RLS and Parkinson’s genes
Andre Willers
28 Mar 2013
Synopsis :
Restless Legs Syndrome(RLS) and Parkinson’s Disease are
connected by genetic problems on Chromosomes 12 , 14 and 9 . The trigger for
Parkinson’s is self-poisoning through 6-Hydroxydopamine(6-OHDA)
in urine .
Discussion :
1.See Appendix I to Appendix VI for how we trace the effect
.
2.Appendix VII and VIII reveals the mechanism and a possible
counteraction .
3. 6-OHDA in urine kills the dopamine-generating cells . See
appendix VIII .
“The motor symptoms of Parkinson's disease result
from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain.”
The 6-ODHA is normally kept in check by the strong terminal
anti-oxidant effects of Melatonin during sleep .
But age and life-style decreases melatonin . Urine retention
exacerbates feedback of 6-OHDA into the
bloodstream . A genetic weakness progresses from Restless Legs to Parkinson’s .
Literally , auto-poisoning .
4.What to do :
This is not medical advice . Consult your doctor .
4.1 Take a melatonin supplement at night .
4.2 Take a dopamine precursor (like L-Tyrosine ) in the
morning .
4.3 Stimulate dopamine production after about 30 minutes
with a very bright light .
An easy and cheap way to do it is with an electronic camera’s
flash (with eyes closed) .
It is the intensity of the light that matters , not the
duration . Repeat as needed .
4.4 Make sure that the uro-genital tract is free of
infection or lesions .
4.5 Take about 1 teaspoon of bicarbonate of soda twice a day
an hour before meals (for kidney repair)
4.6 Drink sufficient
liquids , but do not try to hold your water .
4.7 Change underwear at night and at morning . This reduces
6-ODHA concentrations on clothes .
4.8 Use chewing gum . The eating-process programs the whole
system in a very deep way .
4.9 Babies and nappies : can Parkinson’s Disease be
programmed in at baby stage by wet nappies ?
An interesting aside :
Is the incidence of Parkinson’s in snipers or long-distance
runners significantly higher than average ?
All of them pee in their pants .
Here’s to the chamber pot .
Regards
Andre
xxxxxxxxxxxxxx
Appendix I
Chromosomes 12q , 14q , 9p are implicated in nerve damage .
xxxxxxxxxxxxxxx
Appendix II
Note Parkinson’s and Alzheimer’s
Xxxxxxxxxxxxxx
Appendix III
Note Alzheimer’s
GCH1 gene .
A sort of inverse Restless Leg Syndrome .
·
diurnal affect of
condition: morning(fresh/energetic), lunch(stiff limbs), afternoon(very stiff
limbs), evening(limbs worsening), bedtime(limbs near frozen).
·
muscle tension in
thighs/arms: morning(normal), lunch(abnormal), afternoon(very abnormal),
evening(bad), bedtime(frozen solid).
Xxxxxxxxxxxxxxxxxx
Appendix IV
Symptoms of mild disorders that grow worse :
Neuropathy and bad back .
Terminal Parkinson’s in the womb .
xxxxxxxxxxxxxxxxxx
Appendix V
Drooling . Motor control of the mouth and swallowing .
Try chewing gum .
Xxxxxxxxxxxx
Appendix VI
Pre-synaptic model of diurnal dopamine fluctuation
Xxxxxxxxxxxxxxxxxxxx
Appendix VII
Melatonin as protection against Parkinson’s
Neuroprotection of the
nigrostriatal dopaminergic neurons by melatonin in hemiparkinsonium rat.
Source
Department of Physiology, Maulana Azad Medical College, New Delhi,
India.
Abstract
BACKGROUND
& OBJECTIVES:
Several lines of
evidence point to a significant role of antioxidants in Parkinson's disease
(PD). Few studies report that melatonin, a neurohormone, is one of the best
physiological antioxidants. Review of literature indicates that none of the
drugs so far studied for preventing the PD was found to be promising for use.
Therefore in the present study the effect of neuroprotectory melatonin was tested
against 6-hydroxydopamine (6-OHDA) neurotoxicity for striatal dopaminergic
neurons in the rat.
METHODS:
Thirty animals were
randomly divided into two groups. Animals of group 1 received saline (melatonin
vehicle) daily 1 ml ip for seven days. Melatonin (500 mug/kg body weight
dissolved in 1 ml saline ip) was administered in rats of group 2 for seven
days. Then all animals of groups 1 and 2 were lesioned unilaterally with 8 mug
6-OHDA into the lateral striatum on 8(th) day. Various behaviour and histological
tests were used to evaluate the neuroprotective effect of melatonin.
RESULTS:
Statistically
significant difference in various behaviour tests was found between post lesion
values of group 1 and group 2 (P<0 .001="" and="" apomorphine-induced="" balance="" behaviour="" disengage="" in="" initiation="" o:p="" p="" postural="" rate="" rotational="" staircase="" stepping="" success="" test="" time="">0>
INTERPRETATION
& CONCLUSION:
Our results demonstrated
that melatonin acted as an effective neuroprotective agent for striatal
dopaminergic neurons in 6-OHDA lesioned rat model of Parkinson's disease.
(6-OHDA causes Parkinson’s : see http://www.sciencedirect.com/science/article/pii/S0014488605000154
or
xxxxxxxxxxxxxxxxxxxxxxxx
Appendix VIII
“6-Hydroxydopamine(6-OHDA) is a naturally occurring amine in human urine. “
Poisonous piss .
xxxxxxxxxxxxxxxxxx
No comments:
Post a Comment