Sunday, May 27, 2012

Prions and the Amygdala

Prions and the Amygdala
Andre Willers
27 May 2012
“Tickled to life”
Synopsis :
The amygdala is being reprogrammed by prions . Post-traumatic Stress Disorder , Learned Helplessness and Anxiety interventions are possible via prions .
Discussion :
See “Prions of Immortality” , “Prions and XNA” , “Prions and Autism “ May 2012
Work done by Hariri of duke University and Panksepp of Washington State University shows that emotional states are programmed by selective activation or inactivation of very specific genes .
Panksepp has found 7 basic genetically caused emotional states :
1.Seeking(curiosity) , Play , Care , Lust
2.Fear , Rage , Panic/Grief
Note the balance between positive and negative feedback systems .
The Amygdala :
Fear , Rage , Panic/Grief.
That is its function in enabling the organism to survive . The amygdala has various equivalent sub-structures (called chakras in Eastern systems) , or astrocytes in Western systems . These harbour memories of Bad Things , and triggers behaviours to avoid them . But no “Off” switch .
The “Off” switch or dimmer lies with Seeking(curiosity) , Play , Care , Lust , which are at a deeper level in the structures of the hypothalamus . This is not what I expected .

Tickling .
Delicious !
Tickling should drastically ameliorate Post Traumatic Stress Disorder or Peripheral Neuropathy . Right at the root level . But the tickling must be at an order of randomness (Beth) higher than that of the organism being tickled . No anticipation allowed .
How does it work ? We haul in the usual suspect , the pituitary. This generates the necessary prions . Prion Central . Much more potent than hormones .
It is intimately involved with Prolactin , the mammalian secret weapon . See Appendix I for an abbreviation .
A really potent biochemical positive-feedback chemical rated up there with opiates and oxytocin . (Panksepp) . Notice the close relationship of the physical structure with some prions .
Prolactin in mother’s milk makes you addicted to Mother . Literally and biochemically . Delicious is the inverse stimulation of Prolactin release in the mother caused by suckling . The mother becomes addicted to the child . As I said , the mammalian secret weapon .
Any opiate addiction should then be able to be broken by a combination of oxytocin and prolactin . A more social addiction replaces a harmful one .

Click language .
There is graduated pleasure chirp signal at 50 kHerz amongst rats (Panksepp) as a result of tickling . This is pleasure signal to stand-down stressors . See previous posts on the Click language .
A double teeth click , followed by a double tongue click will give a resonance of it and have some effect . Better yet , simply generate the sound . You can broadcast anti-stress as inaudible background . Supermarkets , armies or emergency organizations note .

Tickling Therapist .
Combine tickling with prolactin , oxytocin and a 50 kH chirp and you can reprogram the various amygdala’s in the body . There is an immune system effect as well . Auto-immune immune systems should ameliorate .
A bit higher tech would be to simply make the relevant prions to manufacture the relevant chemicals . But we are not there yet .
An obvious offspin is regeneration-prions . Or anti-scarring . Or skin-regeneration (cosmetics) . Make the cells love to sacrifice themselves .
You see where apoptosis comes from ?
Apoptosis is not a command , but a seduction . And positive-feedback elements have to be involved .
“Dulce est pro patria mori”
Tickling is more fun .
Appendix I
From Wikipedia, the free encyclopedia
Prolactin (PRL) also known asluteotropic hormone (LTH) is a proteinthat in humans is encoded by the PRLgene.[1]
Prolactin is a peptide hormone discovered by Henry Friesen. Although it is perhaps best known for its role in lactation, prolactin already existed in the oldest known vertebrates—fish—where its most important functions were probably related to control of water and salt balance.
Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system. Prolactin has important cell cycle related functions as a growth-, differentiating- and anti-apoptotic factor. As a growth factor binding to cytokine like receptors it has also profound influence on hematopoiesis,angiogenesis and is involved in the regulation of blood clotting through several pathways. In summary, "more than 300 separate actions of PRL have been reported in various vertebrates, including effects on water and salt balance, growth and development, endocrinology and metabolism, brain and behavior, reproduction, and immune regulation and protection".[2] Prolactin acts in endocrine, autocrine, and paracrine manner through the prolactin receptor and a large number of cytokine receptors.[2]
Pituitary prolactin secretion is regulated byendocrine neurons in the hypothalamus, the most important ones being the neurosecretory tuberoinfundibulum (TIDA) neurons of the arcuate nucleus, which secrete dopamine to act on the dopamine-2 receptors of lactotrophs, causing inhibition of prolactin secretion. Thyrotropin-releasing factor(thyrotropin-releasing hormone) has a stimulatory effect on prolactin release.[not verified in body]
Vasoactive intestinal peptide and peptide histidine isoleucine help to regulate prolactin secretion in humans, but the functions of these hormones in birds can be quite different.[3]
Prolactin is sometimes classified as a gonadotropin[4] although in humans it has only a weak luteotropic effect while the effect of suppressing classical gonadotropic hormones is more important.[5]
Several variants and forms are known per species. Many fishes have variants prolactin A andprolactin B. Most vertebrates including humans also have the closely related somatolactin. In humans 3 smaller (4, 16, and 22 kDa) and several larger (so called big and big-big) variants exist.[not verified in body]

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