Friday, May 23, 2014

Zap pesky insulin resistance

Insulin resistance zap .

Andre Willers.
24 May 2014 .
Synopsis :
We create Protectin DX from omega-3 flaxseed via bioreactor Psyllium-husks . A tbsp. flaxseed oil , a ¼ psyllium husk and a 2 sec microwave nuke  gives an insulin resistance zap .
Discussion :
1.Protectin DX is derived from Omega-3 fatty acids . It is also a “cure” for diabetes type II , as it is a secretagogue for IL-6 .  See appendix AA
This simply means that it reduces the insulin resistance of muscle cells .
2. Protectin DX is not yet available outside labs , but we can make our own .
3. We use the reactive surfaces of Psyllium husks to produce meaningful amounts of Protectin DX.
See Appendix AA
4. See the surface of Psyllium husks :

Notice all the reactive surfaces and pockets .
This is a micro-chemical reactor .
Ideal for producing reactions from omega-3 fats .
Including Protectin DX .
5. What amount of Protectin DX is needed :

328.488 gm/mole
Avogrado constant number of molecules per mole = 6.022 x 10^23
Number of Muscle cells~ 20 x10^12
If we need one molecule per muscle cell , then that is
Grams of Protectin DX needed (approx.)  ~ 328 x (20 x 10^12 / (6.022 x10^23))
This is about 1.093  x10^-8 gm .
Kinda small .
As a matter of fact this is the order of magnitude expected with homoeopathic effects .
6. Let’s beef it up a little .
A tablespoon  of flaxseed  oil mixed with a ¼ tsp of psyllium husks  (let stand for 10 minutes)
Should give enough Protectin DX .
Zap it in the microwave for a second or two  .
Remember , chemical reactivity doubles with every 10 C increase .
So does all those reactions in the Psyllium reaction chambers producing Protectin DX , amongst other things .
7. A bit of overkill , but minimalism at this scale is not called for , as Psyllium reaction chambers are involved .
8. The recipe :
A tbs(15 ml) of flaxseed oil (linseed oil) or any omega-3 oil .
About 2ml (1/2tsp) psyllium husks .
Mix well and stand for 10 minutes .
Nuke in microwave for about 2 seconds (900 W) \
Stand for about 10 minutes .
The standing is for the bioreactor pockets in the psyllium husks to get active .
Then drink .
9. Bioreactor effects .
The psyllium surface pockets  are chemically equivalent to the succession (shaking) effects seen in homeopathic medicines , just more effective . Especially if you give it a kick with microwaves .
10. In other words , you can make quite effective low-molecule count medicines by shot-gunning them with microwaves in psyllium reactor chambers .
11. You can do this with any other medicine that is not very effective .
12 . Boojums :
This presumes that the derivitives are benign , or not harmful .’
However , some would be Boojums , where even a small number of molecules will make you vanish.
Good luck !

Appendix AA
Protectin DX

We previously demonstrated that low biosynthesis of ω–3 fatty acid–derived proresolution mediators, termed protectins, is associated with an impaired global resolution capacity, inflammation and insulin resistance in obese high-fat diet–fed mice1. These findings prompted a more direct study of the therapeutic potential of protectins for the treatment of metabolic disorders. Herein we show that protectin DX (PDX) exerts an unanticipated glucoregulatory activity that is distinct from its anti-inflammatory actions. We found that PDX selectively stimulated the release of the prototypic myokine interleukin-6 (IL-6) from skeletal muscle and thereby initiated a myokine-liver signaling axis, which blunted hepatic glucose production via signal transducer and activator of transcription 3 (STAT3)-mediated transcriptional suppression of the gluconeogenic program. These effects of PDX were abrogated in Il6-null mice. PDX also activated AMP-activated protein kinase (AMPK); however, it did so in an IL-6–independent manner. Notably, we demonstrated that administration of PDX to obese diabetic db/db mice raises skeletal muscle IL-6 levels and substantially improves their insulin sensitivity without any impact on adipose tissue inflammation. Our findings thus support the development of PDX-based selective muscle IL-6 secretagogues as a new class of therapy for the treatment of insulin resistance and type 2 diabetes.


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