Controlled Death Markers .

Controlled Death Markers .
Andre Willers
21 Nov 2011

Synopsis :
Platelets . Beautiful ! Fragments of Destruction evolved into Fragments of Survival .

Discussion :
When cells are destroyed , fragments remain . Systems that recognise these fragments as warning signals survive better .

Why wait until destruction occurs ?
Systems that deliberately create fragments will survive better . Contingency plans .

Enter platelets , Megakaryocytes and cytokines .

http://en.wikipedia.org/wiki/Megakaryocytes
Megakaryocytes create platelets , these platelets being generalised fragments of destruction .
Not all fits , so specialised proteins ( ie C3) have evolved as a next step to tie the platelets to specific bacteria .
Note that C3 evolved as part of the innate immune system .
We therefore strongly suspect that there are chaperones steering C3 and others to mark unknown objects for further attention .

These are then presented to the dentritic immune cells for incorporation into the Learned Immune Response system .

A nifty piece of work .
The innate immune system is incorporated into the learned immune system via the platelets .
The very large search space can be spanned by a small variable space .
The order is of 3 (ie 10^3) . Typical Genetic algorithm .

http://en.wikipedia.org/wiki/Complement_component_3
Complement component 3, often simply calledC3, is a protein of the immune system. It plays a central role in the complement system and contributes to innate immunity. In humans it is encoded on chromosome 19 by a gene calledC3.[1][2]

Instant death :
Looking at the molecular structure of C3 and the clotting factors , we notice an old friend : tell me three times . ( But beware of the Boojum)

There are three locks in the folds of the molecules . Biological systems that utilize only one or two locks will have to be kept in quarantine (ie bi- or tri-poisons in component form .) Not normally found in evolutionary systems .
It would make a nifty exterminator for sexual species . Tie two forms to the X-chromosome and one to the Y-chromosome , and the resultant combination will kill both copulators in an ecstasy of clotting ( literally if we connect an endorphin producing alkaloid) .

Can this evolve ?
Yes , in social species . Already has . See large percentage of neuters in insect species .
This would be driven by overpopulation .
“One Queen in darkness , to rule them all” , with apologies to Tolkien .
This limits population growth to non-exponential terms .


This leads to a delicious anti-bug strategy :
Make them implode .

Hyper Death Markers .
An extremely high concentration of cell-wall fragments .
We have it already in a mild form : petroleum jellies . (Burns)
(Petroleum is formed from destroyed cells)
Low-temperature , low-temperature refined petroleum concentrated in a small volume should trigger cellular implosion (or kill you quickly)

The Spleen :
Unlearning things .
This is where you Unlearn things at a molecular level .
At the stomach level .
Note the tie to the amygdala .
One third of the activated platelets end up in the spleen . As expected . This is the Reserve .
See http://andreswhy.blogspot.com “New Tools” , Nov 2008
But note the Megakaryocyte's DNA nuclei end up in the lungs .Why ?
Note the hypersensitivity of the lungs to rubbish . They have not unlearned some things .

There seems to be link between the spleen and the lung's immune responses (ie asthma ,etc)
But there is little on the Net about reprogramming the Learned Immune System via the spleen , though it is built-in .

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How to Reprogram the Learned Immune Response system :
This is not medical advice . Consult your doctor .

Pulse system :
1.Take about 2000 micrograms of vit B12 . (a hefty dose)
2.Dissolve about 15 gm(3 tsp) of honey (or bee-balm) in a boiling bit of water .
Inhale the fumes after step 3 .
3.Eat about 5 mg (1 tsp) of honey or bee-balm .(1/3)
4.Then continue for at least 5 breaths .

What is supposed to happen : the contrast in the lack of death markers from the honey in the lungs and the spleen , combined with the Vit B12 pulse reprograms the immune responses . If it works , it should help with asthma and diabetes II .
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Death and Broadband :
All organisms with telomeres live longer in the presence of pervasive patterned electro-magnetic radiation .

Delicious !
All those radio towers make you live longer . (Unless you are too close) . Correlate it .

Logic:
The telomere DNA sequence is very specific . Large scale random EM radiation will give rise to stochastic resonance , reinforcing the integrity of the telomere DNA sequence . A longer life .
Feedback systems are involved .

Forced evolution :
This can be done by hiking the patterns to higher Beth(x) levels .

But watch out for the discontinuities in the Fourier series .

Shock systems .
In an emergency , simply use plain dissolved sugar as an inhalant . Does this really work ?
I don't know . Try it .

Diabetics :
1.Three teaspoons of sugar dissolved in a little bit of boiling water
2.One teaspoon of sugar eaten
3.Inhale the fumes from the boiling sugar water .

This should reprogram the spleen to some degree.

Now you know as much as I do.

Unlearning the wrong things is yuck .

Andre
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