Thursday, March 26, 2015

Singularity by 2020 .

Singularity by 2020 AD

Andre Willers
26 Mar 2015
Synopsis :
A New Paradigm in 3D continuous, fast printing enables intelligence expansion in a positive feedback armsrace .

Discussion :
1.Braincells transplant within 2 years  :
2.Force grown clones : see Appendix A and Appendix C
3.Integration of cloned 3 D printed braincells : already done .

4.Psychological integration : blueprint and therapeutic experience exists : the brain transformation at human puberty .
Implanting extra brain cell centers will be an equivalent . SuperTeachers will be needed .

5.See on natural IQ resting ledges calculated ab-initio .
There are hints of groups of very smart people clustered around these ledges that might give sound advice if they can be coaxed out of hiding . Unfortunately , that is unlikely . They saw what happened to previous groups of self proclaimed supermen :
Spartans(exterminated) , Jews(persecuted , nearly exterminated) , Nazis (exterminated) , Tutsi’s(nearly exterminated) , Albigensians(exterminated) , etc ,etc , etc .

7.Does increasing smartness increase the mass of the soul ?
From complexity , it seems that it does .
A runaway intelligence driven Singularity will change the local space-time structures very quickly .Norms would probably not survive it unprotected .

8.Estimate of the size of the human soul (80 t0 400 meters) . A bit of a surprize .

9.Smart Grey Goo
At a sufficiently high intelligence , the lower intelligence is simply regarded as raw material .
For example , humans-bacteria , humans-worms , etc . What to the norm human appears as Grey Goo , is simply healthy growing computronium .

10.Internally controllable nanofactories .
These are being made now .
All you need is one prototype that can replicate itself , and it’s Smart Grey Goo wherever you look .
Optogenetic sensors emit light in response to neuronal signals, such as synaptic impulses or action potentials. These sensor proteins make activity visible. Optogenetic actuators absorb light and cause changes in neuronal signals, such as ionic currents. These acutuator proteins make activity controllable.
This will make the body completely controllable from the inside or the outside . The terms will become meaningless .
A human might decide to keep some organs in gaseous form .
A number of extra , specially created epidermis layers as protection and distant warning systems are probably already in the military pipeline . Armour that concentrates only at the impact point of the bullet has already been patented
Not to mention fashion . Manufacture new styles as you walk .
Why walk ? You could slither , ooze , hop , even roll .

11.Created memories , beliefs and emotions .
See Appendix C below .
The 5 000% increase in effectiveness of breaching the BloodBrainBarrier , as well as other cell walls will save many lives .
Eg a antirabies patch kept in an emergency kit ,  can be slapped on after a suspected bite and still have 90%+ cure probability.
Oxytocin delivery can be made precise and in large doses inside the BBB .
Why bother with insulin receptors?  Make your own receptor site .Use Sodium Formate (E-237)  more commonly used as a food preservative.
The same for addictions involving decrease in number of receptors .
11.1 Drawbacks
False memories , beliefs , desires , emotions , compulsions , etc can be induced by aerosol , touch , patch .
A real , working love-perfume can be made . Oxytocin +Sodium Formate and a bit of tinkering .
Not to speak of politicians , con artists , teenagers , criminals , etc .

11.2 This will necessitate an armsrace .
The resultant entity will not be regarded as human by Human(Norm)
Being at ground zero of a megaton explosion (10^15 J) will just add to the charge in his batteries .
The end of Human(norm) except for zoos and control groups by 2020 AD at the latest .

About time .
The end of the obscene Anthropocene .
Enter the Novocene . Where every pattern is new because it is unique .
Have fun !

Appendix BB
Singularity within five years
Andre Willers
24 mar 2015

Revolutionary 3-D printing technology uses light and oxygen to synthesize materials from a pool of liquid – ScienceDaily
See Appendix A

A major paradigm shift in mass production speeds , costs , accuracy and novel applications .

Grey Goo becomes a possibility .

This tech Clip uses light and oxygen.
Note the light controls under direct nerve control used presently in mind-computer interfaces and switching of gene on-off controls .

The 3D printing of an organism clone should be able to be done in a matter of hours .
The latest time estimate for a brain transplant is now 2 years .

As well as increasing computing power of person by simply adding more cells .

Struldbugs rule , ok.

Singularity is now at most 5 years in future .




Appendix A
Revolutionary 3-D printing technology uses light and oxygen to synthesize materials from a pool of liquid

New 3-D technology uses light and oxygen to fuse objects allowing for very quick accurate 3-D printing.
Credit: Screen shot from provided video, courtesy of Carbon3D Inc.
A 3D printing technology developed by Silicon Valley startup, Carbon3D Inc., enables objects to rise from a liquid media continuously rather than being built layer by layer as they have been for the past 25 years, representing a fundamentally new approach to 3D printing. The technology, to appear as the cover article in the March 20 print issue of Science, allows ready-to-use products to be made 25 to 100 times faster than other methods and creates previously unachievable geometries that open opportunities for innovation not only in health care and medicine, but also in other major industries such as automotive and aviation.
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Joseph M. DeSimone, professor of chemistry at UNC-Chapel Hill and of chemical engineering at N.C. State, is currently CEO of Carbon3D where he co-invented the method with colleagues Alex Ermoshkin, chief technology officer at Carbon 3D and Edward T. Samulski, also professor of chemistry at UNC. Currently on sabbatical from the University, DeSimone has focused on bringing the technology to market, while also creating new opportunities for graduate students to use the technique for research in materials science and drug delivery at UNC and NCSU.
The technology, called CLIP -- for Continuous Liquid Interface Production -- manipulates light and oxygen to fuse objects in liquid media, creating the first 3D printing process that uses tunable photochemistry instead of the layer-by-layer approach that has defined the technology for decades. It works by projecting beams of light through an oxygen-permeable window into a liquid resin. Working in tandem, light and oxygen control the solidification of the resin, creating commercially viable objects that can have feature sizes below 20 microns, or less than one-quarter of the width of a piece of paper.
"By rethinking the whole approach to 3D printing, and the chemistry and physics behind the process, we have developed a new technology that can create parts radically faster than traditional technologies by essentially 'growing' them in a pool of liquid," said DeSimone, who revealed the technology at a TED talk on March 16 in the opening session of the conference in Vancouver, British Columbia.
Through a sponsored research agreement between UNC-Chapel Hill and Carbon 3D, the team is currently pursuing advances to the technology, as well as new materials that are compatible with it. CLIP enables a very wide range of material to be used to make 3D parts with novel properties, including elastomers, silicones, nylon-like materials, ceramics and biodegradable materials. The technique itself provides a blueprint for synthesizing novel materials that can further research in materials science.
Rima Janusziewicz and Ashley R. Johnson, graduate students in DeSimone's academic lab, are co-authors on the paper and are working on novel applications in drug delivery and other areas.
"In addition to using new materials, CLIP can allow us to make stronger objects with unique geometries that other techniques cannot achieve, such as cardiac stents personally tailored to meet the needs of a specific patient," said DeSimone. "Since CLIP facilitates 3D polymeric object fabrication in a matter of minutes instead of hours or days, it would not be impossible within coming years to enable personalized coronary stents, dental implants or prosthetics to be 3D printed on-demand in a medical setting."
CLIP's debut coincides with the United Nation designating 2015 as the International Year of Light and Light-Based Technologies, which recognizes important anniversaries of scientific advances enabled with light.

Story Source:
The above story is based on materials provided by University of North Carolina at Chapel Hill. The original article was written by Thania Benios, Office of Communications and Public Affairs; and Crista Farrell, Research Group of Prof. Joseph DeSimone, Department of Chemistry and Lineberger Comprehensive Cancer Center. Note: Materials may be edited for content and length.

Journal Reference:
1.             J. R. Tumbleston, D. Shirvanyants, N. Ermoshkin, R. Janusziewicz, A. R. Johnson, D. Kelly, K. Chen, R. Pinschmidt, J. P. Rolland, A. Ermoshkin, E. T. Samulski, J. M. DeSimone. Continuous liquid interface production of 3D objectsScience, 2015; DOI: 10.1126/science.aaa2397

Appendix C
Speeding up BloodBrainBarrier penetration (or any cell barrier) by a factor of 50 (5 000%) . Already done .

Stinging nettle chemical improves cancer drug
Researchers at the University of Warwick found that when the chemical, Sodium Formate, is used in combination with a metal-based cancer treatment it can greatly increase its ability to shut down cancer cells.
Developed by Warwick's Department of Chemistry, the drug, a compound of the metal ruthenium called JS07, is capable of exploiting a cancer cell's natural weaknesses and disrupts its energy generation mechanism.
Laboratory tests on ovarian cancer cells have shown that when used in combination with Sodium Formate JS07 is 50 times more effective than when acting alone.
Derived from formic acid which is commonly found in a number of natural organisms including nettles and ants, Sodium Formate (E-237) is more commonly used as a food preservative. The Warwick researchers developed a novel method for binding Sodium Formate with JS07 to form a more potent form of the drug.
The researchers subsequently found that the potent form of JS07 acts as a catalyst when it interacts with a cancer cell's energy-generating mechanism. This interaction disrupts the mechanism, causing the cell's vital processes to cease functioning and for the cell to shut down.
Lead-researcher Professor Peter Sadler explains:
"Cancer cells require a complex balance of processes to survive. When this balance is disrupted the cell is unable to function due to a range of process failures and eventually shuts down. The potent form of JS07 has proven to be very successful when tested on ovarian cancer cells."
The combination of Sodium Formate and JS07 provides a number of potential benefits to cancer patients, including a reduction in the negative side-effects compared with other traditional cancer treatments:
"By itself, JS07 is capable of shutting down cancer cells but when used in combination with Sodium Formate this ability is significantly increased. As a result, lower doses would be required to target cancer cells -- reducing both the drug's toxicity and potential side-effects.," says Professor Sadler.
A further benefit is that once the potent form of JS07 has interacted with a cell's energy generation mechanism the remaining non-potent JS07 molecules can then be reused in combination with a fresh supply of Sodium Formate.
"When the potent form of JS07 interacts with a cell's energy generation mechanism, the Sodium Formate is used up in the process, but the JS07 itself is still viable to be used again. When it comes into contact with fresh supply of Sodium Formate it can again become potent, making this an efficient potential treatment."
The research could also lead to substantial improvements in cancer survival rates. Co-researcher Dr Romero-Canelon says:
"Current statistics indicate that one in every three people will develop some kind of cancer during their life time, moreover approximately one woman dies of ovarian cancer every two hours in the UK according to Cancer Research UK. It is clear that a new generation of drugs is necessary to save more lives and our research points to a highly effective way of defeating cancerous cells"
The research, Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design, is published by Nature Communications.
·  Joan J. Soldevila-Barreda, Isolda Romero-Canel√≥n, Abraha Habtemariam & Peter J. Sadler. Transfer hydrogenation catalysis in cells as a new approach to anticancer drug designNature Communications, March 2015 DOI: 10.1038/ncomms7582


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