Saturday, May 31, 2014

Immortality Update 6 : IGF-1

Immortality Update 6  :  IGF-1


Andre Willers
31 May 2014
“Hope is always desperate.”
Synopsis :
We stimulate liver production of IGF-1 directly via random secretagogue production, bypassing the HGH mechanism . We hope that functional selectivity keeps the contraption within survivable boundaries .
 
Discussion :
1.HGH (Human Growth Hormone) regulates cellular division and apoptosis . How you live , grow and die .
 
2. The major tool is IGF-1 (Insulin Like Factor- 1) , produced in the liver .
See Appendix BB
Notice the Grandmother (age 75) and Grandfather (age 65)  effects .
    
3.HGH secretagogues are very expensive and not all that effective . Ditto actual HGH .
Because all the control factors are absent .
 
4.   So we simply shotgun it .
We use the technique (psyllium husk reaction chambers and microwaves) as set out in Appendix CC to produce a very large range of bio-reactive materials  from known liver activators .
We simply semi-randomly create a large variety of HGH related molecules and let God sort them out .
 
In this case , Milk Thistle ( appropriately named Silybum  http://en.wikipedia.org/wiki/Silybum )
An adult dosage for about male age 65 should do . ( 400 mg in powder and/or extract form .)

 
5. There must be deleterious materials in them . So ,we rely on selective receptor modulators to weed out the dangerous ones . See Appendix AA .
These also serve as innoculators .
 
6. Precise targeting :
Simply spit into the original sample . DNA and epigenetics serve as templates for amplification in reaction chambers . (The Gothic inclined can use a drop a blood )
 
7. Will PCR techniques help ?
If a DNA sample is included , it probably would .
 
8. The Kitchen Recipe :
8.1 Mix a ½ teaspoon of Psyllium husks with the 400 gm milk thistle extract with 100 ml water .
8.2 Spit in it (If you are doing DNA targeting) . Mix . Stand for 10 minutes to allow population of reaction chambers . Then PCR it . This is but a primitive sketch , suitable for a kitchen .
  
8.3 PCR Start cycle:
8.3.1 Microwave  till  95 C
8.3.2 Cool till 60 C
8.3.3 Microwave till 72 C
End cycle .
 
8.4 Number of cycles:
For this sort of purpose , 3-8 cycles should suffice .
 
8. How safe is this ?
Not very .
From Appendix BB , there seems to be a reasonable expectation of something happening .
But the odds favour that it would be bad , except for functional selectivity .
A sort of Darwin’s Daemon  , that lets only beneficial mutagens pass . Also known as the immune system .
 
Well , you certainly will stimulate your immune system out of its torpor .
 
9.You have to be desperate , or trying for the Darwin award to do this in your kitchen without proper safeguards .
 
10 . But , if you are terminal from cancer , old age , etc , you might as well go out fighting .
With  functional selectivity you stand a fair chance of dodging random bad things .
 
Who knows ?
Your immune system might learn to sing . Just like the horse .
And this a real Picasso sketch . Alien envy .


 
Have fun !

Andre
 
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Appendix AA
New findings that broaden the conventional definition of pharmacology demonstrate that ligands can concurrently behave as agonist andantagonists at the same receptor, depending on effector pathways or tissue type. Terms that describe this phenomenon are "functional selectivity", "protean agonism",[4][5] or selective receptor modulators.[6]
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Appendix BB
Notice Grandmother Effect after age 75 for females .
Notice new lease on life after age 65 for males (this was not expected) .Grandfather Effect ?
Max 5
Max IGF-1
IGF-1
Max 5
Max IGF-1
IGF-1
Age male
ng/mL
Extra
Age female
ng/mL
Extra
25
344
0
25
323
21
30
275
69
30
271
73
35
241
103
35
244
100
40
226
118
40
225
119
45
210
134
45
205
139
50
201
143
50
194
150
55
201
143
55
191
153
60
194
150
60
173
171
65
191
153
65
168
176
70
195
149
70
168
176
75
187
157
75
166
178
80
184
160
80
168
176
85
182
162
85
179
165
90
182
162
90
179
165


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Appendix CC

Friday, May 30, 2014
Water of Being .
Stability of Water .


Andre Willers
30 May 2014
Synopsis :
Water and doped water has many discontinuous metastability regions . There are many economic applications .

Discussion :
1.Concept of metastability  : http://en.wikipedia.org/wiki/Metastability
Note that metastable states then have finite boundary levels .

Lower entropy is maintained in a domain because of lack of a triggering mechanism .
Well known example : leave a cup of water in a microwave too long . If you disturb it , it boils over .
The water was in a metastable state .

2. What does this mean ?
It means that we can lock in higher energy states (like a battery) or information (like molecule shapes) by using the metastability of water .

3. There are three factors that affect the stability states : Pressure , temperature and time .

4.Shockwaves :
These manipulate all three .
A shockwave increases/decreases pressure , and temperature , more rapidly than normal .

5. During this , as the shockwave passes , many different stability states are created .

6. Repeated shockwaves at the correct frequency increases the chosen stability state .
Stability bubbles will coalesce .
(A quantum effect . Might even be resonance at a distance . FTL communication ?)

7. Doped water .
Plain H2O then has memory of a limited kind , and duration (about 256 bits per phase transition)
But if it contains matter , especially deliciously resonant organic molecules , the number of metastable states increase by at least 3^(3^3) ~ 7.625 x 10^12   times .
This is about 1.952 x 10^15 bits .
The human mind is estimated to contain about 8.796 x 10^14 bits .
Doped water in a neuronal cell then contains an order of magnitude greater computational ability than the whole organism .
Does this make sense ?
Yes .
Also called the unconscious mind .
Distributed hierarchical computing .
And you are the pinnacle of that achievement !


8. These states are discontinuous with finite boundaries . They might be close , but not continuous .

9. This means that even small discontinuous influences (the sound of a truck going by , somebody dropping a pencil , playing rock music , etc) will affect the outcome of the experiment . Just compensate for them , like sound-cancellation . Well within our tech capabilities .

10 . Applications of the humorous kind :
Barely failures :
10.1 Cold fusion :
Worked sometimes , sometimes not . Cancel outside vibrations and vroom off .

10.2 Homeopathic medicine :
So close ! But so far !
The trick is in the succussion . https://www.youtube.com/watch?v=vMK_wLYKpF0
They ignored the only active element !
And that is the single element they did not standardise .
The hidden assumption strikes again !
The baby is thrown out with the bathwater .

11.Industrial applications :
Well , the above discussion described chaotic assembly of chemical compounds , which is used in a third of chemical engineering .
The only difference is that more complex pressure differentials are used .

12. Speeding things up .
From Appendix A , you will notice that most mathematical analyses are done on 1/(r^2) basis , ie unconstrained pressure wave . But in real life that never happens .

We constrain things by putting them in reaction chambers and stirring the hell out of them .
A simple way is Psyllium Husks and Microwaves .
The constraints are random , but that just makes it more interesting .
Many new compounds will be generated . (Hopefully , none will kill you – Darwin)

If you want to go the homeopathic route , simply take a drop , add psyllium , microwave , etc .
Note that you have the same problem with water as mathematicians have with randomness .
Can you exclude meaning ?
Of course you can’t .
Meaning spontaneously assembles out of finite random choices from an infinite smorgasbord .

13. Kitchen proof :
13.1 Coffee : 1 tsp instant coffee , ½ tsp psyllium husks ,add water ,  mix well , wait 10 minutes , microwave .
It tastes like a high end coffee .
Many of the aromatics have been randomly recreated in the psyllium reaction chambers .

13.2 Second Level coffee :
Take a ½ tsp of coffee from above para 13.1 , repeat . What does it taste like ?
I tried it . It tasted like very refined coffee . The lighter aromatics .
I presume  after a few more refinings it will be fit only for angels , since only they could taste it .

14. Major applications :
14.1 Perfume . Create new perfumes . Revitalize old ones .
Brew new potent sex pheromones in your kitchen ! (Beware of roach contamination)
14.2 Tastes .New tastes . Can’t wait to try this on curry . Or any spice .
14.3 Antibiotics . Put new discoveries on fast-forward . Kill them all!

15.Interesting things should be going on in galactic water clouds near  supernova’s .
Kilonovas might be stellar engineering .
Cloud intelligences are a real possibility .

Imagine if every waterdrop falling is smarter than you . What a worldview !

Every teardrop contains your multiplicities  .
Andre


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Appendix A
References for the faint of heart . Just ignore them .



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