Saturday, November 03, 2012

Juggling and Parkinson's Disease II

Juggling and Parkinson’s Disease II
Andre Willers
3 Nov 2012
Synopsis :
Juggling increases brain white-matter (experimental) . The reward mechanism is dopamine . The inhibition of (inhibition of dopamine) is partly governed by ethylene . Plant-whisperers get more organically active ethylene . The two combine in a synergistic way .

Discussion :
Some people have wondered what the connection between juggling and plant whispering is . The connection is dopamine via ethylene and it’s bio-active compounds . Plant-whispering alone will inhibit the inhibition of dopamine-forming , but it is enhanced by some orders of magnitude if juggling is included . Synergism .
You will need the building –blocks of the nervous system like omega-3 oils (flax seed oil) and cod liver oil .
Will a whiff of ethylene help (ie like ripe banana peels) ?
I have no idea . (Personally , I would rather be caught sniffing banana peels than whispering to plants . But maybe it’s just me .)
At least the juggling is recognized .

Juggling and Mirror-neurons
The essence of it .
Juggling forces the growth of new mirror-neuron networks . This can be enhanced by personalizing the juggling objects , with smiles on them . A mature network will recognize them (characters from well-known soapies , etc) . This works at even a single neuron level .
You can make it interactive . Something like WII . I don’t think purely virtual will work . There has to be muscle interaction .
By gad , a new toy ! Juggle your way into the soapies . Lots of money to be made from the old wrinklies .

Sports :
If you star player seems to have hit a plateau , grow some new mirror-neurons by juggling .

Business :
The new executive toy . A multi-tasking trainer that actually works .

Your pleasure centres can juggle things in ways you have not even thought about .

Money :
New mirror-neurons gives you a new perspective .

Old Age:
Boredom is a killer . It is not that there are no new experiences , it is that any experience is translated along old neural paths . So they see only the ho-hum similarities , but not the new experience . For that you need some new pathways . Hence juggling .

Immune system :
The immune system gets bored as well (it is evolutionary programmed in.) It needs both muscle and brain new chemicals to activate new switches in the DNA-Epigenetic system . Unused systems gets apoptized via the epigenetic system .

Music :
Music to juggle by . I do not know of any , but doubtlessly there will soon be some .

What to do ?
1.Start juggling .
2.Take brain food chemicals like Omega fats .
3.Get a plant to whisper to . Your Confessor plant . Make sure it has no microphone in it .

Dopamaniacally yours

Appendix I
Juggling Shown to Change Wiring of the Brain
October 14, 2009 07:00 AM
by Denis Cummings
An Oxford University study has found that practicing a task such as juggling can alter the structure of the brain, indicating that the plasticity of the brain is greater than previously believed.
Juggling Increases White Matter

Researchers tested the brains of 48 volunteers, half of whom were given weekly juggling lessons for six weeks. At the end of that period, their brains were tested again. Those who had juggled—regardless of whether they had become good jugglers—had a 5 percent increase in their brains’ white matter, the nerve strands that connect different parts of the brain. Those who hadn’t juggled had little change.

Previous studies have found that juggling and other mind tasks—such as cabbies memorizing the streets of London—increased the amount of grey matter, the portion of the brain that contains neurons. This is the first study to find that white matter is affected.

Lead researcher Dr. Heidi Johansen-Berg said that the research shows “the structure of the brain is ripe for change.” It raises hope that scientists can design treatments to improve brain function for those with dementia or neurodegenerative diseases such as multiple sclerosis, Alzheimer’s and Parkinson’s.

“Knowing that pathways in the brain can be enhanced may be significant in the long run in coming up with new treatments for neurological diseases, such as multiple sclerosis, where these pathways become degraded,” said Johansen-Berg.
The study, “Training induces changes in white-matter architecture,” is published in Nature Neuroscience.
Appendix II
How to juggle .Note the “Aha!” hurdle . A general empowerment mechanism .
Appendix III
Gravity independent . Note mesons .
Juggling has been performed in space despite the fact that the micro-gravity environment of orbit deprives the juggled objects of the essential ability to fall. This is accomplished through 'two-person' juggling passing multiple objects between them. Juggling in space was demonstrated by Greg Chamitoff andRichard Garriott[citation needed] while Garriott was visiting the International Space Station as aSpaceflight Participant in October 2008. Their juggling of objects while in orbit was featured in 'Apogee of Fear', the first science fiction movie made in space by Garriott and 'Zero-G Magic', a magic show also recorded in space by Chamitoff and Garriott at that time.
Appendix IV
A commercial application of ethylene inhibition of growth hormones , including dopamine .
Dopamine-assisted immobilization of poly(ethylene imine) based polymers for control of cell-surface interactions.
Tsai WB, Chien CY, Thissen H, Lai JY.
Department of Chemical Engineering, National Taiwan University, 1 Roosevelt Road, Section 4, Taipei 106, Taiwan.
Non-fouling coatings play a critical role in many biomedical applications, such as diagnostic assay materials, biosensors, blood contacting devices and other implants. In the present work we have developed a facile, one step deposition method based on dopamine polymerization for preparation of non-fouling and biotinylated surfaces for biomedical applications. Poly(ethylene imine)-graft-poly(ethylene glycol) co-polymer (PEI-g-PEG) was mixed with an alkaline dopamine solution and then deposited onto different substrates. The dopamine coatings formed by this method were characterized by X-ray photoelectron spectroscopy (XPS), and the results indicated successful deposition of PEG. The resultant dopamine coatings formed on tissue culture polystyrene by this method revealed successful deposition of PEG, as shown by XPS. PEI-g-PEG/dopamine deposition for 2h inhibited the adsorption of serum proteins and the attachment of fibroblasts, suggesting that PEG molecules were immobilized in a sufficient density on the surface of the coating. Furthermore, co-deposition of PEI-g-PEG and PEI-g-biotin in alkaline dopamine solutions provided a cell-resisting background surface, at the same time providing accessible biotin molecules. We have demonstrated that the surface can be used for the selective binding of avidin, followed by the binding of Arg-Gly-Asp-Ser-biotin and enhanced cell attachment by specific cell-ligand interactions. In conclusion, our one step immobilization method provides a simple tool to fabricate surfaces with controllable cell affinity.
Copyright © 2011 Acta Materialia Inc. Publishe
Appendix V
The whole previous shebang .
Juggling and Parkinson’s
Andre Willers
29 Oct 2012
Juggling is an ideal counter to early Parkinson’s Disease .

Discussion :
1.The problem is basically caused by the paring of neurons during the menopausal phase of human development . Sedentary persons run into the “Use or lose it” mechanisms . These mechanism are very basic , involving eye-muscle interactions to prevent dopamine apoptosis in seldom-used neurological pathways . Exercise alone is insufficient as it is too predictable .

2. Juggling with asymmetric objects fills the bill nicely . It is chaotically complex , so all the muscle-brain networks are continually used . Start with glass miniature bottles of whisky over a tile floor . The amygdala has to be involved . (Well , maybe over a carpet initially . ) Drink one when an exercise has been done successfully (positive feedback) .
Juggling will help with Restless Leg Syndrome .
3. Advanced students can walk around while juggling .
4.Parkinsonian crash and a Fall .
The neurological effects accumulate slowly , and culminates in a Crash . This is the neurological equivalent of a stroke . Balance is lost after heroic efforts and a heavy fall usually results
The problem is that the feedback to the muscles is too slow –a form of indecision .
. Depression sets in at a neurological level , usually typified by learned helplessness .
This is serious as a broken leg . No amount of “Pull yourself together” etc will not help .

5. Repair .
See Appendix I on how to do this .

The laws of physics impose limits to indecision . Use it or lose it .
7. Old age wisdom
The neurological mechanisms used to translate 2-Dim systems into 3-Dim systems are essential for time-projections . Ie 3-Dim -> 4-Dim structures .

8. Tai-Chi Juggling .
Wait and hurry-up . This lights up just about every mind-body system .
Throwing things about is the frustration of Age .
Catching them is the wisdom of age .

Use it or lose it .


Appendix I
The Plant Whisperer
Andre Willers
28 Oct 2012
Synopsis :
The hot breath (38C) and endogenous ethylene of the Plant Whisperer close to the plant induces hormonal changes in the plant .

Discussion :
Whispering to plants means being up close with your heat and breath . The hot-air envelope surrounding the body encompasses the plant and further concentrates ethylene .
1.Hormonal sensitivity .
Even small concentrations of high temperature right on the leaves (human breath about 1 ppb) will trigger plant reactions .See Appendix II for which reactions .

2.Humans enhance the effect by exposure to sunlight .See Appendix I . Don’t whisper to plants in the dark .

3. Smokers have about double the effect . See Appendix I .

4.Herd effect :
A breath of a herd of herbivores (cows , buffalo , dinosaurs ,etc) will act to synchronize a field .
The plants will release signalling molecules to amplify the effect of the ethylene from the herd’s breath . Maturity and reproduction in synchronization has major evolutionary survival benefits .
Remember the dung . The dung spreads trace elements (especially sulphur from lightning strikes) . The herd animals’ breeding is forced into synchronization with the plants .
A mutual feedback system evolves .

5.The Human Herd :
Each human is a herd of single-celled organisms . Some are more “human” than others . Some are symbiotic , some mutualistic , some commensal and some parasitic .

Just to make things interesting , they can switch roles . They have a large repertoire of roles hidden in the DNA and Epigenetic switches .

But a large number still have plant genes sensitive to ethylene . The strong suspicion arises that the human body uses ethylene to synchronize senescence . At least the mitochondria .
Note the bit about anaerobic conditions inhibiting ethylene formation . Aerobic exercise .

6.Rejuvenation :
We now have three mechanism affecting the whole and parts of the metabolism :
1.Molecular freeze (See Appendix III on hibernation using H2S)
2.Ethylene synchronizing the shebang in whole and parts .
3.Stem cells.
Stem cells are being produced all the time , but forced into age-synchronization by ethylene .

7.The Living forever trick .
We can play them off against each other to selectively synchronize a group of cells iro senescence , then freeze them using the H2S trick , then force neighbouring cells/organs into juvenility using ethylene during the unfreezing .

8.Notice that both H2S and ethylene (C2H4) are very permeable gases . Major players in the early evolution of life .

9. What is a poor man to do ?
All this sounds horribly expensive . Immortality for only the rich ?
What we want to do is to is boost age-synchronization using ethylene , then freeze it using H2S , then re-synchronize the age mechanism on the stem cells . In other words , give the stem cells an overwhelming advantage .

10.The Method:
1.Pre-prepare by taking silver nano particles (See Appendix II :inhibitors . Or wear silver jewelry . )
2.Take a whiff of ethylene . Wait three breaths .
3.Take a whiff of H2S . Wait three breaths .
4.Take a whiff of ethylene . Wait three breaths .
5.Repeat at least once a day.

This should rejuvenate some systems .

11.Why is such a simple system not known ? Because humans fear a lack of death .They are limited by the scope of their environment . Which is one of the reasons I am writing this .Death is only the beginning .

Hope that death is not but a dream .

Appendix I
Human ethylene exhalation.
Release of ethylene in sunlight .
From 1 ppb to about 4 ppb after about 20 minutes .
During lipid peroxidation traces of volatile hydrocarbons such as methane, ethane, ethylene, propane, butane, hexane and pentane are produced in very low concentrations and exhaled through breath and/or released through the skin.
Within 3 min after UV is turned on, the C2H4 emission starts to rise. After UV exposure, a two-phase decay in C2H4 emission was observed: a fast decay resulting from wash out by the lungs and blood and a slow long-term decay from the body tissue.
Body Burden:
Ethylene was detected in the expired air from 2 of 8 volunteers (1 smoker) during a test period of approximately 1 hr at quantities of 120 ug (smoker) and 0.91 ug(1).
[(1) Conkle JP et al; Arch Environ Health 30: 290-5 (1975)]**PEER REVIEWED**

Appendix II
Ethylene as a sensitive plant hormone .
Ethylene is a gaseous effector with a very simple structure. Nonetheless, ethylene has features that identify it as a hormone such as the fact that it is effective at nanomolar concentrations.
BLEECKER A.B. and KENDE H (2000) Ethylene: a gaseous signal molecule in plants. Annu. Rev. Cell Dev. Biol. 16: 1-18 (2000)

Inhibitors are frequently used to study biosynthesis of ethylene and ethylene activity. AVG (aminoethoxyvinylglycine) und AOA (aminooxy-acetic acid) are inhibitors of ethylene biosynthesis. NBD (2, 5-norbornadiene) and Ag+ inhibit an ethylene response by binding to and blocking of the ethylene receptor. NBD is more specific as compared to silver ions.
Ethylene has evolved as the central regulator of cell death programs in plants. In roots and in some plants in stems, lack of oxygen induces formation of intercellular spaces, the so-called aerenchyma. Low oxygen conditions in waterlogged roots, for instance, result in lysogenous aerenchyma formation through programmed death of cells in the cortex. This process is controlled by ethylene, as is programmed death of endosperm cells during cereal seed development.
This reactions is oxygen-dependent. At anaerobic conditions ethylene formation is completely suppressed.
Environmental and biological triggers of ethylene
Environmental cues can induce the biosynthesis of the plant hormone. Flooding, drought, chilling, wounding, and pathogen attack can induce ethylene formation in the plant. In flooding, root suffers from lack of oxygen, or anoxia, which leads to the synthesis of 1-aminocyclopropane-1-carboxylic acid (ACC). ACC is transported upwards in the plant and then oxidized in leaves. The product, the ethylene causes epinasty of the leaves.
One speculation recently put forth for epinasty is the downward pointing leaves may act as pump handles in the wind. The ethylene may or may not additionally induce the growth of a valve in thexylem, but the idea would be that the plant would harness the power of the wind to pump out more water from the roots of the plants than would normally happen by transpiration alone.

List of plant responses to ethylene
 Seedling triple response, thickening and shortening of hypocotyl with pronounced apical hook.
 In pollination, when the pollen reaches the stigma, the precursor of the ethylene, ACC, is secreted to the petal, the ACC releases ethylene with ACC oxidase.
 Stimulates leaf and flower senescence
 Stimulates senescence of mature xylem cells in preparation for plant use
 Induces leaf abscission
 Induces seed germination
 Induces root hair growth — increasing the efficiency of water and mineral absorption
 Induces the growth of adventitious roots during flooding
 Stimulates epinasty — leaf petiole grows out, leaf hangs down and curls into itself
 Stimulates fruit ripening
 Induces a climacteric rise in respiration in some fruit which causes a release of additional ethylene.
 Affects gravitropism
 Stimulates nutational bending
 Inhibits stem growth and stimulates stem and cell broadening and lateral branch growth outside of seedling stage (see Hyponastic response)
 Interference with auxin transport (with high auxin concentrations)
 Inhibits shoot growth and stomatal closing except in some water plants or habitually flooded ones such as some rice varieties, where the opposite occurs (conserving CO2 and O2)
 Induces flowering in pineapples
 Inhibits short day induced flower initiation in Pharbitus nil[27] and Chrysanthemum morifolium[28

Ethylene action slows at lower temperatures.
At their minimum temperature levels, fruit is basically inactive and does not respond well to externally supplied ethylene.

Ethylene will penetrate most substances.
In fact, it will permeate through produce cardboard shipping boxes, wood and even concrete walls.

Appendix III Nov 2008
Hibernation and Cryogenics
Andre Willers
19 Nov 2008

Discussion :
Jessica Palmer pointed out on the 16th Nov 2008 that the primary problem with cryogenics seems to be in the re-establishment of metabolic processes after un-freezing .

But we have an already existing template for doing exactly that .

Hibernation .

See Appendix A

The evolutionary explanation is that during the transition-phase from methane/sulfur to oxygen atmosphere (circa 1.5 bn years ago) , there was a major advantage in suspending oxygen-driven systems if the organism found itself in a non-oxygen environment . It went into hibernation .

At the same time , alcohol was being excreted as a poison (like oxygen) . The ancestors of mitochondria (who could use low concentrations of oxygen or alcohol ) sought refuge in cells whose cell-walls were resistant (but not impervious) to alcohol transition .

Remember , alcohol is completely soluble in water , but oxygen is not . This difference drove the process . Alcohol concentrations in water could grow large , but oxygen-concentrations could not .

Mitochondria earned their keep by mopping up alcohol first and later converting oxygen to ATP . (The glucose and ketone metabolism came after this) . The ketone metabolism has never been very popular , because of the high loss-rate in excretory products , but has been kept as a third string on the bow . (Utilization of fat and protein-muscle reserves during low-glucose periods. )

Mitochondria thus has an exclusive preference of usage : alcohol , glucose , ketones in that order .

From experimental evidence (see Appendix A) , there is a genetic switch sensitive to the concentration of H2S to bring both the host cell and the mitochondrium to a state where all programmed molecular activity is suspended . (The power is switched off) .
But , of course , random beth(0) molecular activity due to temperature does not cease . Uncontrolled and anaerobic reactions still occur .

We get rid of most anaerobic organisms first .
Lots of sulfur , VitC and alcohol (fermented berries or carbohydrates in the stomach . A low acidity is required in the run-up to hibernation)
Then freeze .

Starting the contraption up again is a bit of a problem .

1. The power-plant :
The mitochondria needs to be primed with their preferred fuel (alcohol)
Oxygen needs to be infused .(Hyperbaric chamber)

2. Garbage disposal
The cellular garbage-disposal systems need to be activated . ATP from the powerplant needs to be allocated to breakdown-product disposal before the ATP is allocated to DNA/RNA production processes .

The garbage-disposal uses mechanisms that use sulfur to create the various vacuoles and ropes (cf mitosis) . Enough sulfur is vital .

Once again , oxygen and alcohol is used . Both are recognized by all systems as poisons to be removed as a first priority . They activate a quite sophisticated garbage-disposal system as H2S concentrations decrease .

3 . Flushing
All that garbage has to flushed away , preferably not through the kidneys or liver .
Use machines .
As H2S concentrations decrease , damage might occur due to PH fluctuations . Acidity (H2SO4 , etc) Buffering would be advisable .

4. Temperature:
Lots of water at 105 to 107 Fahrenheit for mammals , pulsing at pulserate(about 90 cycles per minute .)
This is to activate the chaperone systems and discourage opportunistic viruses .

5. Music
See “Music”
Play harmonious music so the vibrations can be felt throughout organism being thawed . This enhances timing-procedures by orders of magnitudes . Emergent order .
(A Beth(0.x) effect . )

The de-hibernization process must have an exact program at molecular level to reboot the cellular metabolism . Precisely what you need after a cryogenic procedure .
But its efficiency (ie your chance of survival) can be boosted by orders of magnitude by using the steps above .

Interesting notes:
1. Do hibernating animals like bears use alcohol-producing cells in their bloodstream to time hibernation? This can be tested .
2. Are there cold-chaperone molecules ? There should be .
3. Hibernation is easy . Nature has done all the hard work . Keeping the mechanism ticking over at a very slow rate enables cellular-garbage clearing for a relatively short period (6-8 months)
4. De-cryogenics is a bit harder , Beth(1) intervention is needed .
5. Alcohol-concentrations : we are talking about 1% to 2% imbibing . About 0.06% inside the cell . Ie , the cell-wall protects by a factor of about 30
6. Pulse-Cryogenics : alternate freezing and hibernation to get a better survival factor . For those who are too stupid to design a zero-entropy system .
Try : Life=negative entropy . Non-life = positive entropy . Design it so the sum is zero .



Appendix A
From “ Birdflu Update-4” dated 29 Oct 2005
Suspended Animation (the real thing!)
In 2005, Mark Roth and other scientists from the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle demonstrated that mice can be put into a state of suspended animation by applying a low dosage of hydrogen sulfide (80 ppm H2S) in the air. The breathing rate of the animals sank from 120 to 10 breaths per minute and their temperature fell from 37 °C to 2 °C above ambient temperature (in effect, they had become cold-blooded). The mice survived this procedure for 6 hours and afterwards showed no negative health consequences.
Such a hibernation occurs naturally in many mammals and also in toads, but not in mice. (Mice can fall into a state called clinical torpor when food shortage occurs). If the H2S-induced hibernation can be made to work in humans, it could be useful in the emergency management of severely injured patients, and in the conservation of donated organs.
As mentioned above, hydrogen sulfide binds to cytochrome oxidase and thereby prevents oxygen from binding, which apparently leads to the dramatic slowdown of metabolism. Animals and humans naturally produce some hydrogen sulfide in their body; researchers have proposed that the gas is used to regulate metabolic activity and body temperature, which would explain the above findings
Dosages of H2S:
Treatment involves immediate inhalation of amyl nitrite, injections of sodium nitrite, inhalation of pure oxygen, administration of bronchodilators to overcome eventual bronchospasm, and in some cases hyperbaric oxygen therapy.
Exposure to lower concentrations can result in eye irritation (because of the high alkality of the SH- anion), a sore throat and cough, shortness of breath, and fluid in the lungs. These symptoms usually go away in a few weeks. Long-term, low-level exposure may result in fatigue, loss of appetite, headaches, irritability, poor memory, and dizziness. Higher concentrations of 700-800 ppm tend to be fatal.
• 0.0047 ppm is the recognition threshold, the concentration at which 50% of humans can detect the characteristic rotten egg odor of hydrogen sulfide [2]
• 10-20 ppm is the borderline concentration for eye irritation.
• 50-100 ppm leads to eye damage.
• At 150-250 ppm the olfactory nerve is paralyzed after a few inhalations, and the sense of smell disappears, often together with awareness of danger,
• 320-530 ppm leads to pulmonary edema with the possibility of death.
• 530-1000 ppm causes strong stimulation of the central nervous system and rapid breathing, leading to loss of breathing;
o 800 ppm is the lethal concentration for 50% of humans for 5 minutes exposition (LC50).
Concentrations over 1000 ppm cause immediate collapse with loss of breathing, even after inhalation of a single breath.


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