Thursday, March 28, 2013

RLS and Parkinson's Genes

RLS and Parkinson’s genes

Andre Willers
28 Mar 2013
Synopsis :
Restless Legs Syndrome(RLS) and Parkinson’s Disease are connected by genetic problems on Chromosomes 12 , 14 and 9 . The trigger for Parkinson’s is self-poisoning through  6-Hydroxydopamine(6-OHDA)  in urine .
Discussion :
1.See Appendix I to Appendix VI for how we trace the effect .
2.Appendix VII and VIII reveals the mechanism and a possible counteraction .
3. 6-OHDA in urine kills the dopamine-generating cells . See appendix VIII .
“The motor symptoms of Parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain.”
The 6-ODHA is normally kept in check by the strong terminal anti-oxidant effects of Melatonin during sleep .
But age and life-style decreases melatonin . Urine retention exacerbates  feedback of 6-OHDA into the bloodstream . A genetic weakness progresses from Restless Legs to Parkinson’s .
Literally , auto-poisoning .
4.What to do :
This is not medical advice . Consult your doctor .
4.1 Take a melatonin supplement at night .
4.2 Take a dopamine precursor (like L-Tyrosine ) in the morning .
4.3 Stimulate dopamine production after about 30 minutes with a very bright light .
An easy and cheap way to do it is with an electronic camera’s flash (with eyes closed) .
It is the intensity of the light that matters , not the duration . Repeat as needed .

4.4 Make sure that the uro-genital tract is free of infection or lesions .
4.5 Take about 1 teaspoon of bicarbonate of soda twice a day an hour before meals (for kidney repair)
4.6  Drink sufficient liquids , but do not try to hold your water .
4.7 Change underwear at night and at morning . This reduces 6-ODHA concentrations on clothes .
4.8 Use chewing gum . The eating-process programs the whole system in a very deep way .

4.9 Babies and nappies : can Parkinson’s Disease be programmed in at baby stage by wet nappies ?
An interesting aside :
Is the incidence of Parkinson’s in snipers or long-distance runners significantly higher than average ?
All of them pee in their pants .
Here’s to the chamber pot .
Appendix I
Chromosomes 12q , 14q , 9p are implicated  in nerve damage .
Appendix II
Note Parkinson’s and Alzheimer’s
Appendix III
Note  Alzheimer’s

GCH1 gene .
A sort of inverse Restless Leg Syndrome .
·         diurnal affect of condition: morning(fresh/energetic), lunch(stiff limbs), afternoon(very stiff limbs), evening(limbs worsening), bedtime(limbs near frozen).
·         muscle tension in thighs/arms: morning(normal), lunch(abnormal), afternoon(very abnormal), evening(bad), bedtime(frozen solid).

Appendix IV
Symptoms of mild disorders that grow worse :
Neuropathy and bad back .
Terminal Parkinson’s in the womb .
Appendix V
Drooling . Motor control of the mouth and swallowing .
Try chewing gum .

Appendix VI
Pre-synaptic model of diurnal dopamine fluctuation
Appendix VII
Melatonin as protection against Parkinson’s
Neuroprotection of the nigrostriatal dopaminergic neurons by melatonin in hemiparkinsonium rat.
Department of Physiology, Maulana Azad Medical College, New Delhi, India.
Several lines of evidence point to a significant role of antioxidants in Parkinson's disease (PD). Few studies report that melatonin, a neurohormone, is one of the best physiological antioxidants. Review of literature indicates that none of the drugs so far studied for preventing the PD was found to be promising for use. Therefore in the present study the effect of neuroprotectory melatonin was tested against 6-hydroxydopamine (6-OHDA) neurotoxicity for striatal dopaminergic neurons in the rat.
Thirty animals were randomly divided into two groups. Animals of group 1 received saline (melatonin vehicle) daily 1 ml ip for seven days. Melatonin (500 mug/kg body weight dissolved in 1 ml saline ip) was administered in rats of group 2 for seven days. Then all animals of groups 1 and 2 were lesioned unilaterally with 8 mug 6-OHDA into the lateral striatum on 8(th) day. Various behaviour and histological tests were used to evaluate the neuroprotective effect of melatonin.
Statistically significant difference in various behaviour tests was found between post lesion values of group 1 and group 2 (P<0 .001="" and="" apomorphine-induced="" balance="" behaviour="" disengage="" in="" initiation="" o:p="" p="" postural="" rate="" rotational="" staircase="" stepping="" success="" test="" time="">
Our results demonstrated that melatonin acted as an effective neuroprotective agent for striatal dopaminergic neurons in 6-OHDA lesioned rat model of Parkinson's disease.

Appendix VIII
“6-Hydroxydopamine(6-OHDA)  is a naturally occurring amine in human urine. 
Poisonous piss .

No comments: