Birdflu Survival Update -4

Birdflu Survival Update -4

Dated 28/10/2005

Some biochemistry from an evolutionary perspective.
Evolutionary principles:
A Things go from simpler to complex.
B Repetition of coding DNA sequences

This results in conversion of digital DNA to analog concentrations of chemicals . This is a DNA favourite , as it easily happens that portions of the DNA is replicated . Eg CTG might be favourable , but CTG CTG CTG even more so . The rest is straightforward survival of the fittest .

The result is that the system is very conservative . The simpler molecules get used first . More fine-tuned control mechanisms evolve by using the intermediary steps in the more primitive chain as controls in their own right . The hormone system in mammals is a good example . Eg Many essential hormones used to be intermediary steps in the synthesis of oestrogen . The same effect can be seen in vitamins .


What has this to do with flu?

The flu virus penetrates the cell-wall by using a protein called neuraminidase , which dissolves the cell-wall . Once inside , the virus replicates . But it then has to get out again . Tamiflu (Oseltamivir) inhibits the secondary formation of neuraminidase after infection of the cell . The propagation of the infection is inhibited , as the infectious DNA is imprisoned by the cell-wall .

Neuraminidase interacts strongly with a simple benzene-type chemical called Resorcinol . This reaction is so strong that it is used as a marker for experimenters .

There is a whole family of simple benzene-type chemicals associated with Resorcinol

Known ones:
Shikimic acid ( pathways lead to salicylic acid , acetylsalicylic acid(aspirin) , methyl salicilate (oil of wintergreen) , tyrosine , vanillin (vanilla) , essential fatty acids , prostaglandins , anti-biotics like erythromycin , tetracyclines , doxordibicin , tamiflu)

Important study :
http://www.ncbi.nlm.nih.gov/entrez
Search for “Catalytic properties of neuraminidase of non-cholera vibrios” by Lavrovskii and Berzov .
Quote:
“…activation of neuraminidase was found in the presence of bivalent metal ions , especially Ca2+ , while chelate-forming complexes and heavy metal salts inhibited the enzyme .”



Pulling it all together:

1 There is interaction between Shikimic derivatives : a very proven one is aspirin and prostaglins . The very simplicity of the molecular structures strongly suggest that there are no energy-humps needing high-energy synthesis or enzymatic intermediation .
( In other words , I suspect that the supposed difficulties in synthesizing Tamiflu are a deliberate attempt to complexify a simple process in order to maximize profits.)

2 Skin and Cell-walls
From the general evolutionary principles above , one would expect that skin-structures would evolve out of cell-wall structures . Why reinvent the wheel ?

3 One would then expect that things affecting the skin would affect cellular walls
Resorcinol , salicylic acid , acetylsalicylic acid and oil of wintergreen are used for “acne,warts,dandruff ,psoriasis and similar conditions”

4 Sulfur
As sulfur is vital to the scaffolding of any cell , it is used as an adjunct in any of the above treatments . The sulfur serves to prevent inhibition of recovery . Think about this carefully .
Human burial practices sequester the large amount of biologically active sulfur away from the recycling process . A serious sulfur deficit is building up . Six billion people , each having about 15 kg of sulfur in their bodies , represents goodly fraction of the available sulfur-biomass . Add the lot in the cemeteries and any large-scale reforestation will create a significant health risk .

5 Arteries and veins.
Inside-out skin . The evolutionary ancestry is the same . The environment interacts in the lungs/gills .
Arterial callus equivalents are called plaque. Note the effect of aspirin .

6 Outside skin
The outside skin is connected to the inside-skin : ie lungs , nose , mouth ,stomach intestines , bladder , kidneys all have direct contact with the outside world and can be considered as one surface . So , for instance , what soap you use influences the micro-ecology of bacteria on your skin and eventually your resistance to disease or digestion Families have their own unique cultures of bacteria and yeasts on their skins . Communal baths (without bactericides) creates a monoculture of skin ecology which can severely compromise immune systems , especially without sufficient sulfur . The medieval decline of communal baths was a logical response . Note that communal baths have not revived . (LA proves the point.) . Japan avoided the worst by keeping it small and class-dependant .

7 What to do
From the suspicion that there is no natural energy hump between Shikimic derivatives (see para 1 above) , the direction of chemical reactions can be driven by concentrations . To be more exact , enhancing the concentration of a derivative can flow-back to the precursor and spill over into other derivatives .There is a back-pressure .

7 ; 1 Raise the temperature : the flu virus does not do so well at temperatures above 104 F . Pulse breathe 105F steam at 5 minute intervals for about half an hour , rest for about 2 hours . Repeat . Adding vanilla won’t hurt . The 5 minutes comes from the potentiating interval needed for a neuron to lay down long-term learning . The logic is that it must have some deep significance in the immune system ( which is , after all , only a glorified school .)

7 ; 1 ;2 : Alter oxidation patterns over longer terms than breathing
The Oxygen and CO2 levels are also dependant on the breathing pattern .
Pulsing the concentration of O2/CO2 over a longer period than the normal breathing influences small organisms faster than larger organisms . This differential can be exploited . (Cf Yoga)

7 ; 2 Add H2S : Suspended animation : About 80 ppm of H2S activates some very old genes that suspends animation at a molecular level ( see below) .

Wear goggles . (See dosages)

Pulsing the concentration of H2S between zero and 80 ppm will incapacitate (suspend biological activity) in small organisms faster than in larger organisms . This differential can be exploited .

I suspect that the normal immune system can handle a lot of insults given this advantage .

It should also help a lot with auto-immune diseases , as each pulse forces the immune system to differentiate between elements it did not think worthy of differentiating before . Neat .

Even neater if the ageing apoptosis mechanisms can be confused .


Suspended Animation (the real thing!)
In 2005, Mark Roth and other scientists from the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle demonstrated that mice can be put into a state of suspended animation by applying a low dosage of hydrogen sulfide (80 ppm H2S) in the air. The breathing rate of the animals sank from 120 to 10 breaths per minute and their temperature fell from 37 °C to 2 °C above ambient temperature (in effect, they had become cold-blooded). The mice survived this procedure for 6 hours and afterwards showed no negative health consequences.
Such a hibernation occurs naturally in many mammals and also in toads, but not in mice. (Mice can fall into a state called clinical torpor when food shortage occurs). If the H2S-induced hibernation can be made to work in humans, it could be useful in the emergency management of severely injured patients, and in the conservation of donated organs.
As mentioned above, hydrogen sulfide binds to cytochrome oxidase and thereby prevents oxygen from binding, which apparently leads to the dramatic slowdown of metabolism. Animals and humans naturally produce some hydrogen sulfide in their body; researchers have proposed that the gas is used to regulate metabolic activity and body temperature, which would explain the above findings
Dosages of H2S:
Treatment involves immediate inhalation of amyl nitrite, injections of sodium nitrite, inhalation of pure oxygen, administration of bronchodilators to overcome eventual bronchospasm, and in some cases hyperbaric oxygen therapy.
Exposure to lower concentrations can result in eye irritation (because of the high alkality of the SH- anion), a sore throat and cough, shortness of breath, and fluid in the lungs. These symptoms usually go away in a few weeks. Long-term, low-level exposure may result in fatigue, loss of appetite, headaches, irritability, poor memory, and dizziness. Higher concentrations of 700-800 ppm tend to be fatal.
· 0.0047 ppm is the recognition threshold, the concentration at which 50% of humans can detect the characteristic rotten egg odor of hydrogen sulfide [2]
· 10-20 ppm is the borderline concentration for eye irritation.
· 50-100 ppm leads to eye damage.
· At 150-250 ppm the olfactory nerve is paralyzed after a few inhalations, and the sense of smell disappears, often together with awareness of danger,
· 320-530 ppm leads to pulmonary edema with the possibility of death.
· 530-1000 ppm causes strong stimulation of the central nervous system and rapid breathing, leading to loss of breathing;
o 800 ppm is the lethal concentration for 50% of humans for 5 minutes exposition (LC50).
Concentrations over 1000 ppm cause immediate collapse with loss of breathing, even after inhalation of a single breath.

7 ;3 Mega-doses of aspirin should lead to an increase in natural neuraminidase inhibitors . Be careful about side-effects (ulcers , blood-clotting). I cannot find anything on the net . Johan , Eben – your bailiwick .

7 ; 4 Take high Vit C doses ( 3-4 grams /day) As per Linus Pauling. Be careful about ulcers Use buffered preparations .

7 ; 5 Take MSM : about 3 grams a day. (Biologically active sulfur) . Vit C speeds uptake .

7 ; 6 Replace skin cultures : wash in a bacteriocidal soap . Then smear a yoghurt with live cultures all over you . Wait about 10 minutes , rinse and dry . Repeat daily for about 3 weeks . Any probiotic culture can be used instead of live yoghurt. The idea is to shift the skin ecology in the direction of symbiotic organisms , instead of the random guerilla skin our society encourages .

7 ; 7 Take tyrosine. .(Back pressure)

7 ; 8 Eat vanilla flavours.(Back pressure)

7 ; 9 Smell vanilla . .(Back pressure)

7 ; 10 Take erythromycin , tetracycline , doxorubicin. .(Back pressure)

I would really like some feedback on items 7;2 , 7;3 .

Andre Willers