Mini-Meiosis and Immortality
15 Mar 2011
Stem-cells are created by mini-meiosis during the cytokineses phase of mitosis .
The triggers are zinc-finger proteins generated by gene Prdm9 .
Read NewScientist 12 Feb 2011 "Evolution's X factor" p33
Essentially , gene Prdm9 denotes and triggers hotspots for chromosome crossover during meiosis by producing zinc-finger proteins .
Crucially , mutations in an intact gene Prdm9 gene (13 letters) only changes the site of the crossover . It is thus immortal , and plays the role of a meta-control .
"Proteus" would be an equally correct name .
During mitosis , mini-meiosis is triggered by the presence of some control , probably zinc-finger proteins . A certain percentage of pluripotent cells are formed but with meiosis-type crossovers of chromosomes on the crossover hotspots as designated by gene Prdm9 . You see what a can of worms it is .
The pluripotent cells are then not copies , but daughters , and should be described as chimaera's .
This gives cells the vitality to compete .
See http://andreswhy.blogspot.com "Ageing" Feb 2011
Engineering zinc-finger proteins to lock on to the Last TTAGGG telomere tag should do the trick . This should result in a pluripotent cell instead of a death .
Immortality of the moving-along sort .
Now you know as much as I do .
Long Life !