10 March 2007
All spices are potent killers evolved by plants to control viruses , fungi , bacteria , insects , animals in descending order of importance .
Multi-symbionts ( like large mammals , including humans ) , use small concentrations of spices to keep various populations of symbiotic bacteria and fungi under control .
Highly active bio-reactors like the tropics or high-density cities may only be survivable to humans because the use of spices .
The increase of human population in Europe after an increased spice trade with the East circa 18’nth century argues for it . Ref the high incidence of curry and Indonesian dishes in the most highly populated areas of Europe (England and Netherlands) .
With global warming , the spicing of previously temperate regions will continue .
Indeed , those persisting in a non-spice diet will suffer the dreaded Delhi-belly .
The Tao of Curry .
Eat at least one curry a week .
Keep changing and don’t overdo it .
Curcumin ( the active ingredient of turmeric)
There has been a lot of activity in reputable publications and research organizations about this chemical .
See a good summation in the Feb 2007 issue of Scientific American . Google it (there is lot on PubMed)
Apart from its 5000 year history , present studies have shown benefits for :
Anti-cancer ( in low concentrations)
Energy systems (diabetes II)
The plant uses its property of inhibiting protein p53 ( which prevents replication of cancer cells) to kill small mass organisms . If you take too much curcumin , the same will happen to you . About 8 gm per meal (1.5 teaspoonful turmeric ) per meal within 24 hrs seems safe . ( Curcumin is not easily absorbed) .This should be equivalent of about two 500 mg gel capsules of Curcumin by Solal .
Some effects (like the Alzheimer and cognitive improvement) can be traced back to the release of immune system assets to the body because turmeric is killing cells requiring their attention in the gut . In elderly people this extra resource in the immune system is enough for amelioration .
Betterment of Colitis and Rheumatoid Arthritis can be seen as the effect of fluctuations in the gut populations and the concomitant immune-system targeting mechanisms .
See http://andreswhy.blogspot.com “Vaccine”
Energy systems (diabetes II)
Adjuvent effects :
VitC is the main concern . Large doses of VitC (7 to 10 gm range) will kill off so many gut bacteria , that the survivors will be exposed to higher concentrations of curcumin . The leftover spillage might be enough to raise the plasma blood level concentrations to levels that trigger the p53 protein degradation/block . Does it , though? The evidence does not support it . The spillage (diarrhea ) gets washed out . Alcohol and antibiotics will play the same role . The experimental data is on test-tube bacteria , not body cells exposed to the immune system .
Some pathologies (like too high concentrations of p53) prevent replication of necessary systems , especially the immune system . Hence the effect on Alzheimers .
There is no correct concentration for chemicals like these . The best hope is keeping the concentration within an attractor basin .
Ho-ho ! Note Vindaloo guts , long thought to be from the oil . It is actually dead gut bacteria being washed out .
Is it safe to eat curry and drink at the same time ? Stupid question .
Is it safe to eat curry and take antibiotics at the same time ? A mild curry is safest , unless you want to reach some specific group of cells and know what you’re doing .
Statistics on Alzheimers and colon cancers :
The change between actual and expected incidences during the period in which the UK changed over to a curry-loving nation , should be illuminating .
Alzheimers is interesting . Curcumin apparently helps the immune system to attack the amyloid plaques (“Journal of Alzheimers Disease “, Oct 9 2006)
Cognitive Impairment (“American Journal of Epidiomology” , Nov 1 2006)
Curry eaters oldsters were smarter .
One wonders whether Churchill ate curry (Did he? Must have.) Hitler definitely did not .
Still in use :
Peppermint , ginger , garlic , pepper , chili , cinnamon , chocolate , coffee , tea , curries ,etc .
Older ones like
Nutmeg etc . These actually might have had powerful medicinal properties on a virginal viral or bacterial population , but general use would have soon bred resistance (like with antibiotics nowadays) . (Penicillin ? How quaint .)
Viral antibiotics would soon burn out , but the resistance genes would have shifted to the backburner by now . So , in limited usage , they might be of some benefit once again .
Why did garlic not burn out ? Because it only worked well in fresh-pressed form . Most recipes call for worked garlic (oxidized to uselessness.) Buchu has a similar problem .Marketing opportunities .
Energy systems (diabetes II)
Mitochondria are the main energy users in cells . If too much energy (glucose) floods in , the mitochondria can handle it by making more mitochondria or inhibiting the glucose influx through the cell-wall . (The last is DiabetesII)
People with a high metabolic rate must create more mitochondria . But mitochondria are sensitive to p53 (or something like it , since they are descended from bacteria .)
Too much p53 inhibits the formation of new mitochondria , leading to a feedback to the cellwall to prevent a further influx of glucose disrupting the cell .
But mitochondria cannot go cancerous , as they do not have the machinery . The worst that can happen is hyperactivity , as new mitochondria are formed and the ATP has to go somewhere .
Call this Ultra-DiabetesII H (for hyperactivivty . )
This would result from developmental distortion if present throughout childhood .
Unfortunately , the cellular cure would probably cause diabetesII .
Ultra-DiabetesII A :
The mitochondria divide at far too small a pace to keep up with attrition and demand . The feedback is vicious . Also known as Anorexia . A selective p53 inhibiter should help .
What is a poor fatso elderly DiabetesII to do ?
A selective inhibitor of p53 within certain boundaries targeted at human cells should do the trick .
We know that Curcumin is a relatively safe p53 inhibitor , and we have some idea of the concentrations .
We need the raw materials for mitochondria : eg sulfur , selenium , and other rare micro-minerals .
We need energy (glucose and fats) over a certain threshold .
We need some phosphor .(For the ATP)
Note Riboswitches (cf Scientific American Jan 2007 p42) . Bacteria have ribosome switches that control the expression of their own genes dependant on the environment (Aptamers) . These are the progenitors of the more sophisticated epigenetic systems . But for mitochondria they are still operative .
We hope that p53 is the riboswitch to inhibit the inhibition of mitochondria division .
We provide the raw materials for mitochondria divisions .
Mitochondria live for about two days , and should learn the lesson in about 2/e~6 days .
Three repeats should settle the feedback system into a new stability point .
The course lasts 3 treatments (6 days)
In sequential order :
8 gm VitC (buffered)
About two hours later , take
8 gms curcumin ( 4X500 mg Solal Cucrcumin capsules)
Then the adjuvents : multimineral and multivitamins . MSM . Cinnamon capsules .
Glucose : keep it high . drink coke or eat bread .
Repeat every 2 days for 2 repeats .
Symptoms of the treatment:
The mitochondria divide . At first you might feel cold , as millions of mitochondria spend their energy in dividing . Then you will feel hot as sensors in the skin recalibrate . Then you will feel cold again as spillover of p53 inhibitors and other homeostatic systems cause more sweat glands to form . Initially you will sweat more , as too much heat is pumped through too few sweat tubes .
In six days it will be over , hopefully at a higher metabolic rate .
You will feel more active (indeed , you are forced to burn the new ATP , as you cannot any longer store most of it as fat .)
You should use body image sculpting during the 6 day process .
See http://andreswhy.blogspot.com “Human Hair”
DiabetesII take note .
If the procedure is successful , you cannot tell by just doing one glucose test . A full GTT has to be done , and repeated at least two times at weekly intervals .
Changing from lethargic to hyperactive will take some adaptation , but our society and bodies are structured to handle this .
A lethargic body-politic is too close to learned-helplessness .
We can survive any number of competing systems , but we cannot survive one active lot and the rest supine .
Is this spicy enough for you?