28 Dec 2014
Endogenous H2S increases lifespan .
1.H2S is back !
H2S and the molecular mechanics of freezing metabolisms .
See Appendix A below for latest findings . Endogenous H2S creation increases lifespan . A sort of fast hibernation .
2.Why endogenous H2S?
Safety switch . Organisms without it simply goes into hibernation at the first volcanic eruption , and gets eaten by those with the safety switch .
3. How it works .
(1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S. We also show that physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and facilitate the induction of hippocampal long-term potentiation. These observations suggest that endogenous H2S functions as a neuromodulator in the brain.
4.Also the general metabolism .
This gives all the foods to avoid .
CBS activator, S-adenosyl-L-methionine, enhances H2S production
5.Fasting every third day will then work . But stop MSM addititives during fasting.
6. Intermittent fasting
Eat your heart out .
Molecular mechanism behind health benefits of dietary restriction identified
Increasing endogenous hydrogen sulfide production during dietary restriction plays a major role in delivering the benefits of longevity and stress resistance.
Credit: Image courtesy of Harvard School of Public Health
A new study led by Harvard School of Public Health (HSPH) researchers identifies a key molecular mechanism behind the health benefits of dietary restriction, or reduced food intake without malnutrition. Also known as calorie restriction, dietary restriction is best known for its ability to slow aging in laboratory animals. The findings here show that restricting two amino acids, methionine and cysteine, results in increased hydrogen sulfide (H2S) production and protection against ischemia reperfusion injury, damage to tissue that occurs following the interruption of blood flow as during organ transplantation and stroke. Increased H2S production upon dietary restriction was also associated with lifespan extension in worms, flies, and yeast.
Although H2S gas is extremely toxic in high amounts, low levels present in naturally occurring sulfur springs have long been associated with health benefits. Mammalian cells also produce low levels of H2S, but this is the first time that this molecule has been linked directly to the health benefits of dietary restriction.
"This finding suggests that H2S is one of the key molecules responsible for the benefits of dietary restriction in mammals and lower organisms as well," said senior author James Mitchell, associate professor of genetics and complex diseases. "While more experiments are required to understand how H2S exerts its beneficial effects, it does give us a new perspective on which molecular players to target therapeutically in our efforts to combat human disease and aging."
The study appears online December 23, 2014 in Cell.
Dietary restriction is a type of intervention that can include reduced overall food intake, decreased consumption of particular macronutrients such as protein, or intermittent bouts of fasting. It is known to have beneficial health effects, including protection from tissue injury and improved metabolism. It has also been shown to extend the lifespan of multiple model organisms, ranging from yeast to primates. The molecular explanations for these effects are not completely understood, but were thought to require protective antioxidant responses activated by the mild oxidative stress caused by dietary restriction itself.
First author Christopher Hine, research fellow in the Department of Genetics and Complex Diseases, and colleagues demonstrated that one week of dietary restriction increased antioxidant responses and protected mice from liver ischemia reperfusion injury, but surprisingly, this protective effect was intact even in animals that could not mount such an antioxidant response. Instead, the researchers found that the protection required increased production of H2S, which occurred upon reduction of dietary intake of the two sulfur-containing amino acids, methionine and cysteine. When the diet was supplemented with these two amino acids, increased H2S production and dietary restriction benefits were both lost.
The investigators also found that genes involved in H2S production were also required for longevity benefits of dietary restriction in other organisms, including yeast, worms, and flies.
"These findings give us a better understanding of how dietary interventions extend lifespan and protect against injury. More immediately, they could have important implications for what to eat and not to eat before a planned acute stress like surgery, when the risk of ischemic injury can be relatively high," said Hine.
- Christopher Hine, Eylul Harputlugil, Yue Zhang, Christoph Ruckenstuhl, Byung Cheon Lee, Lear Brace, Alban Longchamp, Jose H. Treviño-Villarreal, Pedro Mejia, C. Keith Ozaki, Rui Wang, Vadim N. Gladyshev, Frank Madeo, William B. Mair, James R. Mitchell. Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits. Cell, 2014; DOI: 10.1016/j.cell.2014.11.048
Compliments of the season to all.