Friday, January 09, 2015

Fast Train to Longevity for Ravioli Express .

Fast train to Longevity

Andre Willers
9 Jan 2015
Synopsis :
We use Ravioli to deliver H2S and adjuvants  indistinguishable from endogenous H2S . 3D Printers are advisable . Endurance athletes will benefit greatly .
Discussion :
1.See Slow Train to Longevity in Appendix AA or
The longevity effect is because of the hibernation effect of H2S .
It slows down metabolisms of different systems like immune system , inflammation systems , sugar , etc at different rates .

2.Endogenous and exogenous H2S .
There seems to be little difference , except concentration and whether introduction is extra-cellular(exogenous) or intra-cellular (endogenous)
3.We want to introduce 80 ppm H2S from the outside that is indistinguishable from endogenous H2S .
We make Ravioli filled with 80 ppm H2S (dissolved) and formic acid .
Cook (boil) for about 5 minutes (not too long) .
Eat with any sauce , but hold the melatonin .

4.How  H2S works .
“Hydrogen sulfide under high pressure has recently been demonstrated to undergo superconducting transition at 190K, the highest temperature superconductor known to date. 
Only   -83 Celsius . Liquid nitrogen freezes at 63 K (−210 °C) .
The lowest natural temperature ever directly recorded at ground level on Earth is −89.2 °C (−128.6 °F; 184.0 K), which was at the Soviet Vostok Station in Antarctica, on July 21, 1983. Thus , H2S can be superconductive (but at high pressure) on the Earth’s surface .
Wow ! That is weird for such a simple molecule . I have no idea whether it is relevant .

“Hydrogen sulfide is slightly soluble in water and acts as a weak acid, giving the hydrosulfide ion HS (pKa = 6.9 in 0.01-0.1 mol/litre solutions at 18 °C). A solution of hydrogen sulfide in water, known as sulfhydric acid or hydrosulfuric acid, is initially clear but over time turns cloudy. This is due to the slow reaction of hydrogen sulfide with the oxygen dissolved in water, yielding elemental sulfur, which precipitates out.”
It has limited shelf life .

5 How .Formic Acid works .
This is to penetrate the cell walls and make the H2S like endogenous H2S . The concentration will have to be determined , but about the same as a nettle .

6. Inflammation example
“Conclusions and implications:
Whereas exogenous H2S delivered to the knee joint can produce a significant anti-inflammatory and anti-nociceptive effect, locally produced H2S exerts little immunomodulatory effect. These data further support the development and use of H2S donors as potential alternatives (or complementary therapies) to the available anti-inflammatory compounds used for treatment of joint inflammation or relief of its symptoms.”
Bon Appetit for life

Appendix AA
Slow train to longevity
Andre willers
28 Dec 2014

Endogenous H2S increases lifespan .

Discussion :
1.H2S is back !

H2S and the molecular mechanics of freezing metabolisms .

See Appendix A below for latest findings . Endogenous H2S creation increases lifespan . A sort of fast hibernation .

2.Why endogenous H2S?
Safety switch . Organisms without it simply goes into hibernation at the first volcanic eruption , and gets eaten by those with the safety switch .

3. How it works . 
(1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S. We also show that physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and facilitate the induction of hippocampal long-term potentiation. These observations suggest that endogenous H2S functions as a neuromodulator in the brain.

4.Also the general metabolism .

This gives all the foods to avoid . 
CBS activator, S-adenosyl-L-methionine, enhances H2S production

5.Fasting every third day will then work . But stop MSM addititives during fasting.

6. Intermittent fasting 

Eat your heart out .


Molecular mechanism behind health benefits of dietary restriction identified

Increasing endogenous hydrogen sulfide production during dietary restriction plays a major role in delivering the benefits of longevity and stress resistance.
Credit: Image courtesy of Harvard School of Public Health
A new study led by Harvard School of Public Health (HSPH) researchers identifies a key molecular mechanism behind the health benefits of dietary restriction, or reduced food intake without malnutrition. Also known as calorie restriction, dietary restriction is best known for its ability to slow aging in laboratory animals. The findings here show that restricting two amino acids, methionine and cysteine, results in increased hydrogen sulfide (H2S) production and protection against ischemia reperfusion injury, damage to tissue that occurs following the interruption of blood flow as during organ transplantation and stroke. Increased H2S production upon dietary restriction was also associated with lifespan extension in worms, flies, and yeast.
Although H2S gas is extremely toxic in high amounts, low levels present in naturally occurring sulfur springs have long been associated with health benefits. Mammalian cells also produce low levels of H2S, but this is the first time that this molecule has been linked directly to the health benefits of dietary restriction.
"This finding suggests that H2S is one of the key molecules responsible for the benefits of dietary restriction in mammals and lower organisms as well," said senior author James Mitchell, associate professor of genetics and complex diseases. "While more experiments are required to understand how H2S exerts its beneficial effects, it does give us a new perspective on which molecular players to target therapeutically in our efforts to combat human disease and aging."
The study appears online December 23, 2014 in Cell.
Dietary restriction is a type of intervention that can include reduced overall food intake, decreased consumption of particular macronutrients such as protein, or intermittent bouts of fasting. It is known to have beneficial health effects, including protection from tissue injury and improved metabolism. It has also been shown to extend the lifespan of multiple model organisms, ranging from yeast to primates. The molecular explanations for these effects are not completely understood, but were thought to require protective antioxidant responses activated by the mild oxidative stress caused by dietary restriction itself.
First author Christopher Hine, research fellow in the Department of Genetics and Complex Diseases, and colleagues demonstrated that one week of dietary restriction increased antioxidant responses and protected mice from liver ischemia reperfusion injury, but surprisingly, this protective effect was intact even in animals that could not mount such an antioxidant response. Instead, the researchers found that the protection required increased production of H2S, which occurred upon reduction of dietary intake of the two sulfur-containing amino acids, methionine and cysteine. When the diet was supplemented with these two amino acids, increased H2S production and dietary restriction benefits were both lost.
The investigators also found that genes involved in H2S production were also required for longevity benefits of dietary restriction in other organisms, including yeast, worms, and flies.
"These findings give us a better understanding of how dietary interventions extend lifespan and protect against injury. More immediately, they could have important implications for what to eat and not to eat before a planned acute stress like surgery, when the risk of ischemic injury can be relatively high," said Hine.

Journal Reference:
1.                   Christopher Hine, Eylul Harputlugil, Yue Zhang, Christoph Ruckenstuhl, Byung Cheon Lee, Lear Brace, Alban Longchamp, Jose H. Treviño-Villarreal, Pedro Mejia, C. Keith Ozaki, Rui Wang, Vadim N. Gladyshev, Frank Madeo, William B. Mair, James R. Mitchell. Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction BenefitsCell, 2014; DOI: 10.1016/j.cell.2014.11.048

Appendix BB

Tuesday, July 16, 2013
Rabies , Alzheimers and Formic acid
Rabies , Alzheimers and Formic acid

Andre Willers
17 Jul 2013
Synopsis :
Formic acid opens the Blood Brain Barrier(BBB) . This enables the immune system to interact with brain cells . Only to be used in very controlled circumstances .

Discussion :
1.The Blood Brain Barrier evolved from skin .  See Appendix A.
2.Formic acid bypasses skin . See Appendix B

3.In extremis :
If somebody is dying in convulsions from rabies , an infusion of formic acid might help .
Under more controlled conditions , it might help for some forms of brain cancers and plaques . (Eg alzheimers)
The immune system is quite capable of seeing these pests off , but is prevented by the Blood Brain Barrier .

4.Creating a portal in the BloodBrainBarrier .
4.1 A pulse of formic acid to open the barrier .
4.2 A pulse of botox to freeze it open .
4.3 Can be done in one capsule with hydrophilic and hydrophobic ends .

5.The cost :
Memories . The BBB evolved as a safeguard for the identity-complex . The immune system will scrub this .
The person won’t die physically , but the personality won’t survive .

6.Pain , etc
Long nerve damage (eg peripheral neuropathy) .
Micro-injections of formic acid is analogous to botox . It enables the body’s repair mechanisms .
Should help with auto-immune diseases like arthritis .
Maybe even degenerative diseases like Alzheimers .

7. Or  ants .

8.A bit of Formic acid with the Botox will make it permanent . But also reduce brain degeneration .
Beauty and Brains in Old age.
This would be a disaster if not for the rapid mutation rate in mental processes and memory caused by formic acid .

Live forever , but better keep a diary .

Appendix A
During lethal rabies infection of mice, the blood–brain barrier (BBB) does not allow anti-viral immune cells to enter the brain, the primary site of rabies virus replication. This aspect contributes to the pathogenicity of the virus and artificially increasing BBB permeability promotes viral clearance. Opening the BBB during rabies infection has been suggested as a possible novel approach to treating the disease, even though no attempts have yet been made to determine whether or not this treatment could be successful.[original r
This post was published to Andre's Why at 05:05:06 PM 2013/01/12
Appendix B
Training the Immune System
Andre Willers
12 Jan 2012
Commercially available desensitization technologies are now available for Milk , Peanut and DustMite allergies .

Discussion :
1.This involves skin-patches  , exposing the organism to prolonged exposure to the allergy-producing chemicals , but at such low levels that anaphylactic shock is not induced .
2.But , the learning systems of the Immune system are engaged (Dentritic cells)
See Appendix I
3.At least , some clinical testing of the three products available (milk , peanuts , dustmite asthma) is being done .
See .
4.This is but a high-tech approach to the old-age approach to test for poisons . Put a sample of the material to be tested on the skin . Watch what happens .
 Used from Neolithic times . And present day doctors for allergies .
5.The Trick :
The skin usually prevents deleterious amounts of the allergy –producing chemical from passing through .
6.Plant-Herbivore Wars :
Some plants have developed ways of bypassing this barrier . Contact poisons . Like itching thistles , stinging nettles , etc.
Do not use the patches if you might be exposed to stinging nettles or their ilk .
7.Opportunity : Instant safe reprogramming .
These poisons can be used to deliver nano-levels of active allergens directly to the dendritic cells . Shortening the training period to fractions of a second .
8.This opens a whole new can of worms .
Near-instantaneous reprogramming of the immune system will have obvious shock effects . But this can be quite useful in things like melanoma’s .
See Appendix II .
Since only nanograms of the allergen is required , addition of the nettle-bypass chemicals will flood the dentritic cells with maybe too much information . (It is not a smart system).
But in the case of overproduction of particular allergens , these will train the immune system . Like cancers .
Note that the gut-system is but internal skin .
9.The buccal interface :
This will take place mostly in the mouth .
Very little survives the stomach acid-bath .
So swirl the nettle-soup in the mouth .
See Appendix III A
Your mother was right . Don’t gulp it down .

10 . Nettle-active capsules
Nettle-active Capsules that only dissolve past the stomach will need some thorough testing .
Buccal systems have some strong safeguards (they handle garlic  (Allicin) , after all . One of the most proficient cell-killers) 
But something like this would of great use in Crohn’s Disease and other intestinal auto-immune diseases .
For the active chemicals , see Appendix V A

11.Auto-immune Diseases :
These are obvious candidates . Especially that nasty Arthritis . A nettle-system patch combined with an alternate target like dust-mites (available) can make short work of arthritis .

12.Diabetes II
See Appendix III for a cure
You will also need Phene Systems : see Appendix IV
The exact molecular mechanism of Insulin docking to the Cell-wall has recently been worked out . It is an active system .
Portions of the Insulin molecule folds out to match portions of the cell-wall that also outfolds to latch together .
Which is why you need phene-systems .
The trigger seems to be formic acid .
See Appendix V A .
Formic acid is used extensively by insects and plants to bypass phene barriers . A simple molecule (as expected . It is very old-about 3 billion years)
It is an azeotrope (See
From Wikipedia, the free encyclopedia

Vapor-liquid equilibrium of 2-propanol/water showing azeotropic behavior
An azeotrope (pron.: /əˈziːətroʊp/ ə-zee-ə-trohp or pron.: /ˈeɪziətroʊp/ ay-zee-ə-trohp) is a mixture of two or more liquids in such a way that its components cannot be altered by simple distillation.[1] This happens because, when an azeotrope is boiled, the vapor it produces has proportionate constituents as the original mixture.
These chemicals are favoured by evolution because they are invariant to phase change . They keep on working at any state.
Used extensively in hibernation systems to bypass cellular barriers . See Appendix VI A .

The molecule seems to have only five nexi , yet it seems able to collapse quantum – wavefronts ( see )
Can it be simpler ? I don’t know . Four nexi will have to be designed , but I might be wrong .

Formic acid seems to be a sine-qua-non for multicellular organisms .
Quite surprising .

13, To get back to Diabetes II
We use the Buccal Transform :
Make a solution of Formic Acid < 2% , with a dash of serotonin and histamine . Add the active thingie you want the immune system to learn about .
13.1 Diabetes II
Add about 1 teaspoon of sugar/20 ml of lukewarm water . Stir and rinse the mouth extensively . See Appendix II A .Spit it out .
The spitting out is vital . The pulse of sugars must not reach the descending duodenal .
What is happening ?
The preparation system is notifying the descending duodenal system (see Appendix III A ) . A lot of sugar is coming . Then it does not arrive .
This is a pretty stupid system . After 3+1 iterations it stops believing the incoming signals and stands down .
Ordinary phene systems apply . A quick cure .
13.2 Other intestinal problems can be handled in an analogous fashion .

14.Outer-Skin problems .
Use Formic acid , serotonin and histamine patches(in correct proportion) plus target chemical .
Simple . Quick , too , with the Formic Acid .

14. Who would have thought ?
Ants are caught in a terrible cellular trap . They are forced into a communal mind by formic acid .

An interesting aside :
Bioengineering ants not to excrete formic will have interesting results . I would recommend Biolevel 5 Controls

15. Oxytocin and Formic Acid
Oxytocin is an expanded version of formic acid . Compare the molecular structures
See and
Oxytocin has only one ring , so is topologically equivalent to dopamine .

16 .Does any molecule not collapse quantum-wavefronts ? It only seems like it . We are looking at a very specific sub-group .

Who would have thought that eating ants kick-started human evolution ?

“Feeling antsy is the beginning of wisdom “ Buddha-Ant


Appendix I

About VIASKIN® Technology 

When the VIASKIN® patch containing a specific allergen is applied to the skin of a patient with an IgE-mediated allergy - such as peanuts or milk - the allergens are deposited locally on the skin and are captured specifically by the skin's immuno-competent cells. This triggers the modulations of the immune responses. The epicutaneous exposure is non-invasive: the skin naturally prevents the allergen from entering the bloodstream and thereby dramatically reduces the risk of inducing anaphylaxis. The VIASKIN® patch is designed to be easily and painlessly applied by healthcare professionals and also by the patient or his/her parents at home, which facilitates compliance with the treatment. 
Appendix II
Nettle soup
Nettle soup is a traditional soup prepared from stinging nettles. Nettle soup is eaten mainly during spring and early summer, when young nettle buds are collected. Today, nettle soup is mostly eaten in Scandinavia and Eastern Europe, but historically consumption of nettles was more widespread. Nettle stew was eaten by inhabitants of Britain in the bronze age, 3000 years ago.[1]


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