Monday, March 25, 2013

Optimal Anti Oxidants

Optimal AntiOxidants

Andre Willers
25 mar 2013

Synopsis :
Recent research indicates that too much anti-oxidants is counter productive . 33% of Recommended Daily Allowance is better in normal cases .
Discussion :

0.This is not medical advice . See your doctor .

1.Too Much anti-oxidants .
See  . Also ScientificAmerican Feb 2013
Too much anti-oxidants decreases lifespan .
A certain concentration of oxidants are needed to trigger the various chaperones .
But how much ?

2.For a animal not subject to an acute attack (infection , major deficiency disease, etc) we can use the normal Reserve Argument .
See :
The necessary reserve is 1/3 . This is the minimum necessary sufficient amount .
(Taking 3/3 is like lying on a couch all day and expecting to grow muscles)

4.Why ?
The cells need some stress to trigger the chaperones , TOR systems and stem-cell production .
This is from evolutionary reasons . The body does not defend until it is attacked . But by then it might be too late .
But even a full-scale response to an outside attacker might be inhibited by too-enthusiastic ingestion of anti-oxidants .
The crash-manufacture of various antibodies will necessitate some shortcuts involving oxidants . Zapping them is a bit of a no-no .
See Appendix A

5. Adding oxidant stress .
Smoking and drinking alcohol . Both stimulate mTorc1 , as expected . It stimulates anti-aging and stem-cell production .
The worst thing you can do is take massive anti-oxidants after the night before  . Just keep on with the normal 1/3 RDA and drink a lot of water .
6.Acute infections .
Why Linus Pauling and Vit C failed :
VitC  in 7 gm per dose killed off intestinal fauna , freeing the immune cells clustered around the gastro-intestinal tract .
That worked .
 But the megadose of VitC also inhibited chaperone and TOR responses .
Alcohol and nicotine will work better .
A large concentration of alcohol to kill intestinal fauna , a nicotine patch to stimulate mTORc1 production .
Then probiotics and chewing gum to restore  intestinal fortitude .

7.Personal Stress Trainers .
Well , the rich already have them . Personal exercise trainers .
But an App can easily be written to do all this .

8.What if there is no RDA ?
Like Resveratrol and numerous other anti-oxidants . Well , the manufacturers have no idea either , otherwise they would have stated it . They just a thumbsuck amount for maximum sales , never mind your health . Unless you are under acute attack , they can be left out . Take their RDA = 0
9.Exercise :
Exercise is a fundamental stressor .
On a scale of 1-10  ,   1-7  (2/3) is good  . More is bad .
A delicious conclusion : very fit people will have to add some stressors to stay healthy .
This is usually described by a pulse system  : In Form , or Out of Form .
There was none of this nonsense with our ancestors . You had to be fit all the time . So they deliberately added some stressors .
Rotten meat , alcohol , mushrooms , love affairs , religion , war and peace ,mathematics , novels , poetry ,games , etc
A brisk walk on should do wonders for the constitution .
“My horse was out of form “  Ghenghis Khan on losing a battle .

Appendix A
Andre Willers
4 Feb 2012

Synopsis :
A phene-level metacontrol of cellular maturity definition .

Discussion :
TOR : Target Of Rapamycin
Rapamycin : a chemical isolated from the soil of Easter Island (Rapa Nui) in 1972 as a growth inhibitor for fungi and mammals .
Genes : TOR1 , TOR2 , etc . Genes that encode for TOR in the form of
TORC1 , TORC2 , etc , which are complexes of molecules .

These have meta-control functions :
TORC1 , for instance , monitors nutrient availability and regulates insulin , growth factors , autophagy . Neat work for a protein .
See Scientific American , Jan 2012 p22 or online .

Too neat . The decision trees are too large for a single protein .
It is much more likely that some sort of quorum mechanism is at work , defining the maturity point .
Located on the cell-walls : see Phene Systems in Appendix I repeated below for your convenience .

The argument is that a very old mechanism (pre-yeast) can and does regulate DNA and mitochondria mechanisms (autophagy) . But the critical point is the definition at biochemical level of maturity.
And it is not a point , but a fuzzy locus , that can be extended in any direction .

But maturity points would be a fairly recent invention , in evolutionary terms .
We can see it's effects in early sexual maturity and dwarfism .
See “Chitter Goo” Feb 2012

What does this mean to you and me ?
1.Eat mature mushrooms with garlic butter .
Cooking temperature not to exceed 30C .
This will elongate fuzzy maturity locus towards the old age direction .(Activates mTORC1)
2.Take MSM and various micro-nutrients to prevent bottlenecks .
3.Smoke , drink . (Deactivates mTORC1) .
Use APS and activate other amygdala's (chakras) .
See “Why radiation nauseates” Feb 2012

For the Conspiracy Theorists :
Why was Rapamycin found on Easter Island ?
Because it was the furthest remove from human quorum effects .
Their population explosion due to longevity was due to their remoteness .
Will the same be true of space colonies ?

The top-knots of the Easter Island statues were originally anti-agathic suppositories , revamped by a committee of politicians .

Andre .

Appendix I
Phene Systems II
Andre Willers
4 Feb 2011

Synopsis :
Cellular meta-control mechanisms (Phenes) situated on the cell- and nucleus wall are expanded on in more depth .

Discussion :

The article "The Inner life of the Genome" by Tom Miseli in the Feb 2011 Scientific American (p46) pulled together a number threads previously discussed in this blog .

Briefly , he found that DNA is organized in the following physical arrangements in a working cell-nucleus :
DNA -> Wound around Histone Spools -> Histone Spools fold to form Chromatin strings -> Heterochromatin strings (a very tightly folded Chromatin strings) (see para 6 below)

Heterochromatin is so tightly wound that the DNA is inaccessible to transcription factors (ie inert , switched off) . They are found mostly near the nucleus wall . The Chromatin strings form delineated tangles , with preferred positions in the nucleus space .

Near the center are volumes called Transcription factories .
This is where the rubber hits the tar .
Volumes rich in aggregations of cellular components , polymerase enzymes and transcription factors . How did they get there ? See point 4 below about Chaperones and Self-organization .

Genes on the outer Heterochromatin string , on activation from the Phene system , unwinds to make the DNA accessible . The chromatin string simultaneously also migrates inward to a transcription factory (presumably triggered by the phene signal) and gets expressed .
This has been described as the Histone Code forming the epigenetic system

From evolutionary considerations , meta-control systems on cell-level and nucleus level are taken to be related .
Not only are they descended from the same ur-mechanisms , but if they were not related , that would add another expensive translation layer between cell-wall and nucleus-wall , with concomitant chances of error .
Evolutionary pressures would have elided any such mutation .

(Sounds logical , but is it true ? I suspect it is usually true , but exceptions will be found .
The perversity of animate matter exceeds that of inanimate matter by orders of magnitude)

The Histone System can then be seen as an important subset of the Epigenetic System
But the epigenetic system can have signals that are not relevant to cells .
See "Tunneling nanotubes"

See the following main threads : "Rife and the Histone Code" Jan 2011 "Phene System" Nov 2009 (reproduced in Appendix A below for convenience .) "ATP as a neurotransmitter" Jan 2010 "Tunneling nanotubes" Nov 2010 "Coffee foam" Aug 2009 "Intralipid II" Feb 2011 "Chaperones , Unpacking and Asthma" Aug 2008

Points to note :
1; "Distributed viruses" as theorized in "ATP as a Neurotransmitter" can be better described as pleomorphic organisms as set out in "Rife and the Histone code"

2;Intralipid is important because of its ability to hide epigenetic triggers . Notice the importance of phosphatydilserine (see "Phene Systems") . What would be the effect of  phosphatydilserine with Intralipid-type mechanisms ?

3; Switching off genes near the cell-wall is a typical evolutionary fail-safe control .
(A process is inhibited , unless that inhibition is inhibited in turn)

4; When a gene in the outer-tangle of Heterochromatin strings is activated , the loop it is in drops in nearer to a Transcription factory .
How does it know where to go ?
One theorizes that initially it is self-organizing (ie a hit-or-miss affair) . But various Beth levels will force an evolution of chaperones (see "Chaperones , Unpacking and Asthma" Aug 2008 )
So , one envisages a mixture of chaperones(2/3) and self-organization (1/3) ( "NewTools reserves" Nov 2008 . Error arguments.)

5; Chromosome abnormalities (like cancer) . Without a chaperone the dangling loop is vulnerable to breaking and then joining up with an unsuitable partner . Like in any bad marriage , the children suffer .

6.Stem Cells :
The above description is for a mature , functioning differentiated cell .
Things are different just before and after divisions .
In Embryonic stem-cells , there are no Heterochromatin strings .
All the genes are active , but the shebang is not very robust .

On receiving a phene-signal to differentiate the cell , lamin proteins are formed and fold Chromatin strings -> Heterochromatin strings and also tether them to the nucleus wall . The nucleus becomes much more robust .
Lamin proteins can then be classified as chaperones .
But notice how easily nearly any cell can be turned back into a pluripotent cell .
The body does this all the time (lately , stem cells have been created out of cells found in  urine .This is very unlikely for a storage mechanism .)

From Wikipedia :
"The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. Thelamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression."

The lamins are thriftily reprocessed during mitosis . This means there is an programmed biological pathway to reverse differentiation (ie create stem cells) . Which why stem cells are so easily created .

The only problem now is why the body does not do it more frequently (ie why grow old?) It seems that the phene system has a memory , and the new cells after mitosis are reprogrammed .

Any helpful suggestions are welcome .
(Old age sucks.)

7; Heat pulses and Timing .
From para 4 above (Self-organization) , random movement due to heat promotes self-organization .
The molecules creating timing mechanisms are evolutionary very old (recent findings) . Heat pulses at harmonics of the diurnal rhythm should entrain the self-organizing process and reduce copying errors quite drastically .
(Remember , a modest 10 degree Celsius rise in temperature doubles chemical activity on a molecular level)

The Tea Ceremony .
An existing and proven technology .

The number of seconds in a day = 3^3 * 2^7 * 5^2 = 86 400
Sipping a very hot liquid every x seconds will pulse with resonances at
X= 2,3,4,5,6, 8,9,10,12.15,16,18,20,24, 25,27,30,… seconds
About 2-3 seconds per sip seems doable . The liquid must be kept hot and the sip rate maintained . This is ok for stomach systems .

We know long-term nerve potentiating is about 10 minutes , so if nervous system is targeted , sip slower (but not longer than 6 seconds between sips) and the tea must be kept at the same temperature . Eg for 6 seconds between 2.5 ml sip , you will drink 10*60/6*2.5 = 250 ml (about one cup .) 

Will a Tea Ceremony with iced tea have the same effect ?
If the nervous system is targeted , yes . Entrainment is the goal . So the bigger the temperature difference , more the body will notice . Remember the caffeine .

The maximum effect if you want to target the nervous system (relax, etc) would be then to do the Tea Ceremony and make each alternate sip iced tea and very hot tea as described above . Each in a demi-tasse .

I'm afraid Tea Ceremony purists in Japan and China will not welcome this conclusion

In other cases , you can experiment , but I estimate that hot alone will work .

Bar flies , hot chocolate and hot/iced coffee I leave for enthusiastic students .

Or else you can pulse infrared at these rates and frequencies derived from Rife's work

Or else sit in the sun with a shade that fluctuates (old style Eastern potentate , or rotating sun-umbrella with variable panels)

Or else watch TV . Heat radiation on old cathode-ray TV's will resonate at 25 , 27 ,30 times per second .
Children sitting close will be more susceptible .
Watching TV on CRT's makes them healthier ?  Some independent verification is required here .
Computer screens and games ditto .

That was fun !



Appendix A
Phene Systems.
Andre Willers
5 Nov 2009

Synopsis :
Cellular-wall control systems(phenes) of epigenetic and virus systems are becoming known and described .

Discussion :
See NewScientist 8 Aug 2009 p 41 "Kills all known germs" by B Holmes .
Relevant research by Philip Thorpe at University of Texas Southwestern Medical Center in Dallas .

See also "Coffee Foam" 2 Aug 2009 and later .

The argument is simple : self-replicating structures started on the walls of bubbles (probably clay : Gecko life) . These developed into the present day epigenetic control structures of processes inside the bubbles (ie cells) .
Viruses are messengers/controls both for intra-cellular and extra-cellular use .
Which is why they are usually wrapped in variants of the cell-wall .

Phosphatidylserine :
From the NewScientist article , this is a molecule mostly found sticking out of the inner lining of the cell-wall . Virus budding entails that this molecule is then found in particular patterns sticking out of the outside the outer cell-wall .

We expect such a mechanism if the cell-wall harbours the meta-controls (ie epigenetics) of the cell and some multicellular activity (ie virus messenger generation).

Humans have created antibodies that inactivate or target-for-destruction the bits of the Phosphatidylserine molecule sticking out of the cell-wall .

This will break the feedback-cycle of a large range of harmful viruses (apparently including HIV , Flu's , some cancers) .
Bavituximab ( a name only a Pharma could love) does exactly this . Expect to see a lot of it .

The question is :
Why are these antibodies not part of the body's normal immune system ?
The virus system is also used for information carrying .

Suppressing the virus system completely will destroy a multicellular organism , and make it revert to a collection of individual cells , even down to elemental chemicals if done properly . (Cf Ebola , SuperEbola ,  etc)

This can be bypassed by shining intense , quantum-entangled infra-red light through the mess (see previous posts) .

The normal system has to play a delicate balancing act between destruction from bad viruses and good,communication viruses .

If the baddies get too big an influence , intervention might be required . This is the duty of the epigenetic system . Why is it falling down on the job ?

The Dendritic Immune sytem
This is the connection between the synapse-type learning systems and the phene-system in the cell walls .

The dendritic immune  system's effectiveness is magnified by at least 3 orders of magnitude by a continuous sharp pressure-differential . The search space is drastically reduced by stochastic resonance . (The proof is either immediately obvious or very long).

Hence modern music and it's prevalence .

Your chances of survival is about 10^3 better if you listen to some semi-random rock.
Hence iPod and others . This is a real effect .

But we can do better than that by internal Click programming .
You know : Clicking the tongue , beak , teeth , exoskelet .

There is no animal with synapses or an immune system that makes no clicks at some stage .
This is actually quite amazing .

We would then expect plants to be noisy . And they are , on very low frequencies . This is how desert elephants survive : they hear the bulbous plants growing by the low-frequency pulses sensed through their feet . A patch of bulbs would have a signature low-frequency pulse observable from a long way off . (The bulbs would evolve-learn to spurt growth at the same time . This would lessen the chance of detection and eating by close-by herbivores not as smart as elephants)

Click-talking plants .
Better than just talking to them . But try some castanets . Tap-dancing will work too , but the neighbours will think you're really crazy tap-dancing to the plants . Tojours .

Grinding your teeth .
A common complaint , usually explained away as stress . Actually , your teeth are trying to click together . A part of the body's housekeeping routine . Programming the gums and intestinal tract .

Just for the hell of it , click your teeth together 5 times together with 5 double-tongue clicks interspersed as you feel . Count them . You will feel an immediate stress-relief feeling . Blood pressure will drop . Be careful if medication to lower blood pressure is taken .

I just thought of the above , and tried it .
The teeth (molars mostly) must click against each other . You will notice there is a damage-control protocol hardwired in . The teeth will click , but not hard enough to cause damage . This already tells us that this is an old system .

The natural tendency will be for a double-teeth click , followed by a double tongue-click with the mouth open . The process then repeats , varying the teeth , tongue and mouth open/closed .

Be careful of hypotension of the cardiovascular system . The stress relief is very pronounced . Especially around the neck and upper shoulder muscles .

Teeth-grinding should cease .

But why ?
I did not expect this . But the effect is so pronounced that I cannot ignore it .
The neck and shoulder muscles do not relax through  an effort of will or exercise . They just relax . (Sort of melt) .

Maybe a double bite-bite on empty air signals the end of an aggressive episode , and for expensive fight-or-flight mechanisms to stand down .

This would make this fairly deep-wired , certainly deeper than psychological stress .

Phene effects .
The stand-down is an immediate stand-down , regardless of the number previous stress-generating events . This must be true , since this is the epigenetic programming system . There is no other memory system .

Phene programming of immune-systems , bone-growth , digestion , neural growth etc ,are immediately affected . Genes are switched from crisis to maintenance . Using the carbohydrate-energy mechanism is a short-term crisis mechanism .

Standing down the mechanism should ameliorate conditions like Diabetes II .

Or getting fat .

Want to get thin ?
The algorithm :
Double-teeth click , followed by a double tongue-click with the mouth open . The process then repeats , varying the teeth , tongue and mouth open/closed .
Repeat  at least ten times a month .
That’s it .

Can it be this simple?
Yes .

Why has nobody thought of it before ?
As far as I am aware , nobody in our recorded history has thought that the click of teeth together can have physiological effects . Prehistoric societies were probably aware of the effect .

Yet it does , as you can find out for yourself .
The same for the simplicity . Simple causes has wide effects , because they are so basic . You must look at the whole argument .

In any case , there is hardly any risk .
I am doing it . Tojours!

Hasta la vista !
Coming or going .

Andre .

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