavefronts ? It only seems like it . We are looking at a
very specific sub-group .
Who would have thought
that eating ants kick-started human evolution ?
“Feeling antsy is the
beginning of wisdom “ Buddha-Ant
Andre
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Appendix I
http://www.medicalnewstoday.com/releases/225620.php
About VIASKIN®
Technology
When the VIASKIN®
patch containing a specific allergen is applied to the skin of a patient with
an IgE-mediated allergy - such as peanuts or milk - the allergens are deposited
locally on the skin and are captured specifically by the skin's
immuno-competent cells. This triggers the modulations of the immune responses.
The epicutaneous exposure is non-invasive: the skin naturally prevents the
allergen from entering the bloodstream and thereby dramatically reduces the
risk of inducing anaphylaxis. The VIASKIN® patch is designed to be easily
and painlessly applied by healthcare professionals and also by the patient or
his/her parents at home, which facilitates compliance with the treatment.
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Appendix II
http://en.wikipedia.org/wiki/Nettle_soup
Nettle soup
Nettle soup is a
traditional soup prepared from stinging nettles. Nettle soup is
eaten mainly during spring and early summer, when young nettle buds are
collected. Today, nettle soup is mostly eaten
in Scandinavia and Eastern Europe, but historically consumption
of nettles was more widespread. Nettle stew was eaten by inhabitants
of Britain in the bronze age, 3000 years ago.[1]
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