Immortality Update 1.0
Andre Willers
5 Nov 2013
Synopsis :
It is not sufficient to inhibit death . Regeneration needs
to be stimulated , too.
Discussion :
1.As suspected , there are natural regeneration stimulants .
See Appendix A
2.These have to be kept under control .
3.Else cancers occur .
4.Just slow it down .
5. Use H2S as in pre-programmed hibernation .
See Appendix B and my previous posts on hibernation http://andreswhy.blogspot.com/2010/11/updates-01.html
and
6. Foods :
Oral ingestion of EET is possible . See Appendix C
7. Potassium and kidneys .
See Appendix D
Only two fatty acids are known to be essential
for humans: alpha-linolenic acid (an omega-3 fatty acid) and linoleic acid (an omega-6 fatty acid).[2][3]
8.Regenerating
kidneys .
8.1 Two tbs flaxseed oil per day (omega 3) (Faster)
8.2 One
tbs fishoil per day (omega 6) -> EET (Faster)
8.3 One
tsp bicarbonate of soda (to reduce blood acidity) (Slower)
8.4 A potassium tablet . (To activate systems See
below) (Faster)
8.5 MSM :
about 1500 mg /day . H2S mechanism . (Slowing)
8.6 Eat Mushrooms
: must be organic . See Appendix E . Activates EET .
9.This
should regenerate kidneys .
10. It
can easily be adapted to other organs .
11.
Resetting the telomeres .
Wait for
the next thrilling episode .
Regards
Andre
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Appendix A
Natural chemical boosts organ regeneration
·
12:44 30 July 2013 by Andy Coghlan
·
Magazine issue 2928. Subscribe and save
·
For similar stories,
visit the In Brief Topic
Guide
Your body naturally contains a chemical that can
boost organ regenerationand
speed up wound healing.
Epoxyeicosatrienoic acids (EETs) help new blood vessels to form,
so Dipak Panigrahy at Harvard Medical School in Boston and colleagues wondered
whether they might also accelerate other types of growth. To find out, they
injected mice with EETs straight after the surgical removal of a lung or part
of their liver.
Four days later, treated mice had 23 per cent more tissue growth
in their remaining lung or 46 per cent more liver growth compared with mice
that had received a placebo injection. Applying EETs to wounds in mice
shortened healing time.
The team also showed that EET concentrations in blood trebled in
the week after human liver donors had undergone surgery.
"This looks promising," says Dan Weiss, who studies lung
regeneration at the University of Vermont in Burlington.
"EETs have been overlooked in regeneration schemes, so this
might provide a window of opportunity."
Journal reference: PNAS, DOI:
10.1073/pnas.1311565110
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Appendix B
DARPA Takes on Suspended Animation: Zombie Pigs, Squirrels,
and Hypersleep
By: Surfdaddy Orca
Published: January 7, 2010
Remember all those SF movies where it takes suspended
animation to travel to a distant planet or galaxy? Ripley, the buff female
protagonist in the film Aliens, spends 57 years in “hypersleep” — without aging
— before being rescued. The Defense Advanced Research Projects Agency (DARPA)
is now funding research that may one day bring humans to a zombie-like form of
hibernation. The motivation, however, is not so much space travel as emergency
trauma care for wounded soldiers on the battlefield.
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Actual hibernation occurs when an animal such as a squirrel
goes into a state of suspended animation: heart rate, metabolism and body
temperatures drop significantly. When a mammal is in hibernation, its body
temperature is usually only 2-4ºC above freezing (as opposed to perhaps 38ºC),
oxygen consumption is 2% of normal rates, and heart rate decreases by a factor
of one hundred.
DARPA is committing $9.9 million to the Texas A&M
Institute for Preclinical Studies (TIPS) to research how hydrogen sulfide can
block the body’s ability to use oxygen and induce a state of suspended
animation. Because they have a cardiovascular system similar to humans, TIPS
researchers Theresa Fossum and Matthew Miller think they can accurately predict
human results from trials with anesthetized pigs. Using swine, the researchers
are testing various compounds — some containing hydrogen sulfide — to find one
that can safely keep the hemorrhaging animals “as close to death as possible.”
Here’s a video on the TIPS research:
As reported by Popular Science, nearly half of soldiers
killed in action die of severe blood loss after being wounded by gunshots or
IEDs. When emergency trauma care is administered during that first “golden
hour,” soldiers’ odds of survival are relatively good, but after that their
odds begin to drop quickly. That’s why TIPS researchers are looking for a way
to send the human body into a state of suspended animation, essentially
“shutting down” the heart and brain until proper care can be administered.
Cagrnd squirrel. Photo: wired.comTo understand the mechanics
of hibernation, researchers have turned to squirrels. During the winter months,
squirrels go through an amazing metamorphosis: their 300 beat-per-minute heart
rate slows to a mere two to ten beats, their oxygen consumption drops to
one-fiftieth of normal, and their body temperatures fall essentially to zero.
And yet they emerge from hibernation no worse for wear.
One Stanford University project (also funded by DARPA) tried
using a pancreatic enzyme found in both species to put humans into a state of
squirrel-like hibernation, and another used hydrogen sulfide to stop wounds
from bleeding by stopping heart function in rats and worms. Stanford’s Craig
Heller discovered how squirrels and other hibernators manage to regulate their
core body temperatures, even as they become zombie-like. Those trials lead to
an examination of the human temperature-control system, which led to a
specialized glove-like device, built for the military.
Cheng Chi Lee, an associate professor of biochemistry and
molecular biology at the University of Texas Medical School at Houston,
discovered that the 5-prime adenosine monophosphate (5’-AMP) molecule can
induce a short hibernation-like state in mammals (such as humans) that don’t
normally hibernate. He’s now trying to find ways to maintain that state long
enough to perform major, live-saving surgeries.
Turning pigs into “zombies” could mean the difference
between life and death for wounded soldiers on the battlefield.
According to the Cybercast News Service, when an animal
hibernates, its cells are deprived of the oxygen it receives during its waking
hours. The cells can better endure this low-oxygen state when the animal
reaches a state of hypothermia and its metabolism slows. Similarly, a heart
attack or stroke starves organs of oxygen. According to Dr. Lee, physicians
have long been using cooling procedures to help human cells survive these
conditions.
“If you follow the ambulance services now in response to
heart attack — the first response when you reach a heart attack patient is to
bring the body temperature down as quickly as possible while the patient is
being transported to the hospital,” says Lee. “If you cool the body temperature
down, then you expand the window of preventing ischemia [oxygen-shortage]
damage. It’s really simple, because if the cell is cooled, it needs less
oxygen.”
Lee said the same principle applies to organ transplants.
When the organ donor and recipient live in different parts of the country, the
organ is preserved in an ice cooler or other refrigeration system during
transport.
Medevac helicopter. Photo: popsci.comMore recently, a
US-Chinese team of researchers has identified differences in expression levels
between proteins and messenger RNA (mRNA) between hibernating and
non-hibernating arctic squirrels, suggesting “substantial post-transcriptional
regulation of proteins during torpor-arousal cycles of hibernation.”
The study, published in a recent issue of the ProteoMonitor,
asserts that hibernation “involves complex mechanisms of metabolic
reprogramming and tissue protection.” Previous studies looked primarily into
changes at the mRNA level. The newly published study identifies “significant
differences” in mRNA levels in hibernating and non-hibernating ground squirrels
— the transcripts of mRNA “are protected while translation is inhibited during
torpor. Therefore protein variety and abundance can be very different from
corresponding gene expression at the mRNA level, and differential protein
expression may more directly reflect regulatory changes related to
hibernation.”
A form of squirrel-like hypersleep-hibernation would help
solve a great many of the problems involved in sending humans interstellar
distances. And metabolic and genetic research is zeroing in on what makes
squirrels tick. But more immediately, turning pigs into “zombies” could mean
the difference between life and death for wounded soldiers on the battlefield.
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Appendix C
Orally active
epoxyeicosatrienoic Acid analog attenuates kidney injury in hypertensive dahl
salt-sensitive rat.
Source
Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee,
WI 53226. jdimig@mcw.edu.
Abstract
Salt-sensitive
hypertension leads to kidney injury. The Dahl salt-sensitive hypertensive rat
(Dahl SS) is a model of salt-sensitive hypertension and progressive kidney
injury. The current set of experimental studies evaluated the kidney protective
potential of a novel epoxyeicosatrienoic acid analog (EET-B) in Dahl SS
hypertension. Dahl SS rats receiving high-salt diet were treated with EET-B (10
mg/kg per day) or vehicle in drinking water for 14 days. Urine, plasma, and
tissue samples were collected at the end of the treatment protocol to assess
kidney injury, oxidative stress, inflammation, and endoplasmic reticulum
stress. EET-B treatment in Dahl SS rats markedly reduced urinary albumin and
nephrin excretion by 60% to 75% along with 30% to 60% reductions in glomerular
injury, intratubular cast formation, and kidney fibrosis without affecting
blood pressure. In Dahl SS rats, EET-B treatment further caused marked
reduction in oxidative stress with 25% to 30% decrease in kidney
malondialdehyde content along with 42% increase of nitrate/nitrite and a 40%
reduction of 8-isoprostane. EET-B treatment reduced urinary monocyte
chemoattractant protein-1 by 50% along with a 40% reduction in macrophage
infiltration in the kidney. Treatment with EET-B markedly reduced renal
endoplasmic reticulum stress in Dahl SS rats with reduction in the kidney mRNA
expressions and immunoreactivity of glucose regulatory protein 78 and C/EBP
homologous protein. In summary, these experimental findings reveal that EET-B
provides kidney protection in Dahl SS rats by reducing oxidative stress,
inflammation, and endoplasmic reticulum stress, and this protection was
independent of reducing blood pressure.
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Appendix D
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Appendix E
Main article: Essential fatty acid#Essentiality
Arachidonic acid in the
human body usually comes from dietary animal sources—meat, eggs, dairy—or is
synthesized from linoleic acid.
Arachidonic acid is not one of the essential fatty acids. However, it does become
essential if there is a deficiency in linoleic acid or
if there is an inability to convert linoleic acid to arachidonic acid, which is
required by most mammals. Some mammals lack the ability to—or have a very
limited capacity to—convert linoleic acid into arachidonic acid, making it an
essential part of their diets. Since little or no arachidonic acid is found in
common plants, such animals are obligate carnivores;
the cat is a common example.[4][5] A
commercial source of arachidonic acid has been derived, however, from the
fungus Mortierella alpina.[6]
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